Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
Abstract
Cisplatin‐induced
ototoxicity
is
attributed
to
the
aberrant
accumulation
of
reactive
oxygen
species
(ROS)
within
inner
ear.
Antioxidants
represented
by
α‐lipoic
acid
(ALA)
have
been
demonstrated
scavenge
ROS
in
cochlea,
while
effective
delivery
these
agents
vivo
remains
a
major
challenge.
Here,
novel
polydopamine
(PDA)
nanogel
decorated
adhesive
and
responsive
hierarchical
microcarriers
for
controllable
presented
ALA
deafness
prevention.
As
composite
exhibit
excellent
bioadhesion
capabilities,
this
can
result
prolonged
retention
time
allow
precise
under
light
stimulation,
which
significantly
enhances
therapeutic
efficacy
ALA.
Based
on
features,
both
vitro
experiments
are
that
combined
with
near‐infrared
irradiation
effectively
attenuate
cisplatin‐induced
ototoxicity.
These
findings
suggest
viable
approach
ear
medication
prevention
deafness.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
279, P. 134578 - 134578
Published: Aug. 8, 2024
Because
of
the
complex
symptoms
resulting
from
metabolic
dysfunction
in
wound
microenvironment
during
bacterial
infections,
along
with
necessity
to
combat
free
radicals,
achieving
prompt
and
thorough
healing
remains
a
significant
medical
challenge
that
has
yet
be
fully
addressed.
Moreover,
misuse
common
antibiotics
contributed
emergence
drug-resistant
bacteria,
underscoring
need
for
enhancements
practical
commonly
utilized
approach
treatment.
In
this
context,
hydrogel
dressings
based
on
biological
macromolecules
antibacterial
antioxidant
properties
present
promising
new
avenue
skin
treatment
due
their
multifunctional
characteristics.
Despite
considerable
potential
innovative
care,
comprehensive
research
these
is
still
insufficient.
Consequently,
development
advanced
macromolecule-based
hydrogels,
such
as
chitosan,
alginate,
cellulose,
hyaluronic
acid,
others,
been
primary
focus
study.
These
materials
have
enriched
various
agents
confer
attributes
purposes.
This
review
article
aims
offer
overview
latest
progress
field,
providing
critical
theoretical
basis
future
advancements
utilization
hydrogels
healing.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Abstract
Wound
healing
is
a
complex
process
that
involves
multiple
stages
and
susceptible
to
various
challenges,
such
as
infection,
insufficient
blood
flow,
the
body's
inadequate
response
process,
which
can
be
life‐threatening
for
patient.
In
current
medical
landscape,
traditional
treatments
often
struggle
meet
high
standards
of
modern
care.
Therefore,
it
crucial
actively
explore
develop
new
drugs
or
advanced
technologies
enhance
bacterially
infected
wounds.
recent
years,
several
physical
methods
effectively
accelerate
wound
have
garnered
widespread
attention
interest.
Among
these,
Photothermal
therapy
(PTT)
has
been
extensively
utilized
in
treatment
bacterial
infections
due
its
non‐invasive,
low
toxicity,
ease
use.
The
photothermal
agents
(PTAs)
serve
core
material
PTT,
their
efficacy
significantly
influenced
by
specific
PTAs
employed.
Selecting
appropriate
essential
achieving
desired
therapeutic
effect.
This
relies
on
PTAs's
ability
efficiently
convert
wavelengths
light
energy
into
heat
upon
absorption,
thereby
generating
thermal
effect
at
site.
Consequently,
properties
PTAs,
including
conversion
efficiency,
biocompatibility,
stability
within
organism,
are
critical
factors
determine
outcome.
review
introduces
organic,
inorganic,
organic‐inorganic
hybrid
PTT
healing,
highlighting
main
applications
management
years.
Finally,
we
briefly
discuss
limitations
prospects
this
field.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Physiological
wound
healing
process
can
restore
the
functional
and
structural
integrity
of
skin,
but
is
often
delayed
due
to
external
disturbance.
The
development
methods
for
promoting
repair
skin
wounds
represents
a
highly
desired
challenging
goal.
Here,
flexible,
self‐powered,
multifunctional
triboelectric
nanogenerator
(TENG)
patch
(e‐patch)
presented
accelerating
through
synergy
electrostimulation
photothermal
effect.
To
fabricate
e‐patch,
flexible
conductive
hydrogel
with
dual
network
polyacrylamide
(PAM)
polydopamine
(PDA)
synthesized
doped
multi‐walled
carbon
nanotubes
(MCNTs).
exhibits
high
conductivity,
good
stretchability,
biocompatibility.
e‐patch
assembled
from
detect
mechanical
electrical
signals
human
motions
in
real‐time
manner.
