Talanta, Год журнала: 2024, Номер 282, С. 127074 - 127074
Опубликована: Окт. 18, 2024
Язык: Английский
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
Abstract Infections caused by drug‐resistant bacteria represent a major contributor to high mortality rates, underscoring the urgent need for effective non‐antibiotic drugs and alternative therapies. Antimicrobial photodynamic therapy (aPDT) emerges as an innovative treatment due its minimal drug resistance. Herein, series of Nile Red derivatives is synthesized donor engineering strategy. Notably, NTPA featuring triphenylamine (TPA) electron‐donating group, exhibited highest production reactive oxygen species (ROS). The enhanced electron donating‐accepting (D‐A) property effectively reduced energy gap between S 1 T (ΔE S‐T ), facilitating intersystem crossing (ISC) with larger spin‐orbit coupling (SOC) constant. Furthermore, twisted conformation profoundly suppressed quenching ROS. As expected, over 470‐fold increase in ROS observed, predominantly comprising type‐I nanoparticles (NPs) exceptional vitro killing ability against various bacteria, inhibition efficiency even reaching 99.9%. In methicillin‐resistant staphylococcus aureus (MRSA)‐induced abscess model, NPs facilitated complete wound healing within just 8 days following single administration irradiation, highlighting their bactericidal wound‐healing promotion capabilities. Overall, this work inspired construction efficient Red‐based photosensitizers (PSs) development new broad‐spectrum aPDT method treatment.
Язык: Английский
Процитировано
1
International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 124995 - 124995
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
4
Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(12)
Опубликована: Дек. 1, 2024
ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.
Язык: Английский
Процитировано
4
Molecular Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain customizable designs, making them suitable personalized medicine. Understanding the key design parameters challenges during contact biofluids is crucial to optimizing their use across applications. This review summarizes current fabrication techniques considerations tailored meet distinct requirements biosensing We further underscore state of theranostic that integrate propose future directions advancing toward clinical use.
Язык: Английский
Процитировано
0
Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123322 - 123322
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160385 - 160385
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Фев. 17, 2025
The increasing prevalence of multidrug-resistant bacteria is a significant global health threat. In contrast to conventional antibiotic treatments, photodynamic therapy (PDT) offers promising alternative by reducing the bacterial adaptability antibiotics and bactericides. However, traditional photosensitizers encounter poor antimicrobial efficacy due hydrophilicity photosensitizers, short lifespan, narrow diffusion radius reactive oxygen species (ROS), risk exacerbating inflammation. this study, we report bacterial-targeting supramolecular nanophotosensitizer for combating multidrug resistant bacteria. nanophotosensitizer, formed through host–guest interactions self-assembly tetra-cyclodextrin-modified silver porphyrin (AgTPP-CD4), adamantyl-modified phenylboronic acid (Ad-PBA), curcumin (Cur), can effectively target kill methicillin-resistant Staphylococcus aureus (MRSA). Moreover, it reduces inflammation promotes wound healing in MRSA-infected wounds without inducing drug resistance. combination chemistry targeted PDT strategy infections.
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2025, Номер 48, С. 474 - 492
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
0
Bioorganic Chemistry, Год журнала: 2025, Номер unknown, С. 108412 - 108412
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0