Lignin Derivative as Visible‐Light Photo‐Initiating System for the Development of Biocide Materials under Light Irradiation DOI Open Access
Christine Elian,

Fares Mouhoubi,

Régis Moilleron

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

The design of a new visible-light methacrylated-based kraft lignin photosensitizer (MAcL) iodonium salt (Iod) for the free-radical polymerization (FRP) polyethylene glycol dimethacrylate (PEGDMA) under LEDs@405, 455, 470, 505, and 530 nm is reported. As demonstrated by laser flash photolysis (LFP) electron paramagnetic resonance spin-trapping (EPR ST) experiments, combination MAcL with an acceptor trimethylolpropane tris(3-mercaptopropionate) (TT) used as crosslinker, leads to formation highly efficient initiating radicals, i.e., thyil carbon-centred promoting thus FRP PEGDMA. final methacrylate conversions PEGDMA are very high range from 80 95% LED@530 LED@405 nm, respectively. For first time, also biocide agent it produces singlet oxygen when exposed visible light. resulting photoinduced bio-based materials incorporating demonstrate tremendous antibacterial properties against Staphylococcus aureus (S. aureus), inducing 100% bacterial death.

Language: Английский

Biomaterials-based phototherapy for bacterial infections DOI Creative Commons

Guangzhi Wu,

Zhuo Xu, Yue Yu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 4, 2024

Bacterial infections and antibiotic resistance are global health problems, current treatments for bacterial still rely on the use of antibiotics. Phototherapy based a photosensitizer has high efficiency, broad spectrum, strong selectivity, does not easily induce drug resistance, is expected to become an effective strategy treatment infections, particularly drug-resistant infections. This article reviews antimicrobial strategies phototherapy photosensitizers, including photodynamic therapy (PDT), photothermal (PTT), their combination. These methods have significant application potential in combating multi-drug-resistant biofilm providing alternative traditional antibiotics chemical antibacterial agents.

Language: Английский

Citations

4
Polymer-based antimicrobial strategies for periodontitis DOI Creative Commons
Jiajia Chen, Shujun Dong

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Periodontitis is a chronic inflammatory condition driven by plaque-associated microorganisms, where uncontrolled bacterial invasion and proliferation impair host immune responses, leading to localized periodontal tissue inflammation bone destruction. Conventional therapies face challenges, including incomplete microbial clearance the rise of antibiotic resistance, limiting their precision effectiveness in managing periodontitis. Recently, nanotherapies based on polymeric materials have introduced advanced approaches antimicrobial therapy through diverse mechanisms. This review explored specific mechanisms, emphasizing design polymer-based agents that employ individual or synergistic actions, evaluated innovations limitations current strategies while forecasting future trends development for

Language: Английский

Citations

0
Reprogram Local Electronic Configuration in Multicomponent Covalent–Organic Frameworks for Efficient Hydrogen Peroxide Photoproduction DOI
Zhongwei Ding, Jiani Yang, Zihe Wu

et al.

Chemistry of Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Covalent organic frameworks (COFs) have recently demonstrated significant potential for photocatalysis. Optimizing the local electronic environment in COFs has been considered to be critical enhancing photocatalytic activity. Here, we report a one-pot "grafting-to" strategy reprogram configurations of series isoreticular multicomponent by introducing electron-donating or electron-withdrawing groups into pores transform photoinert photoactive and form intramolecular donor–acceptor (D-A) structures. Such D-A structures enhanced overall hydrogen peroxide photoproduction facilitating charge carrier separation optimizing band achieve oxygen reduction reaction water oxidation simultaneously. Notably, one incorporated with 2-aminothiazole exhibits production rate 3701 μmol g–1 h–1 solar-to-chemical conversion efficiency 0.13% without use any sacrificial reagents, it 100% bacterial killing rates remarkable >90% biofilm removal capability. This COF modification strategy, which not reported before, offers unique approach constructing highly active photocatalysts containing great future design antibacterial therapies.

Language: Английский

Citations

0
The Natural Anthraquinone Parietin Inactivates Candida tropicalis Biofilm by Photodynamic Mechanisms DOI Creative Commons
Juliana Marioni, Beatriz Romero, María Laura Mugas

