Mg bone implant: Features, developments and perspectives

Materials & Design, Год журнала: 2019, Номер 185, С. 108259 - 108259

Опубликована: Окт. 11, 2019

Mg and its alloys have been identified as promising bone implant materials owing to their natural degradability, good biocompatibility favorable mechanical properties. Nevertheless, the too fast degradation rate usually results in a premature disintegration of integrity local hydrogen accumulation, which limit clinical repair application. In this work, current research status regarding implants was systematically reviewed. The relevant strategies enhance corrosion resistance, including purification, alloying treatment, surface coating Mg-based metal matrix composite, are comprehensively discussed. fabricating techniques for also presented. Particularly, laser additive manufacturing can fabricate customized shape complex porous structure basing on unique concept. More importantly, it achieve rapid heating cooling due characteristics high energy density controllability, thereby regulating microstructure performance. Furthermore, challenges future perspectives put forward. This work aims offer some meaningful guidelines researchers study implants.

Язык: Английский

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Scaffolds for bone-tissue engineering

Matter, Год журнала: 2022, Номер 5(9), С. 2722 - 2759

Опубликована: Сен. 1, 2022

Язык: Английский

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Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Advanced Healthcare Materials, Год журнала: 2021, Номер 10(14)

Опубликована: Май 5, 2021

Abstract The failure to repair critical‐sized bone defects often leads incomplete regeneration or fracture non‐union. Tissue‐engineered grafts have been recognized as an alternative strategy for due their potential defects. To design a successful tissue‐engineered graft requires the understanding of physicochemical optimization mimic composition and structure native bone, well biological strategies mimicking key elements during process. This review provides overview engineered graft‐based focusing on properties materials from macroscale nanoscale further boost regeneration, it summarizes which mainly focus growth factors following pattern stem cell‐based more efficient repair. Finally, discusses current limitations existing upon highlights promising rapid regeneration.

Язык: Английский

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Biomaterial–Related Cell Microenvironment in Tissue Engineering and Regenerative Medicine

Engineering, Год журнала: 2022, Номер 13, С. 31 - 45

Опубликована: Март 17, 2022

An appropriate cell microenvironment is key to tissue engineering and regenerative medicine. Revealing the factors that influence a fundamental research topic in fields of biology, biomaterials, engineering, The consists not only its surrounding cells soluble factors, but also extracellular matrix (ECM) or nearby external biomaterials regeneration. This review focuses on six aspects biomaterial–related microenvironments: ① chemical composition materials, ② material dimensions architecture, ③ material–controlled geometry, ④ effects charges cells, ⑤ stiffness biomechanical microenvironment, ⑥ surface modification materials. present challenges are mentioned, eight perspectives predicted.

Язык: Английский

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Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and Angiogenesis In Vitro

Tissue Engineering and Regenerative Medicine, Год журнала: 2019, Номер 16(4), С. 415 - 429

Опубликована: Июнь 17, 2019

Язык: Английский

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Reconsidering Osteoconduction in the Era of Additive Manufacturing

Tissue Engineering Part B Reviews, Год журнала: 2019, Номер 25(5), С. 375 - 386

Опубликована: Апрель 18, 2019

Bone regeneration procedures in clinics and bone tissue engineering stand on three pillars: osteoconduction, osteoinduction, stem cells. In the last two decades, focus this field has been which is realized by use of morphogenetic proteins application mesenchymal cells to treat defects. However, osteoconduction was reduced a surface phenomenon because supposedly ideal pore size osteoconductive scaffolds identified 1990s as 0.3-0.5 mm diameter, forcing formation occur predominantly surface. Meanwhile, additive manufacturing evolved new tool realize designed microarchitectures substitutes, thereby enabling us study true three-dimensional phenomenon. Moreover, manufacturing, wide-open porous can be produced occurs distant at superior bony defect-bridging rate enabled highly pores 1.2 diameter. This review provides historical overview an updated definition related terms. addition, it shows how instrumental studying optimizing novel optimized features boundaries microarchitectures. Impact Statement updates draws clear lines discriminate between osseointegration, osteoinduction. additively manufactured libraries revealed that: more than phenomenon; microarchitecture dictates defect bridging, measure for osteoconduction; diameter or diagonal lattice substitutes should ∼1.2 mm.

Язык: Английский

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Sol–gel synthesis of calcium phosphate-based biomaterials—A review of environmentally benign, simple, and effective synthesis routes

Journal of Sol-Gel Science and Technology, Год журнала: 2020, Номер 94(3), С. 551 - 572

Опубликована: Фев. 14, 2020

Язык: Английский

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Construction of nanofibrous scaffolds with interconnected perfusable microchannel networks for engineering of vascularized bone tissue

Bioactive Materials, Год журнала: 2021, Номер 6(10), С. 3254 - 3268

Опубликована: Март 14, 2021

Vascularization and bone regeneration are two closely related processes during reconstruction. A three-dimensional (3D) scaffold with porous architecture provides a suitable microenvironment for vascular growth formation. Here, we present simple general strategy to construct nanofibrous poly(l-lactide)/poly(ε-caprolactone) (PLLA/PCL) interconnected perfusable microchannel networks (IPMs) based on 3D printing technology by combining the phase separation sacrificial template methods. The regular customizable patterns within scaffolds (spacings: 0.4 mm, 0.5 0.6 mm; diameters: 0.8 1 1.2 mm) were made investigate effect of structure angiogenesis osteogenesis. results subcutaneous embedding experiment showed that 0.5/0.8-IPMs (spacing/diameter = 0.5/0.8) 0.5/1-IPMs 0.5/1) exhibited more network formation as compared other counterparts. After loading endothelial factor (VEGF), [email protected]/0.8 prompted better human umbilical vein cells (HUVECs) migration neo-blood vessel formation, determined Transwell migration, scratch wound healing, chorioallantoic membrane (CAM) assays. Furthermore, microangiography rat cranial defects experiments demonstrated performance in new protected]/1 scaffold. In summary, our suggested could be tailored an adjustable caramel-based strategy, combination perfusion angiogenic factors significantly enhance vascularization regeneration.

Язык: Английский

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Construction and application of textile-based tissue engineering scaffolds: a review

Biomaterials Science, Год журнала: 2020, Номер 8(13), С. 3574 - 3600

Опубликована: Янв. 1, 2020

This review discussed the structure–function relationship of textile-based scaffolds and appropriate textile technologies for application in certain kinds tissue scaffolds.

Язык: Английский

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Bone Scaffolds: An Incorporation of Biomaterials, Cells, and Biofactors

ACS Biomaterials Science & Engineering, Год журнала: 2021, Номер 7(12), С. 5397 - 5431

Опубликована: Ноя. 19, 2021

Large injuries to bones are still one of the most challenging musculoskeletal problems. Tissue engineering can combine stem cells, scaffold biomaterials, and biofactors aid in resolving this complication. Therefore, review aims provide information on recent advances made utilize potential biomaterials for making bone scaffolds assisted cell therapy use tissue engineering. The requirements different types used reviewed. Furthermore, importance cells (growth factors extracellular vesicles) regeneration their key findings discussed. Lastly, some main obstacles future trends highlighted.

Язык: Английский

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