Journal of Polymer Science,
Год журнала:
2024,
Номер
62(22), С. 4966 - 4992
Опубликована: Авг. 9, 2024
Abstract
In
recent
years,
the
prevalence
of
bone
diseases
is
showing
an
increasing
trend,
which
mainly
attributed
to
aging
global
population.
However,
repair
and
regeneration
are
still
unsolved
problem
in
treatment
diseases,
include
a
series
biological
events.
Photocrosslinked
natural
hydrogel‐based
microspheres
(PNHMs)
spherical
particles
composed
photocrosslinked
hydrogel
components.
Due
their
morphology,
injectability,
biocompatibility,
PNHMs
widely
used
tissue
regeneration,
particularly
for
defects.
this
article,
we
review
available
materials
PNHMs,
then
introduce
preparation
methods.
After
that,
summarize
important
advanced
functionalities
PNHMs.
For
example,
can
be
loaded
with
different
active
ingredients
exert
anti‐inflammatory,
antibacterial,
antioxidant
effects,
while
also
realizing
lubrication
due
specific
shape
size
distribution.
addition,
function
capturing
ions
realized
via
coordination.
When
applied
engineering,
promote
angiogenesis
osteogenesis,
great
potential
diseases.
Finally,
challenges
prospects
discussed.
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 95 - 108
Опубликована: Апрель 23, 2024
Androgenetic
alopecia
(AGA),
the
most
prevalent
clinical
hair
loss,
lacks
safe
and
effective
treatments
due
to
downregulated
angiogenic
genes
insufficient
vascularization
in
perifollicular
microenvironment
of
bald
scalp
AGA
patients.
In
this
study,
a
hyaluronic
acid
(HA)
based
hydrogel-formed
microneedle
(MN)
was
designed,
referred
as
V-R-MNs,
which
simultaneously
loaded
with
vascular
endothelial
growth
factor
(VEGF)
novel
loss
drug
Ritlecitinib,
latter
is
encapsulated
slowly
biodegradable
polyhydroxyalkanoates
(PHAs)
nanoparticles
(R-PHA
NPs)
for
minimally
invasive
treatment.
The
integration
HA
hydrogel
alongside
PHA
significantly
bolstered
mechanical
characteristics
microneedles
enhanced
skin
penetration
efficiency.
Due
biosafety,
strength,
controlled
degradation
properties
formed
microneedles,
V-R-MNs
can
effectively
penetrate
skin's
stratum
corneum,
facilitating
direct
delivery
VEGF
Ritlecitinib
invasive,
painless
long-term
sustained
release
manner.
not
only
promoted
angiogenesis
improve
immune
around
follicle
promote
proliferation
development
cells,
but
also
application
MNs
produce
certain
stimulation
could
angiogenesis.
comparison
minoxidil
treatment,
regeneration
effect
V-R-MN
model
mice
characterized
by
rapid
onset
anagen
phase,
improved
quality,
greater
coverage.
This
introduces
new,
clinically
safer,
more
efficient
strategy
serving
reference
treatment
other
related
diseases.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Май 16, 2024
The
regeneration
of
critical-size
bone
defects,
especially
those
with
irregular
shapes,
remains
a
clinical
challenge.
Various
biomaterials
have
been
developed
to
enhance
regeneration,
but
the
limitations
on
shape-adaptive
capacity,
complexity
operation,
and
unsatisfied
osteogenic
bioactivity
greatly
restricted
their
application.
In
this
work,
we
construct
mechanically
robust,
tailorable
water-responsive
shape-memory
silk
fibroin/magnesium
(SF/MgO)
composite
scaffold,
which
is
able
quickly
match
defects
by
simple
trimming,
thus
leading
good
interface
integration.
We
demonstrate
that
SF/MgO
scaffold
exhibits
excellent
mechanical
stability
structure
retention
during
degradative
process
potential
for
supporting
ability
in
defective
areas.
This
further
promotes
proliferation,
adhesion
migration
osteoblasts
differentiation
marrow
mesenchymal
stem
cells
(BMSCs)
vitro.
With
suitable
MgO
content,
histocompatibility,
low
foreign-body
reactions
(FBRs),
significant
ectopic
mineralisation
angiogenesis.
Skull
defect
experiments
male
rats
cell-free
markedly
enhances
cranial
defects.
Taken
together,
personalised
bioactive
may
be
promising
biomaterial
clinical-size
regeneration.
Abstract
Infected
bone
defects
are
one
of
the
most
challenging
problems
in
treatment
due
to
high
antibiotic
failure
rate
and
lack
ideal
grafts.
