Polymer-based antimicrobial strategies for periodontitis
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 6, 2025
Periodontitis
is
a
chronic
inflammatory
condition
driven
by
plaque-associated
microorganisms,
where
uncontrolled
bacterial
invasion
and
proliferation
impair
host
immune
responses,
leading
to
localized
periodontal
tissue
inflammation
bone
destruction.
Conventional
therapies
face
challenges,
including
incomplete
microbial
clearance
the
rise
of
antibiotic
resistance,
limiting
their
precision
effectiveness
in
managing
periodontitis.
Recently,
nanotherapies
based
on
polymeric
materials
have
introduced
advanced
approaches
antimicrobial
therapy
through
diverse
mechanisms.
This
review
explored
specific
mechanisms,
emphasizing
design
polymer-based
agents
that
employ
individual
or
synergistic
actions,
evaluated
innovations
limitations
current
strategies
while
forecasting
future
trends
development
for
Язык: Английский
Reprogram Local Electronic Configuration in Multicomponent Covalent–Organic Frameworks for Efficient Hydrogen Peroxide Photoproduction
Chemistry of Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Covalent
organic
frameworks
(COFs)
have
recently
demonstrated
significant
potential
for
photocatalysis.
Optimizing
the
local
electronic
environment
in
COFs
has
been
considered
to
be
critical
enhancing
photocatalytic
activity.
Here,
we
report
a
one-pot
"grafting-to"
strategy
reprogram
configurations
of
series
isoreticular
multicomponent
by
introducing
electron-donating
or
electron-withdrawing
groups
into
pores
transform
photoinert
photoactive
and
form
intramolecular
donor–acceptor
(D-A)
structures.
Such
D-A
structures
enhanced
overall
hydrogen
peroxide
photoproduction
facilitating
charge
carrier
separation
optimizing
band
achieve
oxygen
reduction
reaction
water
oxidation
simultaneously.
Notably,
one
incorporated
with
2-aminothiazole
exhibits
production
rate
3701
μmol
g–1
h–1
solar-to-chemical
conversion
efficiency
0.13%
without
use
any
sacrificial
reagents,
it
100%
bacterial
killing
rates
remarkable
>90%
biofilm
removal
capability.
This
COF
modification
strategy,
which
not
reported
before,
offers
unique
approach
constructing
highly
active
photocatalysts
containing
great
future
design
antibacterial
therapies.
Язык: Английский
Terpenes, natural dyes and photochemistry: toward the synthesis of photoactive bio-based materials with biocide properties
RSC Applied Polymers,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
The
thiol–ene
photochemistry
process,
combined
with
terpenes
and
natural
dyes,
yields
innovative
photostimulable
bio-based
materials
antibacterial
properties.
Язык: Английский
Biomaterials-based phototherapy for bacterial infections
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 4, 2024
Bacterial
infections
and
antibiotic
resistance
are
global
health
problems,
current
treatments
for
bacterial
still
rely
on
the
use
of
antibiotics.
Phototherapy
based
a
photosensitizer
has
high
efficiency,
broad
spectrum,
strong
selectivity,
does
not
easily
induce
drug
resistance,
is
expected
to
become
an
effective
strategy
treatment
infections,
particularly
drug-resistant
infections.
This
article
reviews
antimicrobial
strategies
phototherapy
photosensitizers,
including
photodynamic
therapy
(PDT),
photothermal
(PTT),
their
combination.
These
methods
have
significant
application
potential
in
combating
multi-drug-resistant
biofilm
providing
alternative
traditional
antibiotics
chemical
antibacterial
agents.
Язык: Английский
Hybrid Hydrogels of Polyacrylamide and Self-assembly Photodynamic Nanoparticles with Diverse Adhesion for Infected Chronic Wound Healing
Biomacromolecules,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 20, 2024
The
healing
of
infected
wounds
is
challenging
for
patients.
In
this
paper,
a
hybrid
hydrogel
with
strong
tissue
adhesion,
self-healing,
and
antibiosis
without
antibiotics
was
developed
as
dressing
to
promote
the
chronic
wounds.
Acrylamide
(PAM)
polymerized
Язык: Английский
Lignin Derivative as Visible‐Light Photo‐Initiating System for the Development of Biocide Materials under Light Irradiation
Macromolecular Rapid Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
The
design
of
a
new
visible-light
methacrylated-based
kraft
lignin
photosensitizer
(MAcL)
iodonium
salt
(Iod)
for
the
free-radical
polymerization
(FRP)
polyethylene
glycol
dimethacrylate
(PEGDMA)
under
LEDs@405,
455,
470,
505,
and
530
nm
is
reported.
As
demonstrated
by
laser
flash
photolysis
(LFP)
electron
paramagnetic
resonance
spin-trapping
(EPR
ST)
experiments,
combination
MAcL
with
an
acceptor
trimethylolpropane
tris(3-mercaptopropionate)
(TT)
used
as
crosslinker,
leads
to
formation
highly
efficient
initiating
radicals,
i.e.,
thyil
carbon-centred
promoting
thus
FRP
PEGDMA.
final
methacrylate
conversions
PEGDMA
are
very
high
range
from
80
95%
LED@530
LED@405
nm,
respectively.
For
first
time,
also
biocide
agent
it
produces
singlet
oxygen
when
exposed
visible
light.
resulting
photoinduced
bio-based
materials
incorporating
demonstrate
tremendous
antibacterial
properties
against
Staphylococcus
aureus
(S.
aureus),
inducing
100%
bacterial
death.
Язык: Английский