Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 495 - 523
Published: Nov. 29, 2024
Language: Английский
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 508, P. 160962 - 160962
Published: Feb. 25, 2025
Language: Английский
Citations
1
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 11, 2025
Biomolecular motors are dynamic systems found in organisms with high energy conversion efficiency. FOF1-ATPase is a rotary biomolecular motor known for its near 100% It utilizes the synthesis and hydrolysis of ATP to induce conformational changes proteins, thereby converting chemical into mechanical motion. Given their efficiency, autonomous propulsion capability, modifiable structures, have attracted significant attention potential biomedical applications. This Review aims introduce detailed structure FOF1-ATPase, explore various motility manipulation strategies, summarize applications biological detection cargo delivery. Additionally, innovative research methods proposed analyze motion mechanism more comprehensively, goal advancing Finally, this concludes key insights future perspectives.
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Abstract The balance of antibacterial and osseointegration‐promoting properties on titanium (Ti) implants in a simple efficient manner is crucial for the management implant‐associated infections, condition that has become significant global health concern. Herein, nitric oxide (NO)‐mediated dual‐function smart coating with developed Ti implants. leverages distinct NO at high low concentrations to enable an on‐demand functional switch. Specifically, function achieved through rapid release high‐dose response infection microenvironment near‐infrared stimulation. Once resolved normal physiological conditions are restored, gradually releases low‐dose promote osseointegration. In vitro tests confirm exhibits ratio 97.84% 97.18% against methicillin‐resistant Staphylococcus aureus its biofilms, respectively, demonstrates ability activate osteoblasts. rat femoral model further certifies responsive mechanism efficiently facilitates switch between properties. Notably, use dual‐functional nonantibiotic agent, NO, significantly mitigates risk bacterial resistance.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162378 - 162378
Published: April 1, 2025
Language: Английский
Citations
0
Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Acute bacterial skin and structure infections (ABSSSIs) pose significant global health challenges, exacerbated by rising antibiotic resistance. Antibacterial photodynamic therapy (APDT) has emerged as a promising strategy to combat these utilizing photosensitizer (PS) that generates reactive oxygen species (ROS) upon light activation. However, the limited tissue penetration of conventional organic PSs, which primarily absorb in UV-vis spectra, hindered their therapeutic potential for deeper infections. Herein, we introduce novel iridium(III)-cyanine complex (Ir-cy) with strong near-infrared (NIR) absorption at 814 nm (up 101 red-shifted from previous reports), specifically designed enhance APDT. Under 808 laser irradiation, Ir-cy demonstrated substantial ROS generation capacity, achieving approximately 70% reduction Staphylococcus aureus (S. aureus) colonies depth 7.2 mm within simulated model. Comprehensive vitro vivo evaluations further confirmed its potent antibacterial efficacy against S. while maintaining excellent biocompatibility. These findings highlight highly effective NIR-active PS, paving way advanced strategies targeting deep-tissue ABSSSIs through optimized
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Abstract Single‐atom catalysts (SACs) hold remarkable potential for antibacterial and multidrug‐resistant Staphylococcus aureus (MRSA) biofilm eradication, but passive diffusion often restricts their effectiveness. In contrast, microrobots can harness various energy sources highly autonomous movement. Herein, a one‐end‐opened yolk–shell microrobot with Cu single atoms anchored on carbon nitride (Y‐CuSA/CN) is designed to enhance MRSA penetration effects. The Y‐CuSA/CN achieves single‐atom‐driven propulsion by generating an H 2 O gradient via Fenton‐like reaction. Furthermore, UV‐LED light (365 nm) excitation produces photogenerated electrons, which promotes the valence cycling of single‐atom reacts , thereby further boosting microrobot's mobility catalytic activity. exhibits vigorous movement velocity 17.2 µm s −1 rate 7.2 significantly enhancing its into bacterial biofilms. During motion, reactive oxygen species (·OH, ·O − 1 ) are released oxidation. vitro in vivo experiments demonstrate that effectively eradicates biofilms wound healing infected mice. This study presents efficient strategy eradicating highlights SACs developing advanced biomedical applications.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113720 - 113720
Published: April 1, 2025
Language: Английский
Citations
0
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106626 - 106626
Published: April 1, 2025
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 526, P. 216348 - 216348
Published: Dec. 2, 2024
Language: Английский
Citations
1
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 855 - 879
Published: Dec. 7, 2024
Language: Английский
Citations
1