Biomacromolecules,
Год журнала:
2024,
Номер
25(11), С. 6967 - 6986
Опубликована: Окт. 17, 2024
Supramolecular
peptide
hydrogels
(SPHs)
consist
of
peptides
containing
hydrogelators
and
functional
epitopes,
which
can
first
self-assemble
into
nanofibers
then
physically
entangle
together
to
form
dynamic
three-dimensional
networks.
Their
porous
structures,
excellent
bioactivity,
high
dynamicity,
similar
an
extracellular
matrix
(ECM),
have
great
potential
in
artificial
ECM.
The
properties
the
hydrogel
are
largely
dependent
on
peptides.
noncovalent
interactions
among
drive
formation
assemblies
further
transition
hydrogels,
while
bioactive
epitopes
modulate
cell-cell
cell-ECM
interactions.
Therefore,
SPHs
support
cell
growth,
making
them
ideal
biomaterials
for
ECM
mimics.
This
Review
outlines
classical
molecular
design
from
summarizes
recent
advancements
as
ECMs
nervous
system
repair,
wound
healing,
bone
cartilage
regeneration,
organoid
culture.
emerging
SPH
platform
could
provide
alternative
strategy
developing
more
effective
tissue
engineering.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Abstract
Hyperglycemia
exacerbates
bacterial
infections,
disrupts
angiogenesis,
and
perpetuates
chronic
inflammation
in
the
wound.
Therefore,
effective
management
of
diabetic
wounds
necessitates
a
synergistic
approach
that
integrates
local
wound
microenvironment
remodeling
with
systemic
hyperglycemia
regulation.
Herein,
an
unprecedented
hierarchical
cobalt
pyrophosphate/DNA
(Co
2
PPi/DNA)
nanocomposite
is
reported
for
this
purpose.
Unlike
stereotypical
assembly
either
enzymatically
polymerized
ultralong
nucleic
acids
Mg
PPi
nanosheets
at
low
ratios
or
commercial
homo‐oligonucleotides
devoid
biofunctionalities
presence
metal
ions,
study
represents
first
demonstration
on
coordination‐driven
high‐efficiency
co‐assembly
biofunctional
hetero‐oligonucleotides
non‐Mg
nanosheets,
specifically
glucagon
receptor
(GCGR)
aptamer
Co
nanosheets.
To
improve
bioavailability
nanocomposites,
dissolvable
microneedle
patch
applied
their
delivery.
Thereafter,
nanocomposites
dissociate
sustained
release
2+
ions
GCGR
aptamer,
from
which
eliminate
colonized
bacteria
promote
angiogenesis
through
stabilizing
HIF‐1α,
meanwhile,
after
circulating
to
liver
reduces
blood
glucose
levels
by
binding
hepatocyte
GCGR.
Importantly,
hypoglycemic
effect
promotes
antibacterial
pro‐angiogenic
efficacy
alleviates
inflammatory
responses.
This
work
highlights
significant
advancements
coordination
into
versatile
architecture
remodel
pathological
facilitated
factor
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Diabetic
wounds
are
refractory
and
recurrent
diseases
that
necessitate
the
development
of
multifunctional
dressings.
Inspired
by
structure
function
skin,
we
herein
delicately
design
a
novel
swollen
hydrophobic
hydrogel
(QL@MAB)
composed
methyl
acrylate
(MA)
(3-acrylamidophenyl)boronic
acid
(AAPBA)
network
co-loaded
with
antioxidant
quercetin
(Q)
antibiotic
levofloxacin
(L)
for
efficient
diabetic
wound
therapy.
The
MA
segments
undergo
phase
separation
to
form
dense
"epidermis",
ensuring
prolonged
drug
diffusion,
long-term
water
retention,
high
content.
Meanwhile,
AAPBA
generate
glucose-labile
"sweat
pores"
via
borate
ester
bonds
polyphenol
Q.
Upon
encountering
hyperglycemic
microenvironment,
dilated
due
cleavage
exposure
diffusion
channel,
facilitating
release
accelerated
healing.
In
infected
rats,
QL@MAB
achieves
rapid
debridement
re-epithelization
while
promoting
angiogenesis,
hair
follicle
regeneration,
extracellular
matrix
remodeling.
