Biomaterials-based phototherapy for bacterial infections
Guangzhi Wu,
No information about this author
Zhuo Xu,
No information about this author
Yue Yu
No information about this author
et al.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 4, 2024
Bacterial
infections
and
antibiotic
resistance
are
global
health
problems,
current
treatments
for
bacterial
still
rely
on
the
use
of
antibiotics.
Phototherapy
based
a
photosensitizer
has
high
efficiency,
broad
spectrum,
strong
selectivity,
does
not
easily
induce
drug
resistance,
is
expected
to
become
an
effective
strategy
treatment
infections,
particularly
drug-resistant
infections.
This
article
reviews
antimicrobial
strategies
phototherapy
photosensitizers,
including
photodynamic
therapy
(PDT),
photothermal
(PTT),
their
combination.
These
methods
have
significant
application
potential
in
combating
multi-drug-resistant
biofilm
providing
alternative
traditional
antibiotics
chemical
antibacterial
agents.
Language: Английский
Polymer-based antimicrobial strategies for periodontitis
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 6, 2025
Periodontitis
is
a
chronic
inflammatory
condition
driven
by
plaque-associated
microorganisms,
where
uncontrolled
bacterial
invasion
and
proliferation
impair
host
immune
responses,
leading
to
localized
periodontal
tissue
inflammation
bone
destruction.
Conventional
therapies
face
challenges,
including
incomplete
microbial
clearance
the
rise
of
antibiotic
resistance,
limiting
their
precision
effectiveness
in
managing
periodontitis.
Recently,
nanotherapies
based
on
polymeric
materials
have
introduced
advanced
approaches
antimicrobial
therapy
through
diverse
mechanisms.
This
review
explored
specific
mechanisms,
emphasizing
design
polymer-based
agents
that
employ
individual
or
synergistic
actions,
evaluated
innovations
limitations
current
strategies
while
forecasting
future
trends
development
for
Language: Английский
Reprogram Local Electronic Configuration in Multicomponent Covalent–Organic Frameworks for Efficient Hydrogen Peroxide Photoproduction
Chemistry of Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Covalent
organic
frameworks
(COFs)
have
recently
demonstrated
significant
potential
for
photocatalysis.
Optimizing
the
local
electronic
environment
in
COFs
has
been
considered
to
be
critical
enhancing
photocatalytic
activity.
Here,
we
report
a
one-pot
"grafting-to"
strategy
reprogram
configurations
of
series
isoreticular
multicomponent
by
introducing
electron-donating
or
electron-withdrawing
groups
into
pores
transform
photoinert
photoactive
and
form
intramolecular
donor–acceptor
(D-A)
structures.
Such
D-A
structures
enhanced
overall
hydrogen
peroxide
photoproduction
facilitating
charge
carrier
separation
optimizing
band
achieve
oxygen
reduction
reaction
water
oxidation
simultaneously.
Notably,
one
incorporated
with
2-aminothiazole
exhibits
production
rate
3701
μmol
g–1
h–1
solar-to-chemical
conversion
efficiency
0.13%
without
use
any
sacrificial
reagents,
it
100%
bacterial
killing
rates
remarkable
>90%
biofilm
removal
capability.
This
COF
modification
strategy,
which
not
reported
before,
offers
unique
approach
constructing
highly
active
photocatalysts
containing
great
future
design
antibacterial
therapies.
Language: Английский
The Natural Anthraquinone Parietin Inactivates Candida tropicalis Biofilm by Photodynamic Mechanisms
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(5), P. 548 - 548
Published: April 23, 2025
Background/Objectives:
Parietin
(PTN),
a
blue-light
absorbing
pigment
from
Teloschistes
spp.
lichens,
exhibit
photosensitizing
properties
via
Type
I
(superoxide
anion,
O2•−)
and
II
(singlet
oxygen,
1O2)
mechanisms,
inactivating
bacteria
in
vitro
after
photoexcitation.
We
evaluate
the
antifungal
activity
of
PTN
against
Candida
tropicalis
biofilms
under
actinic
irradiation,
its
role
O2•−
1O2
production,
cellular
stress
response.
Methods:
Minimum
inhibitory
concentration
(MIC)
was
determined
C.
NCPF
3111
dark
light
conditions.
Biofilm
susceptibility
assessed
at
MIC/2,
MIC,
MICx2,
MICx4,
MICx6
same
conditions,
viability
measured
by
colony-forming
units.
Photodynamic
mechanisms
were
examined
using
Tiron
(O2•−
scavenger)
or
sodium
azide
(1O2
quencher).
production
nitro-blue
tetrazolium
(NBT)
reduction
nitric
oxide
(NO)
generation
Griess
assay.
Total
antioxidant
capacity
studied
FRAP
(Ferrous
Reduction
Antioxidant
Potency)
assay
superoxide
dismutase
(SOD)
NBT
Results:
Photoexcitation
reduced
biofilm
four
logs
MICx2.
