Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Abstract
The
distribution
of
electrical
potentials
and
current
in
exogenous
electrostimulation
has
significant
impacts
on
its
effectiveness
promoting
tissue
repair.
However,
there
is
still
a
lack
flexible,
implantable
power
source
capable
generating
customizable
patterned
electric
fields
for
situ
electrostimulation(electrical
stimulation).
Herein,
this
study
reports
fuel
cell
patch
(FCP)
that
can
provide
hypoxic
microenvironment
to
promote
repair
synergistically.
Stable
highly
efficient
PtNi
nanochains
nanocages
electrocatalysts
with
anti‐interference
properties
catalyze
glucose
oxidation
oxygen
reduction
respectively
an
encapsulation‐free
cell.
laser‐induced
graphene
(LIG)
electrode
loaded
transferred
the
surface
flexible
chitosan
hydrogel.
resulting
FCP
adapt
tissues
different
morphologies,
firmly
adhere
prevent
suturing,
potent
(0.403
V,
51.55
µW
cm
−2
).
Additionally,
it
consumes
create
microenvironment,
increasing
expression
hypoxia‐inducible
factor‐1α
(HIF‐1α).
Based
pattern
requirements
during
various
types
tissue,
axial
peripheral
nerves
flower‐patterned
myocardial
are
constructed
transplanted
into
animals,
showing
both
models.
Abstract
Physiological
wound
healing
process
can
restore
the
functional
and
structural
integrity
of
skin,
but
is
often
delayed
due
to
external
disturbance.
The
development
methods
for
promoting
repair
skin
wounds
represents
a
highly
desired
challenging
goal.
Here,
flexible,
self‐powered,
multifunctional
triboelectric
nanogenerator
(TENG)
patch
(e‐patch)
presented
accelerating
through
synergy
electrostimulation
photothermal
effect.
To
fabricate
e‐patch,
flexible
conductive
hydrogel
with
dual
network
polyacrylamide
(PAM)
polydopamine
(PDA)
synthesized
doped
multi‐walled
carbon
nanotubes
(MCNTs).
exhibits
high
conductivity,
good
stretchability,
biocompatibility.
e‐patch
assembled
from
detect
mechanical
electrical
signals
human
motions
in
real‐time
manner.
In
rodent
model
full‐thickness
dorsal
wound,
integrating
self‐driven
effect
under
near‐infrared
light
irradiation
efficiently
promotes
hair
follicle
regeneration
relieving
inflammation,
fastening
collagen
deposition,
vascular
regeneration,
epithelialization.
It
offers
promising
way
accelerate
healing.
Abstract
Wound
healing
is
a
complex
process
that
involves
multiple
stages
and
susceptible
to
various
challenges,
such
as
infection,
insufficient
blood
flow,
the
body's
inadequate
response
process,
which
can
be
life‐threatening
for
patient.
In
current
medical
landscape,
traditional
treatments
often
struggle
meet
high
standards
of
modern
care.
Therefore,
it
crucial
actively
explore
develop
new
drugs
or
advanced
technologies
enhance
bacterially
infected
wounds.
recent
years,
several
physical
methods
effectively
accelerate
wound
have
garnered
widespread
attention
interest.
Among
these,
Photothermal
therapy
(PTT)
has
been
extensively
utilized
in
treatment
bacterial
infections
due
its
non‐invasive,
low
toxicity,
ease
use.
The
photothermal
agents
(PTAs)
serve
core
material
PTT,
their
efficacy
significantly
influenced
by
specific
PTAs
employed.
Selecting
appropriate
essential
achieving
desired
therapeutic
effect.
This
relies
on
PTAs's
ability
efficiently
convert
wavelengths
light
energy
into
heat
upon
absorption,
thereby
generating
thermal
effect
at
site.
Consequently,
properties
PTAs,
including
conversion
efficiency,
biocompatibility,
stability
within
organism,
are
critical
factors
determine
outcome.
review
introduces
organic,
inorganic,
organic‐inorganic
hybrid
PTT
healing,
highlighting
main
applications
management
years.
Finally,
we
briefly
discuss
limitations
prospects
this
field.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
279, С. 134578 - 134578
Опубликована: Авг. 8, 2024
Because
of
the
complex
symptoms
resulting
from
metabolic
dysfunction
in
wound
microenvironment
during
bacterial
infections,
along
with
necessity
to
combat
free
radicals,
achieving
prompt
and
thorough
healing
remains
a
significant
medical
challenge
that
has
yet
be
fully
addressed.
Moreover,
misuse
common
antibiotics
contributed
emergence
drug-resistant
bacteria,
underscoring
need
for
enhancements
practical
commonly
utilized
approach
treatment.
In
this
context,
hydrogel
dressings
based
on
biological
macromolecules
antibacterial
antioxidant
properties
present
promising
new
avenue
skin
treatment
due
their
multifunctional
characteristics.
Despite
considerable
potential
innovative
care,
comprehensive
research
these
is
still
insufficient.
Consequently,
development
advanced
macromolecule-based
hydrogels,
such
as
chitosan,
alginate,
cellulose,
hyaluronic
acid,
others,
been
primary
focus
study.
These
materials
have
enriched
various
agents
confer
attributes
purposes.
This
review
article
aims
offer
overview
latest
progress
field,
providing
critical
theoretical
basis
future
advancements
utilization
hydrogels
healing.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Abstract
Effective
glycemic
control
is
paramount
for
optimal
wound
healing
in
diabetic
patients.
