ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Hydrogel
wound
dressings
have
emerged
as
a
promising
solution
for
healing
due
to
their
excellent
mechanical
and
biochemical
properties.
Over
recent
years,
there
has
been
significant
progress
in
expanding
the
variety
of
raw
materials
used
hydrogel
formulation
along
with
development
advanced
modification
techniques
design
approaches
that
enhance
performance.
However,
comprehensive
review
encompassing
diverse
polymer
strategies
innovations
is
still
lacking
literature.
This
summarizes
use
natural
polymers
(e.g.,
chitosan,
gelatin,
sodium
alginate,
hyaluronic
acid,
dextran)
synthetic
poly(vinyl
alcohol),
polyethylene
glycol,
Pluronic
F-127,
poly(N-isopropylacrylamide),
polyacrylamide,
polypeptides)
dressings.
We
further
explore
advantages
limitations
these
discuss
various
strategies,
including
cationic
modification,
oxidative
double-bond
catechol
etc.
The
also
addresses
principles
synthesis
methods,
aligning
modifications
specific
requirements
healing.
Finally,
we
future
challenges
opportunities
hydrogel-based
Diabetes
patients
suffer
from
severe
chronic
consequences
known
as
diabetic
foot
ulcers
(DFUs),
for
which
there
are
no
particular
therapy
options.
The
inflammatory
and
oxidative
microenvironments
in
DFUs
stimulate
the
secretion
of
high
mobility
group
box-1
(HMGB1),
binds
with
receptor
advanced
glycation
endproducts
(RAGE),
causing
cascade
reactions
immune
microenvironment
(IME)
disorder,
further
exacerbating
DFU
damage.
Strategies
targeting
HMGB1-RAGE
axis
to
end
this
vicious
loop
still
lacking.
This
study
proposes
a
novel
strategy
based
on
"breathable
hydrogels"
achieve
"head
tail"
co-blocking
regulate
IME
treatments.
Specifically,
palladium
hydride
(PdH)
nanocubes
functional
structure,
hydrogel
dressing
was
prepared
double
cross-linking
network
biocompatible
alginate
polyacrylamide
modified
trehalose
network-repairing
agent.
Mechanistically,
obtained
hydrogels
can
"inhale"
excess
accumulated
reactive
oxygen
species,
inhibiting
HMGB1
secretion,
"head"
axis.
Meanwhile,
H2
"exhaled"
suppress
expression
intracellular
RAGE,
thus
blocking
breaking
cycle.
proposed
offers
highly
efficient,
safe,
facile
therapeutic
protocol
DFUs.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 25, 2025
The
skin
system
constitutes
the
human
body's
largest
organ,
acting
as
a
robust
shield
against
various
harmful
invaders,
including
microbes
and
ultraviolet
(UV)
rays
[1]
[2]
.When
is
burned,
its
barrier
function
compromised,
making
affected
areas
susceptible
to
microbial
influence,
which
can
lead
series
of
pathological
changes
in
body.
process
wound
recovery
from
burns
be
categorized
into
three
distinct
phases:
inflammatory
response,
tissue
proliferation,
remodeling
area
[3]
.
A
multitude
bacteria
multiply
rapidly
compromised
area,
during
phase
(1-2
days
after
burn),
turn
slows
down
wound's
due
formation
ulcers
[4]
During
proliferation
phase,
typically
occurs
1-2
weeks
post-burn,
site
marked
by
influx
activation
fibroblasts,
well
development
new
blood
vessels,
are
crucial
for
healing
[5]
initiates
approximately
two
following
injury
continues
number
weeks,
aimed
at
restoring
skin's
physiological
functionality
[6]
This
stage
primarily
characterized
metamorphosis
granulation
more
advanced
connective
tissue.
However,
an
overproduction
collagen
this
readily
result
scars.
