Immune‐Vascular Synergy: A Photodynamic Hydrogel Activating ALDH2 to Combat Inflammation and Enhance Angiogenesis in Diabetic Wound Healing DOI
Yuan Xiong, Qipeng Wu, Peng Zhang

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Abstract Infected diabetic wounds present serious therapeutic challenges, primarily due to persistent infections, impaired immune responses, and insufficient vascularization. Excessive secretion of neutrophil extracellular traps (NETs) is increasingly recognized as a key driver inflammation in wounds. Single‐cell sequencing analysis clinical specimens reveals deficiency aldehyde dehydrogenase 2 (ALDH2) within wound tissues, which plays critical role sustaining hindering vascular regeneration. Unlike conventional treatments that focus on either infection control or repair, photodynamic hydrogel with dual‐function strategy developed, uniquely integrating ALDH2 activation immune‐vascular modulation address these multifaceted challenges. The hydrogel‐mediated effectively reduces NET formation mitigates chronic inflammation, while promoting macrophage polarization from the pro‐inflammatory M1 phenotype reparative M2 phenotype. This transition fosters an anti‐inflammatory microenvironment not only facilitates tissue repair but also enhances angiogenesis by stimulating endothelial cell activity, improving vascularization at site. In contrast existing therapeutics, approach directly targets interplay between regulation regeneration, offering synergistic mechanism enhance healing outcomes. findings introduce synergy‐based strategy, emphasizing translational potential this technology for management.

Language: Английский

Skin‐Inspired and Self‐Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy DOI
Yonghang Liu, Xiaoxue Yang, Kefan Wu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Diabetic wounds are refractory and recurrent diseases that necessitate the development of multifunctional dressings. Inspired by structure function skin, we herein delicately design a novel swollen hydrophobic hydrogel (QL@MAB) composed methyl acrylate (MA) (3-acrylamidophenyl)boronic acid (AAPBA) network co-loaded with antioxidant quercetin (Q) antibiotic levofloxacin (L) for efficient diabetic wound therapy. The MA segments undergo phase separation to form dense "epidermis", ensuring prolonged drug diffusion, long-term water retention, high content. Meanwhile, AAPBA generate glucose-labile "sweat pores" via borate ester bonds polyphenol Q. Upon encountering hyperglycemic microenvironment, dilated due cleavage exposure diffusion channel, facilitating release accelerated healing. In infected rats, QL@MAB achieves rapid debridement re-epithelization while promoting angiogenesis, hair follicle regeneration, extracellular matrix remodeling. Taken together, this study not only represents multipronged dressing effective interventions but also contributes rational smart hydrogels tailored biomedical applications.

Language: Английский

Citations

3
pH-responsive and self-adaptive injectable sodium alginate/carboxymethyl chitosan hydrogel accelerates infected wound healing by bacteriostasis and immunomodulation DOI
Xi Zhang,

Yongzhe Liu,

Ziwei Wang

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123322 - 123322

Published: Jan. 1, 2025

Language: Английский

Citations

1
Enhanced Osteogenic Differentiation of hMSCs Using BMP@ZIF-8-Loaded GelMA Nanocomposite Hydrogels with Controlled BMP-2 Release DOI Creative Commons
Weihao Yuan, Luiza de Almeida Queiroz Ferreira,

Ronit Khade

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Hydrogels are highly versatile materials with immense potential for tissue engineering and regenerative medicine owing to their biocompatibility, tunable mechanical properties, ability mimic the natural extracellular matrix. Their 3D porous structure allows encapsulation delivery of bioactive molecules, making them ideal candidates drug systems. In repair, particularly bone regeneration, hydrogels can serve as carriers that release therapeutic agents in a controlled manner, thus enhancing healing process. Zeolitic Imidazolate Framework-8 (ZIF-8) nanoparticles recombinant human Bone Morphogenetic Protein (rhBMP-2) molecules were incorporated solely (ZIF@GelMA) or association (BMP@ZIF@GelMA) into gelatin modified by methacryloyl hydrogel (GelMA) investigate its physical osteogenic properties. characterized Scanning Electron Microscopy rheological tests. We analyzed degradation BSA profile BMP@ZIF@GelMA samples throughout 0, 1, 3, 7, 14, 28 days. Cell adhesion formation markers hydrogel-encapsulated dental pulp cells using immunocytochemistry molecular analysis. ZIF@GelMA exhibited viscoelastic increased storage modulus when rhBMP2 was present. BSA@ZIF@GelMA showed balanced rate BSA. The upregulated expression cell genes, BMP-2 introduced, levels remarkably elevated. presents several favorable factors promote cellular encouraging further prospects advanced applications repair.

Language: Английский

Citations

1
Multifunctional, NIR light-responsive, 4D printable polyurethane/polydopamine nanocomposite DOI
Jiahuan Wang,

Yuanyang Xu,

Dongfei Zhang

et al.