Traditional
antibacterial
and
anti‐inflammatory
treatments,
while
important,
often
fall
short
addressing
the
hyperglycemic
conditions
of
wounds.
Therefore,
development
novel
therapeutic
strategies
accelerating
has
garnered
escalating
attention.
Covalent
organic
frameworks
(COFs)
are
an
emerging
class
crystalline
porous
polymers
constructed
through
strong
covalent
bonds.
Their
exceptional
structural
tunability
renders
them
as
ideal
platform
advanced
applications.
Herein,
two
redox‐responsive
Zn(II)‐coordinated
porphyrin
COF
hydrogels
constructed,
which
demonstrate
rapid
blood
glucose
reduction
localized
tissues,
along
with
improved
angiogenesis,
reactive
oxygen
species
(ROS)
scavenging,
photothermal
antimicrobial
capacities
within
environment
patients,
thereby
effectively
controlling
infections
concurrently
promoting
healing.
Specifically,
COFs
built‐in
dual
active
sites,
i.e.,
disulfide
or
diselenide
moieties,
can
be
cleaved
by
ROS,
releasing
Zn(II)
ions
that
possess
tissue‐repairing
properties.
Furthermore,
Zn(II)‐porphyrin
exhibits
oxidase
(GOX)‐like
activity,
catalyzing
conversion
into
non‐glucose
metabolites.
This
synergistic
combination
glucose‐responsive
release
GOX‐like
activities
restores
tissue
redox
balance
improves
microenvironment,
offering
a
promising
strategy
diagnosis
treatment
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101553 - 101553
Опубликована: Фев. 5, 2025
Wounds
infected
by
bacteria
pose
a
considerable
challenge
in
the
field
of
healthcare,
particularly
with
increasing
prevalence
antibiotic-resistant
pathogens.
Traditional
antibiotics
often
fail
to
achieve
effective
results
due
limited
penetration,
resistance
development,
and
inadequate
local
concentration
at
wound
sites.
These
limitations
necessitate
exploration
alternative
strategies
that
can
overcome
drawbacks
conventional
therapies.
Nanomaterials
have
emerged
as
promising
solution
for
tackling
bacterial
infections
facilitating
healing,
thanks
their
distinct
physicochemical
characteristics
multifunctional
capabilities.
This
review
highlights
latest
developments
nanomaterials
demonstrated
enhanced
antibacterial
efficacy
improved
healing
outcomes.
The
mechanisms
are
varied,
including
ion
release,
chemodynamic
therapy,
photothermal/photodynamic
electrostatic
interactions,
delivery
drugs,
which
not
only
combat
but
also
address
challenges
posed
biofilms
antibiotic
resistance.
Furthermore,
these
create
an
optimal
environment
tissue
regeneration,
promoting
faster
closure.
By
leveraging
unique
attributes
nanomaterials,
there
is
significant
opportunity
revolutionize
management
wounds
markedly
improve
patient
Diabetic
wounds
are
highly
susceptible
to
bacterial
infection,
which
can
lead
the
formation
of
biofilms,
making
diabetic
wound
healing
a
major
challenge.
In
this
study,
composited
microneedle
that
incorporated
drug-loaded
conjugated
polymer
nanoparticles
and
basic
fibroblast
growth
factor
was
prepared
eliminate
biofilms
promote
vascular
regeneration.
This
released
minocycline
under
near-infrared
(NIR)
light,
effectively
penetrating
biofilms.
The
photothermal
properties
polymers,
combined
with
antibacterial
action
minocycline,
contribute
eradication
elimination
drug-resistant
bacteria.
Moreover,
it
regulated
microenvironment
by
reducing
level
oxidative
stress,
as
well
production
inflammatory
factors
at
site.
Meanwhile,
boosted
cell
migration
promoted
angiogenesis
accelerate
healing.
for
biofilm
represents
promising
approach
promoting
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Effective
treatment
of
diabetic
wounds
remains
challenging
because
multidrug-resistant
(MDR)
bacterial
infections,
excessive
oxidative
stress,
and
impaired
angiogenesis.
In
this
study,
a
tissue-adhesive
antibacterial
hydrogel
incorporating
MXene
deferoxamine
(DFO)-loaded
microspheres
is
developed
for
the
MDR
bacteria-infected
wounds.
The
built
based
on
covalent
crosslinking
between
ε-poly(L-lysine)
o-phthalaldehyde-terminated
four-arm
poly(ethylene
glycol).
exhibited
excellent
mechanical
properties,
tissue
adhesion
strength,
biocompatibility,
biodegradability.
Under
near-infrared
(NIR)
irradiation,
converted
light
into
heat
elevated
local
temperature
rapidly,
enabling
rapid
disintegration
biofilms.
Simultaneously,
exerted
inherent
activity,
persistently
killing
planktonic
bacteria,
effectively
controlling
wound
infections.
encapsulated
DFO
then
released
from
in
sustained
controlled
manner,
promoted
angiogenesis
during
healing.
Additionally,
MXenes
can
scavenge
reactive
oxygen
species
alleviate
inflammation.
methicillin-resistant
Staphylococcus
aureus-infected
model
mice,
composite
along
with
NIR
irradiation
efficiently
reduced
infectious
accelerated
healing
by
promoting
alleviating
This
has
great
clinical
potential
wounds,
particularly
environments
involving
motion
infection.
