Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy DOI

Jizhong Shi,

Manshan Liang,

Yeting Qiu

et al.

Talanta, Journal Year: 2024, Volume and Issue: 282, P. 127074 - 127074

Published: Oct. 18, 2024

Language: Английский

Triphenylamine‐Substituted Nile Red Derivatives with Efficient Reactive Oxygen Species Generation for Robust and Broad‐Spectrum Antimicrobial Photodynamic Therapy and Abscess Wound Healing DOI Open Access
Jianan Dai, Laiping Fang,

Zhijin Fan

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Infections caused by drug‐resistant bacteria represent a major contributor to high mortality rates, underscoring the urgent need for effective non‐antibiotic drugs and alternative therapies. Antimicrobial photodynamic therapy (aPDT) emerges as an innovative treatment due its minimal drug resistance. Herein, series of Nile Red derivatives is synthesized donor engineering strategy. Notably, NTPA featuring triphenylamine (TPA) electron‐donating group, exhibited highest production reactive oxygen species (ROS). The enhanced electron donating‐accepting (D‐A) property effectively reduced energy gap between S 1 T (ΔE S‐T ), facilitating intersystem crossing (ISC) with larger spin‐orbit coupling (SOC) constant. Furthermore, twisted conformation profoundly suppressed quenching ROS. As expected, over 470‐fold increase in ROS observed, predominantly comprising type‐I nanoparticles (NPs) exceptional vitro killing ability against various bacteria, inhibition efficiency even reaching 99.9%. In methicillin‐resistant staphylococcus aureus (MRSA)‐induced abscess model, NPs facilitated complete wound healing within just 8 days following single administration irradiation, highlighting their bactericidal wound‐healing promotion capabilities. Overall, this work inspired construction efficient Red‐based photosensitizers (PSs) development new broad‐spectrum aPDT method treatment.

Language: Английский

Citations

1
Recent progress in the 3D printing of microneedle patches for biomedical applications DOI
Huan Liu,

Aminov Nail,

Decheng Meng

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124995 - 124995

Published: Nov. 1, 2024

Language: Английский

Citations

4
Smart Microneedles in Biomedical Engineering: Harnessing Stimuli‐Responsive Polymers for Novel Applications DOI

Farangis Shahi,

Hana Afshar,

Elmuez A. Dawi

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.

Language: Английский

Citations

4
Tailoring Design of Microneedles for Drug Delivery and Biosensing DOI

Yuexi Lin,

Muamer Dervisevic, Hao Zhe Yoh

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain customizable designs, making them suitable personalized medicine. Understanding the key design parameters challenges during contact biofluids is crucial to optimizing their use across applications. This review summarizes current fabrication techniques considerations tailored meet distinct requirements biosensing We further underscore state of theranostic that integrate propose future directions advancing toward clinical use.

Language: Английский

Citations

0
Phenylboronic Acid-Modified Carbon Dot-Proteinase K Nanohybrids for Enhanced Photodynamic Therapy Against Bacterial Biofilm Infections DOI
Haoyi Sun, Shan Sun,

Henggang Wang

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
pH-responsive and self-adaptive injectable sodium alginate/carboxymethyl chitosan hydrogel accelerates infected wound healing by bacteriostasis and immunomodulation DOI
Xi Zhang,

Yongzhe Liu,

Ziwei Wang

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123322 - 123322

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multipurpose β-Cyclodextrin-Involved nanospherical Aggregates: Self-Assembly Process, foliar Adhesion, and promising applications for kiwifruit and rice Protections DOI
Pan Liu, Jinghan Yang,

Juan Liu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160385 - 160385

Published: Feb. 1, 2025

Language: Английский

Citations

0
A Bacteria-Targeting Supramolecular Nanophotosensitizer for Combating Multidrug Resistant Bacteria DOI
Wenlong Huang,

Anan Wang,

Wang Wen-chen

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

The increasing prevalence of multidrug-resistant bacteria is a significant global health threat. In contrast to conventional antibiotic treatments, photodynamic therapy (PDT) offers promising alternative by reducing the bacterial adaptability antibiotics and bactericides. However, traditional photosensitizers encounter poor antimicrobial efficacy due hydrophilicity photosensitizers, short lifespan, narrow diffusion radius reactive oxygen species (ROS), risk exacerbating inflammation. this study, we report bacterial-targeting supramolecular nanophotosensitizer for combating multidrug resistant bacteria. nanophotosensitizer, formed through host–guest interactions self-assembly tetra-cyclodextrin-modified silver porphyrin (AgTPP-CD4), adamantyl-modified phenylboronic acid (Ad-PBA), curcumin (Cur), can effectively target kill methicillin-resistant Staphylococcus aureus (MRSA). Moreover, it reduces inflammation promotes wound healing in MRSA-infected wounds without inducing drug resistance. combination chemistry targeted PDT strategy infections.

Language: Английский

Citations

0
Advanced biomaterials for targeting mature biofilms in periodontitis therapy DOI
Jie Tao,

Yirong Sun,

Guoliang Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 474 - 492

Published: Feb. 27, 2025

Language: Английский

Citations

0
Cationic AIEgens with large rigid π-planes: Specific bacterial imaging and treatment of drug-resistant bacterial infections DOI

Senlin Peng,

Zhou Xu,

Qian Wang

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108412 - 108412

Published: March 1, 2025

Language: Английский

Citations

0