In
this
paper,
inspired
by
clinical
cement
filling
treatment,
α
‐c
phosphate
(
‐TCP)
with
self‐curing
properties
is
composited
β
‐tricalcium
constructed
a
bionic
cancellous
scaffolding
system
α/β‐tricalcium
/
low‐temperature
3D
printing,
gelatin
preserved
inside
scaffolds
as
an
organic
phase,
later
loaded
metal–polyphenol
network
structure
tea
polyphenol‐magnesium
(TP‐Mg)
nanoparticles.
The
mimic
components
mechanical
strength
(>100
MPa)
based
on
‐TCP
through
printing.
Meanwhile,
TP‐Mg
exhibit
significant
inhibition
Staphylococcus
aureus
S.aureus
)
promote
transition
macrophages
from
M1
pro‐inflammatory
M2
anti‐inflammatory
phenotype.
addition,
composite
scaffold
also
exhibits
excellent
bone‐enhancing
effects
synergistic
effect
Mg
2+
Ca
.
study,
multifunctional
ceramic
‐TCP@TP‐Mg)
that
integrates
anti‐inflammatory,
antibacterial,
osteoinduction
constructed,
which
promotes
late
regenerative
healing
while
modulating
early
microenvironment
infected
defects,
has
promising
application
defects.
Gels,
Год журнала:
2024,
Номер
10(8), С. 513 - 513
Опубликована: Авг. 3, 2024
Nanoclay-composite
hydrogels
represent
a
promising
avenue
for
advancing
bone
tissue
engineering.
Traditional
face
challenges
in
providing
mechanical
strength,
biocompatibility,
and
bioactivity
necessary
successful
regeneration.
The
incorporation
of
nanoclay
into
hydrogel
matrices
offers
potential
unique
solution
to
these
challenges.
This
review
provides
comprehensive
overview
the
fabrication,
physico-chemical/biological
performance,
applications
nanoclay-composite
Various
fabrication
techniques,
including
situ
polymerization,
physical
blending,
3D
printing,
are
discussed.
In
vitro
vivo
studies
evaluating
biocompatibility
have
demonstrated
promoting
cell
adhesion,
proliferation,
differentiation.
Their
defect
repair,
osteochondral
engineering
drug
delivery
also
explored.
Despite
their
engineering,
such
as
optimal
dispersion,
scalability,
long-term
stability,
regulatory
approval,
integration
with
emerging
technologies
achieve
clinical
application.
Future
research
directions
need
focus
on
refining
enhancing
understanding
biological
interactions,
towards
translation
commercialization.
Overall,
offer
exciting
opportunities
improving
regeneration
strategies.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Abstract
Hydrogel
scaffolds
perform
well
for
periodontal
bone
regeneration.
However,
due
to
lacking
injectability,
poor
mechanical
strength,
and
weak
adhesive
force,
conventional
hydrogels
are
difficult
adapt
irregular
defects
unable
maintain
stability
under
occlusal
force.
Consequently,
the
current
approaches
still
present
significant
challenges
in
achieving
intact
3D
Herein,
a
calcium‐capturing
self‐reinforcing
hydrogel,
composed
of
alendronate‐functionalized
oxidized
sodium
alginate
(OSA‐Alen),
nano‐hydroxyapatite
(HAP),
dopamine‐grafted
gelatin
(Gel‐DA),
is
prepared
The
Schiff‐base
reaction
endows
hydrogel
with
while
dynamic
coordination
between
OSA‐Alen
HAP
confers
superior
self‐healing
ability
homogeneous
distribution
HAP.
Tissue
adhesiveness
from
Gel‐DA
enables
within
defect
area.
Furthermore,
self‐reinforces
mechanically
by
calcium
ion
(Ca
2+
)
capturing,
providing
supportive
matrix
regeneration,
promoting
osteogenesis
Ca
influx.
Especially,
via
rat
model,
vivo
examination
displays
regeneration
directions
(57.03%
volume
fraction
achieved)
after
being
treated
injectable
eight
weeks.
offers
an
alternative
biomaterial
presents
profound
potential
repair
peri‐implant
loss
near
future.
Biomaterials Science,
Год журнала:
2023,
Номер
11(18), С. 6013 - 6034
Опубликована: Янв. 1, 2023
Polyhydroxyalkanoates
(PHAs),
a
family
of
natural
microbial
biopolyesters
via
with
excellent
biodegradability
and
biosafety,
can
be
produced
optimally
synthetic
biology
designed
to
various
medical
devices
for
applications.