Therefore,
burn
treatment
that
possesses
antibacterial
properties,
promotes
repair,
inhibits
scar
great
significance.Over
past
few
years,
there
has
been
growing
interest
versatile
potential
cold
atmospheric
plasma
(CAP)
across
fields,
such
sterilization
disinfection,
dental
cleaning,
cosmetology,
diseases,
trauma,
cancer,
attracting
widespread
attention
biomedical
field
[7][8][9]
mainly
rich
content
physiologically
active
components,
reactive
free
radicals
(ROS
RNS,
etc.),
charged
particles
(positive
negative),
electrons,
light
[7,10]
Research
found
CAP
not
only
effects
but
also
accelerate
wounds
through
stimulation
fibroblast
angiogenesis,
it
ideal
method
treating
[11][12][13][14][15][16][17][18][19]
applicant's
previous
work
combining
with
nanomedicine
third-degree
proven
functions
activity
repair
[20]
.As
type
treatment,
most
devices
currently
used
self-built
laboratories,
significant
differences
parameters
operations
between
different
devices,
resulting
inconsistent
dosage
frequency
treatment.
In
contrast,
our
research,
we
other
inherent
defects
severely
limit
application
treatment.Although
some
research
reports
indicate
risks
minimal
under
specific
conditions
[21]
,
literature
suggesting
long-term
trigger
cytotoxic
reduce
cell
viability
[22]
absence
protective
medium,
vacuum
ultraviolet/ultraviolet
radiation
significantly
contributes
-induced
DNA
damage
cytotoxicity
(accounting
70%).
While
normal
mitigate
harm
UV
stratum
corneum,
burned
lack
[23]
caused
manifested
as:
(1)
impair
macromolecules
within
cells
(proteins,
lipids,
nucleic
acids,
inducing
cellular
[24]
;
(2)
It
destroys
elastic
fibers,
accelerating
aging
slowing
[25]
(3)
By
forming
pyrimidine
dimers
damages,
leads
cancer
[26][27]
These
hazards
drug
administration
thereby
affecting
speed
recovery.
Although
existing
noted
improved
suppress
generation
light,
weakened
intensity
how
effectively
filter
out
while
retaining
remains
challenge.There
approaches
address
issue.
first
involves
utilizing
instrument
leverages
linear
propagation
characteristics
majority
light.
approach
may,
extent,
diminish
quantity
ions
reach
target
site.
second
idea
develop
adjuvant
capable
absorbing
akin
sunscreen.
ensure
selected
sunscreen
does
react
ROS
or
reactions
could
compromise
overall
CAP.A
high
flow
rate
gas
make
extremely
dry
[28]
[29]
contradicts
theory
moist
hinders
healing,
preventing
fully
exerting
promoting
inhibiting
scarring.A
environment
facilitates
natural
autolytic
debridement,
alleviates
pain,
minimizes
scarring,
stimulates
production,
encourages
migration
keratinocytes
bed,
thus
collectively
contributing
enhanced
[30]
On
hand,
least
four
disadvantages:
Excessive
dryness
dehydrate
traumatized
tissue,
leading
further
unfavorable
eschar,
difficult
epithelial
move,
prolonging
time
[31]
infection
[32]
Larger
scars
produced
[33]
(4)
intensifies
patient's
pain
[34]
when
using
another
issue
needs
addressed
brought
about
gas.
Certainly,
feasible
strike
balance
efficacy
minimization
fine-tuning
threshold.
Nevertheless,
equilibrium
merely
replicates
exposure
therapy
falls
considerably
short
attaining
optimal
state
wet
healing.
this,
question
emerges:
integrate
hydrogel,
hydrosol,
relevant
materials
actualize
dual
benefit
combined
treatment?In
Opinion,
have
summarized
Most
studies
reported
high-speed
rarely
performed.
issues
fundamental
problem
solved
use
treatment.In
view
challenges
associated
radiation,
innovative
instruments
devised
rays.
Additionally,
drugs
might
developed,
leveraging
traits
absorb
radiation.
When
comes
drying
high-flow-rate
gas,
design
hydrogels,
hydrosols,
related
substances
explored
facilitate
Opinion
piece
offers
novel
vantage
point
utilization
treatments,
carrying
theoretical
practical
implications
exploration
therapeutic
burns.