In
rodent
model
full‐thickness
dorsal
wound,
integrating
self‐driven
effect
under
near‐infrared
light
irradiation
efficiently
promotes
hair
follicle
regeneration
relieving
inflammation,
fastening
collagen
deposition,
vascular
regeneration,
epithelialization.
It
offers
promising
way
accelerate
healing.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 6, 2025
Diabetic
wounds
are
highly
susceptible
to
bacterial
infection,
which
can
lead
the
formation
of
biofilms,
making
diabetic
wound
healing
a
major
challenge.
In
this
study,
composited
microneedle
that
incorporated
drug-loaded
conjugated
polymer
nanoparticles
and
basic
fibroblast
growth
factor
was
prepared
eliminate
biofilms
promote
vascular
regeneration.
This
released
minocycline
under
near-infrared
(NIR)
light,
effectively
penetrating
biofilms.
The
photothermal
properties
polymers,
combined
with
antibacterial
action
minocycline,
contribute
eradication
elimination
drug-resistant
bacteria.
Moreover,
it
regulated
microenvironment
by
reducing
level
oxidative
stress,
as
well
production
inflammatory
factors
at
site.
Meanwhile,
boosted
cell
migration
promoted
angiogenesis
accelerate
healing.
for
biofilm
represents
promising
approach
promoting
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Abstract
Smart
hydrogels
with
multi‐fluorescent
properties
hold
great
promise
for
information
encryption.
However,
conventional
fluorescent
often
lack
adequate
mechanical
and
multiple
responsiveness,
limiting
their
range
of
applications.
In
this
study,
a
multifunctional
hydrogel
featuring
an
interpenetrating
polymer
network
(IPN)
composed
poly(vinyl
alcohol)
(PVA)
poly(acrylic
amide‐co‐2‐acrylamido‐2‐methylpropane
sulfonic
acid)
P(AM/AMPS)
chemical
cross‐linking
networks
is
designed.
Through
the
coordination
lanthanide
ions
(Eu
3+
,
Tb
)
glycine,
achieves
exceptional
stretchability
(over
900%)
adjustable
photoluminescence
properties.
Due
to
acid
groups
on
2‐acrylamide‐2‐methylpropanesulfonic
(AMPS),
which
support
various
noncovalent
interactions,
PVA‐P(AM/AMPS)‐Gly‐Ln
displays
strong
reversible
adhesive
diverse
substrates.
Ultimately,
assembled
into
multifunctional,
flexible
sensor,
boasting
satisfactory
sensitivity
(GF
=
5.3),
rapid
response
rate
(100
ms),
outstanding
characteristics,
highlighting
its
potential
applications
in
human
motion
detection
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Abstract
Effective
glycemic
control
is
paramount
for
optimal
wound
healing
in
diabetic
patients.
Traditional
antibacterial
and
anti‐inflammatory
treatments,
while
important,
often
fall
short
addressing
the
hyperglycemic
conditions
of
wounds.
Therefore,
development
novel
therapeutic
strategies
accelerating
has
garnered
escalating
attention.
Covalent
organic
frameworks
(COFs)
are
an
emerging
class
crystalline
porous
polymers
constructed
through
strong
covalent
bonds.
Their
exceptional
structural
tunability
renders
them
as
ideal
platform
advanced
applications.
Herein,
two
redox‐responsive
Zn(II)‐coordinated
porphyrin
COF
hydrogels
constructed,
which
demonstrate
rapid
blood
glucose
reduction
localized
tissues,
along
with
improved
angiogenesis,
reactive
oxygen
species
(ROS)
scavenging,
photothermal
antimicrobial
capacities
within
environment
patients,
thereby
effectively
controlling
infections
concurrently
promoting
healing.
Specifically,
COFs
built‐in
dual
active
sites,
i.e.,
disulfide
or
diselenide
moieties,
can
be
cleaved
by
ROS,
releasing
Zn(II)
ions
that
possess
tissue‐repairing
properties.
Furthermore,
Zn(II)‐porphyrin
exhibits
oxidase
(GOX)‐like
activity,
catalyzing
conversion
into
non‐glucose
metabolites.
This
synergistic
combination
glucose‐responsive
release
GOX‐like
activities
restores
tissue
redox
balance
improves
microenvironment,
offering
a
promising
strategy
diagnosis
treatment
