Advances in photocrosslinked natural hydrogel‐based microspheres for bone repair DOI Open Access

Hao‐Ru Li,

Jing Zhou, Yanwen Zhou

et al.

Journal of Polymer Science, Journal Year: 2024, Volume and Issue: 62(22), P. 4966 - 4992

Published: Aug. 9, 2024

Abstract In recent years, the prevalence of bone diseases is showing an increasing trend, which mainly attributed to aging global population. However, repair and regeneration are still unsolved problem in treatment diseases, include a series biological events. Photocrosslinked natural hydrogel‐based microspheres (PNHMs) spherical particles composed photocrosslinked hydrogel components. Due their morphology, injectability, biocompatibility, PNHMs widely used tissue regeneration, particularly for defects. this article, we review available materials PNHMs, then introduce preparation methods. After that, summarize important advanced functionalities PNHMs. For example, can be loaded with different active ingredients exert anti‐inflammatory, antibacterial, antioxidant effects, while also realizing lubrication due specific shape size distribution. addition, function capturing ions realized via coordination. When applied engineering, promote angiogenesis osteogenesis, great potential diseases. Finally, challenges prospects discussed.

Language: Английский

Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment DOI Creative Commons
Yanwen Ding, Yang Li, Zhiwei Zhang

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 95 - 108

Published: April 23, 2024

Androgenetic alopecia (AGA), the most prevalent clinical hair loss, lacks safe and effective treatments due to downregulated angiogenic genes insufficient vascularization in perifollicular microenvironment of bald scalp AGA patients. In this study, a hyaluronic acid (HA) based hydrogel-formed microneedle (MN) was designed, referred as V-R-MNs, which simultaneously loaded with vascular endothelial growth factor (VEGF) novel loss drug Ritlecitinib, latter is encapsulated slowly biodegradable polyhydroxyalkanoates (PHAs) nanoparticles (R-PHA NPs) for minimally invasive treatment. The integration HA hydrogel alongside PHA significantly bolstered mechanical characteristics microneedles enhanced skin penetration efficiency. Due biosafety, strength, controlled degradation properties formed microneedles, V-R-MNs can effectively penetrate skin's stratum corneum, facilitating direct delivery VEGF Ritlecitinib invasive, painless long-term sustained release manner. not only promoted angiogenesis improve immune around follicle promote proliferation development cells, but also application MNs produce certain stimulation could angiogenesis. comparison minoxidil treatment, regeneration effect V-R-MN model mice characterized by rapid onset anagen phase, improved quality, greater coverage. This introduces new, clinically safer, more efficient strategy serving reference treatment other related diseases.

Language: Английский

Citations

32
Mechanically robust and personalized silk fibroin-magnesium composite scaffolds with water-responsive shape-memory for irregular bone regeneration DOI Creative Commons

Zhinan Mao,

Xuewei Bi,

Chunhao Yu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 16, 2024

The regeneration of critical-size bone defects, especially those with irregular shapes, remains a clinical challenge. Various biomaterials have been developed to enhance regeneration, but the limitations on shape-adaptive capacity, complexity operation, and unsatisfied osteogenic bioactivity greatly restricted their application. In this work, we construct mechanically robust, tailorable water-responsive shape-memory silk fibroin/magnesium (SF/MgO) composite scaffold, which is able quickly match defects by simple trimming, thus leading good interface integration. We demonstrate that SF/MgO scaffold exhibits excellent mechanical stability structure retention during degradative process potential for supporting ability in defective areas. This further promotes proliferation, adhesion migration osteoblasts differentiation marrow mesenchymal stem cells (BMSCs) vitro. With suitable MgO content, histocompatibility, low foreign-body reactions (FBRs), significant ectopic mineralisation angiogenesis. Skull defect experiments male rats cell-free markedly enhances cranial defects. Taken together, personalised bioactive may be promising biomaterial clinical-size regeneration.

Language: Английский

Citations

24
3D Printed Multifunctional Biomimetic Bone Scaffold Combined with TP‐Mg Nanoparticles for the Infectious Bone Defects Repair DOI Creative Commons
Xulin Hu, Jiao Chen,

Shuhao Yang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 28, 2024

Abstract Infected bone defects are one of the most challenging problems in treatment due to high antibiotic failure rate and lack ideal grafts. In this paper, inspired by clinical cement filling treatment, α ‐c phosphate ( ‐TCP) with self‐curing properties is composited β ‐tricalcium constructed a bionic cancellous scaffolding system α/β‐tricalcium / low‐temperature 3D printing, gelatin preserved inside scaffolds as an organic phase, later loaded metal–polyphenol network structure tea polyphenol‐magnesium (TP‐Mg) nanoparticles. The mimic components mechanical strength (>100 MPa) based on ‐TCP through printing. Meanwhile, TP‐Mg exhibit significant inhibition Staphylococcus aureus S.aureus ) promote transition macrophages from M1 pro‐inflammatory M2 anti‐inflammatory phenotype. addition, composite scaffold also exhibits excellent bone‐enhancing effects synergistic effect Mg 2+ Ca . study, multifunctional ceramic ‐TCP@TP‐Mg) that integrates anti‐inflammatory, antibacterial, osteoinduction constructed, which promotes late regenerative healing while modulating early microenvironment infected defects, has promising application defects.

