Pyroptosis‐Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy DOI Creative Commons
Hao Yin, Tanzhou Chen, Xiaoqu Hu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Pyroptosis can effectively overcome immunosuppression and reactivate antitumor immunity. However, pyroptosis initiation is challenging. First, the underlying biological mechanisms of are complex, a variety gasdermin family proteins be targeted to induce pyroptosis. Second, other intracellular death pathways may also interfere with The rationally designed protein‐targeting biomaterials capable inducing have capacity stimulate immune function in safe effective manner. This review provides comprehensive overview design, function, efficacy pyroptosis‐inducing materials associated challenges, particular focus on design options for based activation different proteins. offers valuable foundation further development clinical applications.

Language: Английский

Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy DOI
Qiao Yu,

Shumin Sun,

Nailin Yang

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and subsequent release DNA (mtDNA), which is anticipated to activate cGAS-STING pathway, thereby augmenting antitumor immune response. However, challenges lie in effectively triggering cancer cells subsequently enhancing activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators cobalt fluoride (CoF2) nanocatalysts for catalytic metalloimmunotherapy. CoF2 a semiconductor structure enzyme-like activity generated substantial amount reactive oxygen species (ROS) under stimulation by endogenous H2O2 exogenous ultrasound. Importantly, discovered that Co-based nanomaterials themselves induce cells. Therefore, initially acted as inducers, caspase-1/GSDMD-dependent via Co2+ ROS, leading mtDNA release. Subsequently, were further utilized STING agonists specifically capable detecting pathway. These cascade events triggered robust response, modulating immunosuppressive tumor microenvironment into an immune-supportive state, providing favorable support therapy. This innovative strategy not only significantly impeded growth primary but also elicited response augment efficacy checkpoint inhibitors preventing distant progression. Overall, this study proposed self-cascade activating amplifying pathway specificity mediated pyroptosis, representing valuable avenue future

Language: Английский

Citations

3
Membrane-anchoring clickable Iridium(III) nanosonosensitizer in situ evokes PANoptosis for augmented tumor sono-immunotherapy DOI
Xiaoyu Xu,

Shayibai Shabiti,

Xu Zhang

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102270 - 102270

Published: April 15, 2024

Language: Английский

Citations

15
High-Z elements dominated bismuth-based heterojunction nano-semiconductor for radiotherapy-enhanced sonodynamic breast cancer therapy DOI

Lejin Zhu,

Guobo Chen, Qian Wang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 662, P. 914 - 927

Published: Feb. 9, 2024

Language: Английский

Citations

13
Hypoxia-accelerating pyroptosis nanoinducers for promoting image-guided cancer immunotherapy DOI
Dongfang Liu,

Mengyun Liang,

Yongyou Tao

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122610 - 122610

Published: May 11, 2024

Language: Английский

Citations

13
Biodegradable Vanadium-Based Nanomaterials for Photothermal-Enhanced Tumor Ferroptosis and Pyroptosis DOI

Jinzha Zhang,

Ming Shi, Jiawen Sun

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

The designability and high reactivity of nanotechnology provide strategies for antitumor therapy by regulating the redox state in tumor cells. Here, we synthesize a kind vanadium dioxide nanoparticle encapsulated bovine serum albumin containing disulfide bonds (VSB NPs) photothermal-enhanced ferroptosis pyroptosis effects. Mechanism studies show that can effectively consume overexpressed glutathione (GSH) microenvironment, leading to decrease peroxidase 4 (GPX4) activity. Simultaneously, tetravalent induce catalytic reaction H2O2, producing plenty toxic hydroxyl radicals (·OH) singlet oxygen (1O2), cell ferroptosis. In addition, consumption also lead degradation nanoparticles into high-valent vanadates, activating thermal protein domain-associated 3 (NLRP3) inflammasomes causing pyroptosis. It is worth mentioning VSB NPs not only ablate cells under near-infrared light irradiation but further disrupt homeostasis thereby enhancing induced biodegradable vanadium-based nanomaterials. This strategy, based on biological effects regulate cells, provides possibilities cancer treatment.

