Materials Today Chemistry, Год журнала: 2024, Номер 43, С. 102467 - 102467
Опубликована: Дек. 13, 2024
Язык: Английский
Journal of Materials Chemistry B, Год журнала: 2025, Номер 13(10), С. 3420 - 3436
Опубликована: Янв. 1, 2025
A piezoelectric nanozyme is a novel biomaterial with the integration of piezoelectricity and activity that has capability killing bacteria promoting cell responses under mechanical stimulus exhibits great prospects in tissue regeneration. Herein, bismuth sulfide (BS) cationic vacancies (VBS) was synthesized, which enhanced activities compared BS. Moreover, hydrogel VBS phenylboronic acid grafted sodium alginate-arginine (VBS-PSA) prepared. Triggered by ultrasound (US) high power (>0.5 W cm-2), VBS-PSA produces large amount reactive oxygen species (ROS) through both piezoelectricity-enhanced sonodynamic efficiency peroxidase-like (POD-like) activity, thereby displaying powerful antibacterial capability. However, low-power US (≤0.5 effect generates electrical signals significantly stimulate osteoblast (proliferation differentiation) enhance catalase-like (CAT-like) for scavengers ROS generation oxygen, creating favorable microenvironment growth. Our study presents strategy to apply hydrogels enhancing synergistically kill responses. The would have potential repair infected bone defects.
Язык: Английский
Процитировано
1
Communications Chemistry, Год журнала: 2024, Номер 7(1)
Опубликована: Июнь 8, 2024
Abstract Nanoparticle-based therapies are emerging as a pivotal frontier in biomedical research, showing their potential combating infections and facilitating wound recovery. Herein, selenium-tellurium dopped copper oxide nanoparticles (SeTe-CuO NPs) with dual photodynamic photothermal properties were synthesized, presenting an efficient strategy for bacterial infections. In vitro evaluations revealed robust antibacterial activity of SeTe-CuO NPs, achieving up to 99% eradication bacteria significant biofilm inhibition upon near-infrared (NIR) irradiation. Moreover, vivo studies demonstrated accelerated closure treatment NIR-activated demonstrating efficacy promoting healing. Furthermore, NPs exhibited rapid clearance within wounds, offering promising solution care. Overall, this versatile platform holds great promise multidrug-resistant advancing therapeutic interventions management.
Язык: Английский
Процитировано
4
Chemical & Biomedical Imaging, Год журнала: 2025, Номер unknown
Опубликована: Март 4, 2025
Aggregation-induced emission luminogens (AIEgens) have been prosperously developed and applied in the fields of optical imaging theranostics since its establishment. Nowadays, AIEgens can fulfill nearly all requirements with spectra ranging from visible to near-infrared wavelengths. Although a variety varying wavelengths functionalities continuously designed, their performance is heavily dependent on use conventional light sources, such as xenon lamps lasers, which severely hinder further applications due limited penetration depth background autofluorescence biological tissues. To mitigate these limitations maximize potential AIEgens, unconventional excitation sources chemical energy, ultrasound, X-ray offer effective alternatives that circumvent drawbacks associated traditional light-based constant excitation. In this Review, we introduce fundamental principles governing combination highlight recent advancements using excited by for bioimaging theranostics, discuss current challenges future perspectives aimed at advancing biomedical AIEgens.
Язык: Английский
Процитировано
0
Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown
Опубликована: Сен. 18, 2024
Ventricular arrhythmias (VAs) triggered by myocardial infarction (MI) are the leading cause of sudden cardiac mortality worldwide. Current therapeutic strategies for managing MI-induced VAs, such as left stellate ganglion resection and ablation, suboptimal, highlighting need to explore safer more effective intervention strategies. Herein, we rationally designed two supramolecular sonosensitizers RuA RuB, engineered through acceptor modification generate moderate reactive oxygen species (ROS) modulate VAs. Both RuB demonstrated high ultrasound (US)-activated ROS production efficiency, with singlet (
Язык: Английский
Процитировано
3
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Дек. 16, 2024
Abstract Immune checkpoint inhibitors have demonstrated remarkable efficacy across various cancer types. However, immune‐related adverse events (irAEs) pose a significant challenge in immunotherapy, particularly the associated pneumonia as primary reaction, which can lead to irreversible pulmonary fibrosis. Additionally, monotherapy with programmed death ligand (PD‐L1) has shown limited effectiveness. Therefore, improve response rate of immunotherapy and reduce fibrosis, this study designed prepared an intelligent nanodrug based on dendritic mesoporous silica nanoparticles (DMSNs) loaded sono‐sensitive agent protoporphyrin IX (PpIX). reactive oxygen species (ROS) sensitive linker is used attach immunotherapeutic drug PD‐L1 inhibitor (aPD‐L1) DMSNs via covalent bonds. The external ultrasound (US) activates PpIX generate ROS, breaks release aPD‐L1 induce sonodynamic therapy (SDT) immunotherapy. This sono‐immnotherapy approach excellent outcomes tumor inhibition, eliciting immune responses, reducing Overall, offers new, efficient, safe method for breast treatment, expands application
Язык: Английский
Процитировано
3
Nano Letters, Год журнала: 2024, Номер 24(47), С. 14983 - 14992
Опубликована: Ноя. 14, 2024
(
Процитировано
1
Angewandte Chemie, Год журнала: 2024, Номер unknown
Опубликована: Сен. 18, 2024
Abstract Ventricular arrhythmias (VAs) triggered by myocardial infarction (MI) are the leading cause of sudden cardiac mortality worldwide. Current therapeutic strategies for managing MI‐induced VAs, such as left stellate ganglion resection and ablation, suboptimal, highlighting need to explore safer more effective intervention strategies. Herein, we rationally designed two supramolecular sonosensitizers RuA RuB , engineered through acceptor modification generate moderate reactive oxygen species (ROS) modulate VAs. Both demonstrated high ultrasound (US)‐activated ROS production efficiency, with singlet ( 1 O 2 ) quantum yield (Φ Δ 0.70 0.88, respectively, surpassing ligand IR1105 conventional sonosensitizer ICG =0.40). In vitro, at a modest concentration under US intensity notably boosts pro‐survival autophagy in microglia BV2 cell. To improve vivo stability biocompatibility, was further encapsulated into DSPE‐PEG 5000 prepare nanoparticles NPs). studies after microinjection NPs paraventricular nucleus (PVN) subsequent exposure, that NPs‐mediated modulation effectively suppresses sympathetic nervous activity (SNA) inflammatory responses, thereby preventing Importantly, no tissue injury observed post modulation. This work pioneers design long‐wave emission sonosensitizers, offering new insights regulating cardiovascular diseases.
Язык: Английский
Процитировано
0
Materials Today Communications, Год журнала: 2024, Номер unknown, С. 110742 - 110742
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0
Materials Today Chemistry, Год журнала: 2024, Номер 43, С. 102467 - 102467
Опубликована: Дек. 13, 2024
Язык: Английский
Процитировано
0