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 548 - 548

Published: April 23, 2025

Background/Objectives: Parietin (PTN), a blue-light absorbing pigment from Teloschistes spp. lichens, exhibit photosensitizing properties via Type I (superoxide anion, O2•−) and II (singlet oxygen, 1O2) mechanisms, inactivating bacteria in vitro after photoexcitation. We evaluate the antifungal activity of PTN against Candida tropicalis biofilms under actinic irradiation, its role O2•− 1O2 production, cellular stress response. Methods: Minimum inhibitory concentration (MIC) was determined C. NCPF 3111 dark light conditions. Biofilm susceptibility assessed at MIC/2, MIC, MICx2, MICx4, MICx6 same conditions, viability measured by colony-forming units. Photodynamic mechanisms were examined using Tiron (O2•− scavenger) or sodium azide (1O2 quencher). production nitro-blue tetrazolium (NBT) reduction nitric oxide (NO) generation Griess assay. Total antioxidant capacity studied FRAP (Ferrous Reduction Antioxidant Potency) assay superoxide dismutase (SOD) NBT Results: Photoexcitation reduced biofilm four logs MICx2. Sodium partially reversed effect, whereas fully inhibited it, indicating critical O2•−. also increased NO levels, enhancing SOD FRAP. However, this response insufficient to prevent photoinactivation. Conclusions: Photoinactivation is primarily mediated O2•−, with minor contribution an imbalance levels. These findings suggest promising photosensitizer for photodynamic therapy.

Language: Английский

Citations

0
Elaborately Engineered Aggregation‐Induced Emission Antibacterial Agents: Negligible Living Cell Invasiveness, Efficient Bacterial Biofilm Inhibition and Promoting Infected Wound Healing DOI
Zu‐Sheng Huang, Zhongda Zhang, Yiting Qiu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Developing versatile photosensitizers capable of selectively eliminating pathogens over normal cells is an appealing yet highly challenging task. Herein, a novel strategy by exploiting the cationic and amphiphilic synergistic mechanism introduced to synthesize four aggregation‐induced emission (AIE)‐active antibacterial (PSs) TSPy‐CH 3 , MeO‐TSPy‐Bu MeO‐TSPy‐Va MeO‐TSPy‐CH . The PSs generated both type I II reactive oxygen species (ROS) under white light irradiation. They can quickly stain Staphylococcus aureus ( S. ) in 15 min, but exhibited different Escherichia coli E.coil affinity living cell invasiveness. caused devastating killing methicillin‐resistant (MRSA) at extremely low drug doses significantly inhibited biofilm formation drug‐resistant strains photocytotoxicity inherent dark toxicity. Their concentrations minimal invasiveness toward collectively ensured biosafety. with moderate Clog P value stands out from others virtues most reliable biosafety, broad‐spectrum bactericidal performance, excellent inhibition ability. In vivo studies on bacteria‐infected wounds confirmed that reduced inflammation, promoted angiogenesis, accelerated wound recovery, achieving comparable therapeutic outcomes vancomycin. This work provides enlightenment for designing phototherapy agents overcome key limitations such as unpredictable biosafety risk, inadequate potency, poor anti‐biofilm performance.

Language: Английский

Citations

0
Terpenes, natural dyes and photochemistry: toward the synthesis of photoactive bio-based materials with biocide properties DOI Creative Commons

Louise Breloy,

Christine Elian,

Vanessa Alphonse

et al.

RSC Applied Polymers, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

The thiol–ene photochemistry process, combined with terpenes and natural dyes, yields innovative photostimulable bio-based materials antibacterial properties.

Language: Английский

Citations

2
Hybrid Hydrogels of Polyacrylamide and Self-assembly Photodynamic Nanoparticles with Diverse Adhesion for Infected Chronic Wound Healing DOI
Tao Kang, Zhaoyuan Guo, Lu Yao

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 20, 2024

The healing of infected wounds is challenging for patients. In this paper, a hybrid hydrogel with strong tissue adhesion, self-healing, and antibiosis without antibiotics was developed as dressing to promote the chronic wounds. Acrylamide (PAM) polymerized

Language: Английский

Citations

1
Lignin Derivative as Visible‐Light Photo‐Initiating System for the Development of Biocide Materials under Light Irradiation DOI Open Access
Christine Elian,

Fares Mouhoubi,

Régis Moilleron

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

The design of a new visible-light methacrylated-based kraft lignin photosensitizer (MAcL) iodonium salt (Iod) for the free-radical polymerization (FRP) polyethylene glycol dimethacrylate (PEGDMA) under LEDs@405, 455, 470, 505, and 530 nm is reported. As demonstrated by laser flash photolysis (LFP) electron paramagnetic resonance spin-trapping (EPR ST) experiments, combination MAcL with an acceptor trimethylolpropane tris(3-mercaptopropionate) (TT) used as crosslinker, leads to formation highly efficient initiating radicals, i.e., thyil carbon-centred promoting thus FRP PEGDMA. final methacrylate conversions PEGDMA are very high range from 80 95% LED@530 LED@405 nm, respectively. For first time, also biocide agent it produces singlet oxygen when exposed visible light. resulting photoinduced bio-based materials incorporating demonstrate tremendous antibacterial properties against Staphylococcus aureus (S. aureus), inducing 100% bacterial death.

Language: Английский

Citations

0