Language: Английский

Citations

2
Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy DOI

Qi‐Chao Yang,

Yuanyuan Wang, Shuo Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 283 - 294

Published: Jan. 25, 2025

Language: Английский

Citations

2
Programable Prodrug Nanomodulator Targets Tumor Redox Homeostasis Imbalance to Amplify Disulfidptosis and Immunogenic Pyroptosis for Breast Tumor Immunotherapy DOI Open Access
Ayeskanta Mohanty, Adityanarayan Mohapatra,

Woojin Yang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Despite the great potential of photodynamic therapy (PDT), its success remains compromised by abnormal redox homeostasis tumor cells, which supports survival, growth, and resistance to oxidative therapeutic interventions neutralizing reactive oxygen species (ROS). To overcome this barrier, a multifunctional prodrug nanomodulator (Pro@FLNC) is designed induce disulfidptosis immunogenic pyroptosis trigger an antitumor immune response. Pro@FLNC features core–shell structure where ursolic acid (UA) Chlorin e6 (Ce6) are conjugated via GSH‐responsive linker encapsulated in DSPE‐PEG‐FA lipid shell for enhanced stability, biocompatibility, tumor‐specific targeting. Within microenvironment (TME), depletes intracellular GSH, disrupts homeostasis, releases Ce6 UA, triggering stress mitochondrial dysfunction. These mechanisms amplify ROS production, promote peroxidation, initiate disulfidptosis, evidenced increased SLC7A11 expression F‐actin collapse. Elevated levels metabolic imbalance‐triggered further activate pyroptosis, releasing damage‐associated molecular patterns (DAMPs) that stimulate dendritic cell maturation cytotoxic T‐cell activation. Together, reshapes TME, reduces immunosuppressive promotes CD8 + infiltration, effectively suppressing primary tumors metastases. This programmed offers promising strategy enhance PDT immunotherapy advanced breast cancer.

Language: Английский

Citations

1
Plasma Membrane Targeted Photodynamic Nanoagonist to Potentiate Immune Checkpoint Blockade Therapy by Initiating Tumor Cell Pyroptosis and Depleting Infiltrating B Cells DOI
Yingtao Zhong,

Ziwen Qiu,

Keyan Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Abstract Immune checkpoint blockade (ICB) therapy has achieved remarkable benefits in the treatment of malignant tumors, but clinical response rates are unsatisfied due to low tumor immunogenicity and abundant immunosuppressive cells. Herein, a plasma membrane targeted photodynamic nanoagonist (designated as PMTPN) is developed potentiate ICB by initiating cell pyroptosis depleting infiltrating B PMTPN composed rationally designed chimeric peptide sequence loaded with Bruton's tyrosine kinase inhibitor (Ibrutinib). Notably, capable sequentially targeting trigger immunogenic cause overwhelming release cytokines, promoting dendritic cells maturation, cytotoxic T lymphocytes (CTLs) activation. Meanwhile, can also deplete reduce secretion interleukin‐10 decrease regulatory enhance CTLs infiltration. Beneficially, synergistic immune modulating characteristics simultaneously eliminate primary distant tumors. This study offers promising strategy elevate immunotherapeutic rate consideration complex factors.

Language: Английский

Citations

1
A thermoresponsive nanocomposite integrates NIR-II-absorbing small molecule with lonidamine for pyroptosis-promoted synergistic immunotherapy DOI Creative Commons
Pengfei Chen, Chi Zhang,

Liuliang He

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 10, 2024

Photothermal immunotherapy is regarded as the ideal cancer therapeutic modality to against malignant solid tumors; however, its benefits are often modest and require improvement. In this study, a thermoresponsive nanoparticle (BTN@LND) composed of photothermal agent (PTA) pyroptosis inducer (lonidamine) were developed enhance applications. Specifically, our "two-step" donor engineering strategy produced strong NIR-II-absorbing organic small-molecule PTA (BTN) that exhibited high NIR-II performance (ε

Language: Английский

Citations

5
A metal anion strategy to induce pyroptosis combined with STING activation to synergistically amplify anti-tumor immunity DOI
Zifan Pei, Nan Jiang, Fei Gong

et al.

Materials Today, Journal Year: 2024, Volume and Issue: 80, P. 23 - 39

Published: Aug. 16, 2024

Language: Английский

Citations

5