Sodium
partially
reversed
effect,
whereas
fully
inhibited
it,
indicating
critical
O2•−.
also
increased
NO
levels,
enhancing
SOD
FRAP.
However,
this
response
insufficient
to
prevent
photoinactivation.
Conclusions:
Photoinactivation
is
primarily
mediated
O2•−,
with
minor
contribution
an
imbalance
levels.
These
findings
suggest
promising
photosensitizer
for
photodynamic
therapy.
Language: Английский
Elaborately Engineered Aggregation‐Induced Emission Antibacterial Agents: Negligible Living Cell Invasiveness, Efficient Bacterial Biofilm Inhibition and Promoting Infected Wound Healing
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 6, 2025
Abstract
Developing
versatile
photosensitizers
capable
of
selectively
eliminating
pathogens
over
normal
cells
is
an
appealing
yet
highly
challenging
task.
Herein,
a
novel
strategy
by
exploiting
the
cationic
and
amphiphilic
synergistic
mechanism
introduced
to
synthesize
four
aggregation‐induced
emission
(AIE)‐active
antibacterial
(PSs)
TSPy‐CH
3
,
MeO‐TSPy‐Bu
MeO‐TSPy‐Va
MeO‐TSPy‐CH
.
The
PSs
generated
both
type
I
II
reactive
oxygen
species
(ROS)
under
white
light
irradiation.
They
can
quickly
stain
Staphylococcus
aureus
(
S.
)
in
15
min,
but
exhibited
different
Escherichia
coli
E.coil
affinity
living
cell
invasiveness.
caused
devastating
killing
methicillin‐resistant
(MRSA)
at
extremely
low
drug
doses
significantly
inhibited
biofilm
formation
drug‐resistant
strains
photocytotoxicity
inherent
dark
toxicity.
Their
concentrations
minimal
invasiveness
toward
collectively
ensured
biosafety.
with
moderate
Clog
P
value
stands
out
from
others
virtues
most
reliable
biosafety,
broad‐spectrum
bactericidal
performance,
excellent
inhibition
ability.
In
vivo
studies
on
bacteria‐infected
wounds
confirmed
that
reduced
inflammation,
promoted
angiogenesis,
accelerated
wound
recovery,
achieving
comparable
therapeutic
outcomes
vancomycin.
This
work
provides
enlightenment
for
designing
phototherapy
agents
overcome
key
limitations
such
as
unpredictable
biosafety
risk,
inadequate
potency,
poor
anti‐biofilm
performance.
Language: Английский
Terpenes, natural dyes and photochemistry: toward the synthesis of photoactive bio-based materials with biocide properties
Louise Breloy,
No information about this author
Christine Elian,
No information about this author
Vanessa Alphonse
No information about this author
et al.
RSC Applied Polymers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 25, 2024
The
thiol–ene
photochemistry
process,
combined
with
terpenes
and
natural
dyes,
yields
innovative
photostimulable
bio-based
materials
antibacterial
properties.
Language: Английский
Hybrid Hydrogels of Polyacrylamide and Self-assembly Photodynamic Nanoparticles with Diverse Adhesion for Infected Chronic Wound Healing
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 20, 2024
The
healing
of
infected
wounds
is
challenging
for
patients.
In
this
paper,
a
hybrid
hydrogel
with
strong
tissue
adhesion,
self-healing,
and
antibiosis
without
antibiotics
was
developed
as
dressing
to
promote
the
chronic
wounds.
Acrylamide
(PAM)
polymerized
Language: Английский
Lignin Derivative as Visible‐Light Photo‐Initiating System for the Development of Biocide Materials under Light Irradiation
Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 20, 2024
The
design
of
a
new
visible-light
methacrylated-based
kraft
lignin
photosensitizer
(MAcL)
iodonium
salt
(Iod)
for
the
free-radical
polymerization
(FRP)
polyethylene
glycol
dimethacrylate
(PEGDMA)
under
LEDs@405,
455,
470,
505,
and
530
nm
is
reported.
As
demonstrated
by
laser
flash
photolysis
(LFP)
electron
paramagnetic
resonance
spin-trapping
(EPR
ST)
experiments,
combination
MAcL
with
an
acceptor
trimethylolpropane
tris(3-mercaptopropionate)
(TT)
used
as
crosslinker,
leads
to
formation
highly
efficient
initiating
radicals,
i.e.,
thyil
carbon-centred
promoting
thus
FRP
PEGDMA.
final
methacrylate
conversions
PEGDMA
are
very
high
range
from
80
95%
LED@530
LED@405
nm,
respectively.
For
first
time,
also
biocide
agent
it
produces
singlet
oxygen
when
exposed
visible
light.
resulting
photoinduced
bio-based
materials
incorporating
demonstrate
tremendous
antibacterial
properties
against
Staphylococcus
aureus
(S.
aureus),
inducing
100%
bacterial
death.
Language: Английский