Emerging Piezoelectric Sonosensitizer for ROS-Driven Sonodynamic Cancer Therapy

Inorganics, Journal Year: 2025, Volume and Issue: 13(3), P. 71 - 71

Published: Feb. 26, 2025

As a non-invasive modality, sonodynamic therapy (SDT) offers several advantages in cancer treatment, including deep tissue penetration and precise spatiotemporal control, resulting from the interplay between low-intensity ultrasound sonosensitizers. Piezoelectric materials, known for their remarkable capacity of interconversion mechanical electrical energy, have garnered considerable attention biomedical applications, which can serve as pivotal sonosensitizers SDT. These materials generate internal electric fields via ultrasound-induced deformation, modulates alteration charge carriers, thereby initiating surface redox reactions to reactive oxygen species (ROS) realizing therapeutic efficacy This review provides an in-depth exploration piezoelectric utilized SDT, with particular emphasis on recent innovations, elucidation underlying mechanisms, optimization strategies advanced materials. Furthermore, incorporation immunotherapy, photodynamic, chemodynamic, chemotherapy is explored, emphasizing potential enhance outcomes. By examining basic principles effect its contributions this sheds light promising applications oncology. It also highlights future directions improving these expanding clinical utility tumor therapy.

Language: Английский

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Hetero‐Trimetallic Atom Catalysts Enable Targeted ROS Generation and Redox Signaling for Intensive Apoptosis and Ferroptosis

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Abstract Reactive oxygen species (ROS) play crucial roles in cellular metabolic processes by acting as primary intracellular chemical substrates and secondary messengers for signal modulation. However, the artificial engineering of nanozymes to generate ROS is restricted their low catalytic efficiency, high toxicity, off‐target consumption. Herein, hetero‐trimetallic atom catalysts (TACs) anchored on a stable symmetrical pyramid structure are designed presence N P surface ligands from cross‐linked polyphosphazene interlayer‐coated MIL‐101(Fe). The 3D network TACs with uniform dispersion Cu, Co, Fe hetero‐single atoms effectively tailor active sites avoid metal sintering, thereby providing sufficient activity blooms. Nanovesicle membranes facilitate accumulation homologous targeting, recognition, endocytosis, addressing potentially toxicity defects. Therefore, outcome situ ROS‐bloom acts redox directly regulating oxidative stress tumor microenvironment. Meanwhile, intervene glutathione peroxidase 4, long‐chain acyl‐CoA synthetase cysteinyl aspartate specific proteinase‐3 pathways second messengers, fostering proclivity toward apoptosis lipid peroxidation‐regulated ferroptosis pathway concurrently, highlighting application prospects biomedical field.

Language: Английский

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Pt–PtTe₂ Nanoparticles with Heterojunction-Based Accelerated Electron Transfer for Efficient Tumor Therapy

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

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Sono-blasting Triggered Cascading-Amplification of Oxidative Stress for Enhanced Interventional Therapy of Hepatocellular Carcinoma

Nano Letters, Journal Year: 2024, Volume and Issue: 24(29), P. 8996 - 9003

Published: July 12, 2024

Interventional therapy is widely regarded as a highly promising treatment approach for nonsurgical liver cancer. However, the development of drug resistance and tolerance to hypoxic environments after embolization can lead increased angiogenesis, enhanced tumor cell stemness, greater invasiveness, resulting in metastasis recurrence. To address these challenges, novel involving use lecithin DSPE-PEG comodified Ca

Language: Английский

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Ultrasound‐Activated Precise Sono‐Immunotherapy for Breast Cancer with Reduced Pulmonary Fibrosis

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Immune checkpoint inhibitors have demonstrated remarkable efficacy across various cancer types. However, immune‐related adverse events (irAEs) pose a significant challenge in immunotherapy, particularly the associated pneumonia as primary reaction, which can lead to irreversible pulmonary fibrosis. Additionally, monotherapy with programmed death ligand (PD‐L1) has shown limited effectiveness. Therefore, improve response rate of immunotherapy and reduce fibrosis, this study designed prepared an intelligent nanodrug based on dendritic mesoporous silica nanoparticles (DMSNs) loaded sono‐sensitive agent protoporphyrin IX (PpIX). reactive oxygen species (ROS) sensitive linker is used attach immunotherapeutic drug PD‐L1 inhibitor (aPD‐L1) DMSNs via covalent bonds. The external ultrasound (US) activates PpIX generate ROS, breaks release aPD‐L1 induce sonodynamic therapy (SDT) immunotherapy. This sono‐immnotherapy approach excellent outcomes tumor inhibition, eliciting immune responses, reducing Overall, offers new, efficient, safe method for breast treatment, expands application

Language: Английский

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