Language: Английский

Citations

19
Carbon Cycle of Polyhydroxyalkanoates (CCP): Biosynthesis and Biodegradation DOI
Siqin Zhang, Huishu Yuan, Xue Ma

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120904 - 120904

Published: Jan. 1, 2025

Language: Английский

Citations

2
Bioactive hydrogel formulations for regeneration of pathological bone defects DOI
Zuhao Li, Kaixuan Ren, Jiajia Chen

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 686 - 714

Published: Feb. 17, 2025

Language: Английский

Citations

2
Regulation of TiO2 @PVDF piezoelectric nanofiber membranes on osteogenic differentiation of mesenchymal stem cells DOI
Jing Liu,

Yaya Cheng,

Haoyu Wang

et al.

Nano Energy, Journal Year: 2023, Volume and Issue: 115, P. 108742 - 108742

Published: July 29, 2023

Language: Английский

Citations

38
Nanoclay-Composite Hydrogels for Bone Tissue Engineering DOI Creative Commons

Hee Sook Hwang,

Chung‐Sung Lee

Gels, Journal Year: 2024, Volume and Issue: 10(8), P. 513 - 513

Published: Aug. 3, 2024

Nanoclay-composite hydrogels represent a promising avenue for advancing bone tissue engineering. Traditional face challenges in providing mechanical strength, biocompatibility, and bioactivity necessary successful regeneration. The incorporation of nanoclay into hydrogel matrices offers potential unique solution to these challenges. This review provides comprehensive overview the fabrication, physico-chemical/biological performance, applications nanoclay-composite Various fabrication techniques, including situ polymerization, physical blending, 3D printing, are discussed. In vitro vivo studies evaluating biocompatibility have demonstrated promoting cell adhesion, proliferation, differentiation. Their defect repair, osteochondral engineering drug delivery also explored. Despite their engineering, such as optimal dispersion, scalability, long-term stability, regulatory approval, integration with emerging technologies achieve clinical application. Future research directions need focus on refining enhancing understanding biological interactions, towards translation commercialization. Overall, offer exciting opportunities improving regeneration strategies.

Language: Английский

Citations

10
A comprehensive review of conventional and stimuli-responsive delivery systems for bioactive peptides: from food to biomedical applications DOI
Shuang Wang, Xinhao Wang, Yangchao Luo

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 8(1)

Published: Nov. 30, 2024

Language: Английский

Citations

10
Calcium‐Capturing Hydrogel with Self‐Reinforced Multi‐Dynamic Networks for Effective Periodontal Bone Regeneration in Three‐Dimension DOI Open Access
Mei Zhang,

Qingchen Feng,

Guanning Zhang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Abstract Hydrogel scaffolds perform well for periodontal bone regeneration. However, due to lacking injectability, poor mechanical strength, and weak adhesive force, conventional hydrogels are difficult adapt irregular defects unable maintain stability under occlusal force. Consequently, the current approaches still present significant challenges in achieving intact 3D Herein, a calcium‐capturing self‐reinforcing hydrogel, composed of alendronate‐functionalized oxidized sodium alginate (OSA‐Alen), nano‐hydroxyapatite (HAP), dopamine‐grafted gelatin (Gel‐DA), is prepared The Schiff‐base reaction endows hydrogel with while dynamic coordination between OSA‐Alen HAP confers superior self‐healing ability homogeneous distribution HAP. Tissue adhesiveness from Gel‐DA enables within defect area. Furthermore, self‐reinforces mechanically by calcium ion (Ca 2+ ) capturing, providing supportive matrix regeneration, promoting osteogenesis Ca influx. Especially, via rat model, vivo examination displays regeneration directions (57.03% volume fraction achieved) after being treated injectable eight weeks. offers an alternative biomaterial presents profound potential repair peri‐implant loss near future.

Language: Английский

Citations

1
Polyhydroxyalkanoates: the natural biopolyester for future medical innovations DOI
Zi-Wei Ren, Zeyu Wang,

Yanwen Ding

et al.

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(18), P. 6013 - 6034

Published: Jan. 1, 2023

Polyhydroxyalkanoates (PHAs), a family of natural microbial biopolyesters via with excellent biodegradability and biosafety, can be produced optimally synthetic biology designed to various medical devices for applications.

Language: Английский

Citations

17