Polymer, Journal Year: 2025, Volume and Issue: unknown, P. 128214 - 128214

Published: Feb. 1, 2025

Language: Английский

Citations

0
Adhesive and Antioxidant Hydrogel with Glucose/ROS Dual-Responsive Drug Release for Diabetic Oral Mucosal Wound Healing DOI

Yi Yu,

Mingjin Zhang, Jing Li

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Diabetes mellitus is a global health threat, with chronic wounds, including oral mucosal being severe complication. These wounds are characterized by delayed healing and increased inflammation due to hyperglycemia, affecting patients' quality of life. Current treatments for cannot offer sustained management these injuries in diabetic patients. Here, glucose/ROS dual-responsive hydrogel incorporating sitagliptin was developed the treatment wounds. After chemical modification tetra-armed poly(ethylene glycol) succinimidyl glutarate (tetra-PEG-SG) dopamine (DA) amine (tetra-PEG-NH2) phenylboronic acid (PBA), resulting capable rapid gelation, robust tissue adhesion, self-healing, antioxidant capacity, dual response glucose reactive oxygen species (ROS), enabling feasible injection stable adherence moist environment while ensuring therapeutic release. In vivo experiments on defects mice revealed that sitagliptin-loaded could effectively reduce promote wound healing. Collectively, this finding identifies potential dressing as strategy

Language: Английский

Citations

0
Advancements and Prospects of pH-Responsive Hydrogels in Biomedicine DOI Creative Commons

Ke Gao,

Ke Xu

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 293 - 293

Published: April 15, 2025

As an intelligent polymer material, pH-sensitive hydrogels exhibit the capability to dynamically sense alterations in ambient pH levels and subsequently initiate corresponding physical or chemical responses, including swelling, contraction, degradation, ion exchange. Given significant variations inherent human pathophysiological microenvironments, particularly tumor tissues, inflammatory lesions, gastrointestinal system, these smart materials demonstrate remarkable application potential across diverse domains such as targeted drug delivery systems, regenerative medicine engineering, biosensing, disease diagnostics. Recent breakthroughs nanotechnology precision have substantially propelled advancements design of pH-responsive hydrogels. This review systematically elaborates on current research progress future challenges regarding biomedical applications, with particular emphasis their stimulus–response mechanisms, fabrication methodologies, multifunctional integration strategies, scenarios.

Language: Английский

Citations

0
Tailoring of a specific pH-induced self-enhanced photothermal cellulose hydrogel for antibiotic-resistant bacteria-infected wound treatment DOI
Rimei Chen, Yonghui He,

Lingli Tian

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 513, P. 163025 - 163025

Published: April 23, 2025

Language: Английский

Citations

0
Stimulus-Responsive Hydrogels for Diabetic Wound Management via Microenvironment Modulation DOI
Yang Gao, Xinxin Chen, Chaoliang He

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Diabetic wounds, a major complication of diabetes mellitus, pose significant clinical challenge. The treatment diabetic wounds requires comprehensive interventions tailored to their pathophysiological characteristics, such as recurring bacterial infection, persistent inflammation, excessive oxidative stress, and impaired angiogenesis. development stimulus-responsive hydrogel dressings offers new strategies for wound treatment. By responding various physical biochemical signals, these smart hydrogels enable real-time monitoring precise modulation the microenvironment accelerate healing. In this review, we provide an overview disease characteristics chronic introduce current approaches. We summarize cutting-edge applications signal-responsive by modulating microenvironment.

Language: Английский

Citations

0
Pt-Induced Sublattice Distortion Facilitates Enzyme Cascade Reactions for Eradicating Intracellularly Methicillin-Resistant Staphylococcus aureus and Enhancing Diabetic Wound Healing DOI

Xiaoning Hou,

Hongsu Wang, Xinyu Yao

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Metal oxide nanozymes hold significant potential in combating bacterial infections; however, their ordered crystal structures limit the enhancement of catalytic activity, posing challenges addressing clinical needs for eliminating intracellularly colonized bacteria. Here, we report development an integrated diagnostic-therapeutic microneedle patch incorporates Res@PtZ-Z nanozyme hybrid. consists a ZIF shell loaded with natural compound resveratrol (Res), encapsulating Pt-doped zinc (ZnO) core (PtZ). The Res component modulates charge distribution on and attenuates virulence, thereby promoting uptake by host cells. PtZ core, doped Pt4+ to induce sublattice distortion ZnO, exhibits oxidase-like, peroxidase-like, catalase-like activities. Under intracellular hypoxic conditions, cascade these enzyme-like activities ensures sustained generation reactive oxygen species (ROS), enabling robust antibacterial effects. Additionally, enables real-time infection monitoring oxidizing 3,3',5,5'-tetramethylbenzidine (TMB) substrate produce distinct colorimetric response. This approach addresses both methicillin-resistant Staphylococcus aureus (MRSA) invasion persistence, contributing improved management wound healing.

Language: Английский

Citations

0
Immune‐Vascular Synergy: A Photodynamic Hydrogel Activating ALDH2 to Combat Inflammation and Enhance Angiogenesis in Diabetic Wound Healing DOI
Yuan Xiong, Qipeng Wu, Peng Zhang

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Abstract Infected diabetic wounds present serious therapeutic challenges, primarily due to persistent infections, impaired immune responses, and insufficient vascularization. Excessive secretion of neutrophil extracellular traps (NETs) is increasingly recognized as a key driver inflammation in wounds. Single‐cell sequencing analysis clinical specimens reveals deficiency aldehyde dehydrogenase 2 (ALDH2) within wound tissues, which plays critical role sustaining hindering vascular regeneration. Unlike conventional treatments that focus on either infection control or repair, photodynamic hydrogel with dual‐function strategy developed, uniquely integrating ALDH2 activation immune‐vascular modulation address these multifaceted challenges. The hydrogel‐mediated effectively reduces NET formation mitigates chronic inflammation, while promoting macrophage polarization from the pro‐inflammatory M1 phenotype reparative M2 phenotype. This transition fosters an anti‐inflammatory microenvironment not only facilitates tissue repair but also enhances angiogenesis by stimulating endothelial cell activity, improving vascularization at site. In contrast existing therapeutics, approach directly targets interplay between regulation regeneration, offering synergistic mechanism enhance healing outcomes. findings introduce synergy‐based strategy, emphasizing translational potential this technology for management.

Language: Английский

Citations

0