Emerging Piezoelectric Sonosensitizer for ROS-Driven Sonodynamic Cancer Therapy
Inorganics,
Год журнала:
2025,
Номер
13(3), С. 71 - 71
Опубликована: Фев. 26, 2025
As
a
non-invasive
modality,
sonodynamic
therapy
(SDT)
offers
several
advantages
in
cancer
treatment,
including
deep
tissue
penetration
and
precise
spatiotemporal
control,
resulting
from
the
interplay
between
low-intensity
ultrasound
sonosensitizers.
Piezoelectric
materials,
known
for
their
remarkable
capacity
of
interconversion
mechanical
electrical
energy,
have
garnered
considerable
attention
biomedical
applications,
which
can
serve
as
pivotal
sonosensitizers
SDT.
These
materials
generate
internal
electric
fields
via
ultrasound-induced
deformation,
modulates
alteration
charge
carriers,
thereby
initiating
surface
redox
reactions
to
reactive
oxygen
species
(ROS)
realizing
therapeutic
efficacy
This
review
provides
an
in-depth
exploration
piezoelectric
utilized
SDT,
with
particular
emphasis
on
recent
innovations,
elucidation
underlying
mechanisms,
optimization
strategies
advanced
materials.
Furthermore,
incorporation
immunotherapy,
photodynamic,
chemodynamic,
chemotherapy
is
explored,
emphasizing
potential
enhance
outcomes.
By
examining
basic
principles
effect
its
contributions
this
sheds
light
promising
applications
oncology.
It
also
highlights
future
directions
improving
these
expanding
clinical
utility
tumor
therapy.
Язык: Английский
Hetero‐Trimetallic Atom Catalysts Enable Targeted ROS Generation and Redox Signaling for Intensive Apoptosis and Ferroptosis
Siyi Li,
E Jiaoting,
Xiucheng Zhao
и другие.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 23, 2025
Abstract
Reactive
oxygen
species
(ROS)
play
crucial
roles
in
cellular
metabolic
processes
by
acting
as
primary
intracellular
chemical
substrates
and
secondary
messengers
for
signal
modulation.
However,
the
artificial
engineering
of
nanozymes
to
generate
ROS
is
restricted
their
low
catalytic
efficiency,
high
toxicity,
off‐target
consumption.
Herein,
hetero‐trimetallic
atom
catalysts
(TACs)
anchored
on
a
stable
symmetrical
pyramid
structure
are
designed
presence
N
P
surface
ligands
from
cross‐linked
polyphosphazene
interlayer‐coated
MIL‐101(Fe).
The
3D
network
TACs
with
uniform
dispersion
Cu,
Co,
Fe
hetero‐single
atoms
effectively
tailor
active
sites
avoid
metal
sintering,
thereby
providing
sufficient
activity
blooms.
Nanovesicle
membranes
facilitate
accumulation
homologous
targeting,
recognition,
endocytosis,
addressing
potentially
toxicity
defects.
Therefore,
outcome
situ
ROS‐bloom
acts
redox
directly
regulating
oxidative
stress
tumor
microenvironment.
Meanwhile,
intervene
glutathione
peroxidase
4,
long‐chain
acyl‐CoA
synthetase
cysteinyl
aspartate
specific
proteinase‐3
pathways
second
messengers,
fostering
proclivity
toward
apoptosis
lipid
peroxidation‐regulated
ferroptosis
pathway
concurrently,
highlighting
application
prospects
biomedical
field.
Язык: Английский
Pt–PtTe2 Nanoparticles with Heterojunction-Based Accelerated Electron Transfer for Efficient Tumor Therapy
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
Язык: Английский
Sono-blasting Triggered Cascading-Amplification of Oxidative Stress for Enhanced Interventional Therapy of Hepatocellular Carcinoma
Nano Letters,
Год журнала:
2024,
Номер
24(29), С. 8996 - 9003
Опубликована: Июль 12, 2024
Interventional
therapy
is
widely
regarded
as
a
highly
promising
treatment
approach
for
nonsurgical
liver
cancer.
However,
the
development
of
drug
resistance
and
tolerance
to
hypoxic
environments
after
embolization
can
lead
increased
angiogenesis,
enhanced
tumor
cell
stemness,
greater
invasiveness,
resulting
in
metastasis
recurrence.
To
address
these
challenges,
novel
involving
use
lecithin
DSPE-PEG
comodified
Ca
Язык: Английский
Ultrasound‐Activated Precise Sono‐Immunotherapy for Breast Cancer with Reduced Pulmonary Fibrosis
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Abstract
Immune
checkpoint
inhibitors
have
demonstrated
remarkable
efficacy
across
various
cancer
types.
However,
immune‐related
adverse
events
(irAEs)
pose
a
significant
challenge
in
immunotherapy,
particularly
the
associated
pneumonia
as
primary
reaction,
which
can
lead
to
irreversible
pulmonary
fibrosis.
Additionally,
monotherapy
with
programmed
death
ligand
(PD‐L1)
has
shown
limited
effectiveness.
Therefore,
improve
response
rate
of
immunotherapy
and
reduce
fibrosis,
this
study
designed
prepared
an
intelligent
nanodrug
based
on
dendritic
mesoporous
silica
nanoparticles
(DMSNs)
loaded
sono‐sensitive
agent
protoporphyrin
IX
(PpIX).
reactive
oxygen
species
(ROS)
sensitive
linker
is
used
attach
immunotherapeutic
drug
PD‐L1
inhibitor
(aPD‐L1)
DMSNs
via
covalent
bonds.
The
external
ultrasound
(US)
activates
PpIX
generate
ROS,
breaks
release
aPD‐L1
induce
sonodynamic
therapy
(SDT)
immunotherapy.
This
sono‐immnotherapy
approach
excellent
outcomes
tumor
inhibition,
eliciting
immune
responses,
reducing
Overall,
offers
new,
efficient,
safe
method
for
breast
treatment,
expands
application
Язык: Английский