Taken
together,
this
study
not
only
represents
multipronged
dressing
effective
interventions
but
also
contributes
rational
smart
hydrogels
tailored
biomedical
applications.
Bioactive Materials,
Год журнала:
2024,
Номер
41, С. 193 - 206
Опубликована: Июль 20, 2024
Regulating
macrophage
phenotypes
to
reconcile
the
conflict
between
bacterial
suppression
and
tissue
regeneration
is
ideal
for
treating
infectious
skin
wounds.
Here,
an
injectable
immunoregulatory
hydrogel
(SrmE20)
that
sequentially
drives
phenotypic
polarization
(M0
M1,
then
M2)
was
constructed
by
integrating
anti-inflammatory
components
proinflammatory
solvents.
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Ноя. 9, 2024
Since
wound
healing
is
one
of
the
most
important
medical
challenges
and
common
dressings
have
not
been
able
to
manage
this
challenge
well
today,
efforts
increased
achieve
an
advanced
dressing.
Mesenchymal
stem
cells
exosomes
derived
from
them
shown
high
potential
in
regenerating
wounds
due
their
immunomodulatory,
anti-inflammatory,
immunosuppressive,
regenerative
capacities.
However,
such
as
short
life
these
cells,
low
durability
area,
stability
resulted
limitations
use
for
healing.
Nowadays,
different
scaffolds
are
considered
suitable
biomaterials
These
made
natural
or
synthetic
polymers
promising
ideal
dressing
that
does
disadvantages
dressings.
One
strategies
has
attracted
much
attention
today
using
seeding
delivering
MSCs
exosomes.
This
combined
strategy
a
enhancing
shelf
increasing
In
review,
combination
with
comprehensively
discussed.
Biomaterials Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
provides
a
comprehensive
overview
of
vascularized
cell
spheroids,
highlighting
recent
advancements
in
biofabrication,
key
strategies
for
engineering
vascular
networks,
and
their
applications
tissue
models
regenerative
medicine.
Pharmaceutics,
Год журнала:
2024,
Номер
16(8), С. 990 - 990
Опубликована: Июль 26, 2024
Wound
healing
progresses
through
three
distinct
stages:
inflammation,
proliferation,
and
remodeling.
Immune
regulation
is
a
central
component
throughout,
crucial
for
orchestrating
inflammatory
responses,
facilitating
tissue
repair,
restraining
scar
formation.
Elements
such
as
mitochondria,
reactive
oxygen
species
(ROS),
macrophages,
autophagy,
ferroptosis,
cytokines
collaboratively
shape
immune
in
this
process.
Skin
wound
dressings,
recognized
their
ability
to
augment
biomaterials’
immunomodulatory
characteristics
via
antimicrobial,
antioxidative,
pro-
or
anti-inflammatory,
tissue-regenerative
capacities,
have
garnered
heightened
attention.
Notwithstanding,
lack
of
comprehensive
research
addressing
how
these
dressings
attain
properties
the
mechanisms
thereof
persists.
Hence,
paper
pioneers
systematic
review
biomaterials,
emphasizing
underlying
immunological
mechanisms.
It
begins
by
highlighting
importance
peculiarities
obstacles
faced
skin
injury
recovery.
This
segment
explores
impact
metabolism,
infections,
systemic
illnesses,
local
immobilization
on
response
during
healing.
Subsequently,
examines
spectrum
biomaterials
utilized
therapy,
including
hydrogels,
aerogels,
electrospun
nanofiber
membranes,
collagen
scaffolds,
microneedles,
sponges,
3D-printed
constructs.
elaborates
approaches
employed
materials,
focusing
mitochondrial
ROS
modulation,
autophagic
processes,
macrophage
influence
Acknowledging
challenge
antibiotic
resistance,
also
summarizes
promising
plant-based
alternatives
biomaterial
integration,
curcumin.
In
its
concluding
sections,
charts
recent
advancements
prospects
that
accelerate
modulation.
includes
exploring
transplantation
morphology
optimization,
metal
ion
incorporation,
electrostimulation-enabled
control,
benefits
composite
materials
immune-regulatory
dressings.
The
ultimate
objective
establish
theoretical
foundation
guide
future
investigations
realm
related
science
disciplines.
