Clinical and Translational Medicine,
Journal Year:
2022,
Volume and Issue:
12(2)
Published: Feb. 1, 2022
Bone
tissue
engineering
is
a
rapidly
developing
field
with
potential
for
the
regeneration
of
craniomaxillofacial
(CMF)
bones,
3D
printing
being
suitable
fabrication
tool
patient-specific
implants.
The
CMF
region
includes
variety
different
bones
distinct
functions.
clinical
implementation
concepts
currently
poor,
likely
due
to
multiple
reasons
including
complexity
anatomy
and
biology,
limited
relevance
used
preclinical
models.
'recapitulation
human
disease'
core
requisite
animal
models,
but
this
aspect
often
neglected,
vast
majority
studies
failing
identify
specific
indication
they
are
targeting
and/or
rationale
choosing
one
model
over
another.
Currently,
there
no
guidelines
that
propose
most
appropriate
address
pathology
standards
established
test
efficacy
biomaterials
or
engineered
constructs
in
field.
This
review
reports
current
scenario
reconstruction,
then
discusses
numerous
limitations
models
employed
validating
3D-printed
need
reduce
work
does
not
question.
We
will
highlight
critical
research
aspects
consider,
pave
clinically
driven
path
development
new
materials
reconstruction.
Materials & Design,
Journal Year:
2019,
Volume and Issue:
185, P. 108259 - 108259
Published: Oct. 11, 2019
Mg
and
its
alloys
have
been
identified
as
promising
bone
implant
materials
owing
to
their
natural
degradability,
good
biocompatibility
favorable
mechanical
properties.
Nevertheless,
the
too
fast
degradation
rate
usually
results
in
a
premature
disintegration
of
integrity
local
hydrogen
accumulation,
which
limit
clinical
repair
application.
In
this
work,
current
research
status
regarding
implants
was
systematically
reviewed.
The
relevant
strategies
enhance
corrosion
resistance,
including
purification,
alloying
treatment,
surface
coating
Mg-based
metal
matrix
composite,
are
comprehensively
discussed.
fabricating
techniques
for
also
presented.
Particularly,
laser
additive
manufacturing
can
fabricate
customized
shape
complex
porous
structure
basing
on
unique
concept.
More
importantly,
it
achieve
rapid
heating
cooling
due
characteristics
high
energy
density
controllability,
thereby
regulating
microstructure
performance.
Furthermore,
challenges
future
perspectives
put
forward.
This
work
aims
offer
some
meaningful
guidelines
researchers
study
implants.
Advanced Healthcare Materials,
Journal Year:
2021,
Volume and Issue:
10(14)
Published: May 5, 2021
Abstract
The
failure
to
repair
critical‐sized
bone
defects
often
leads
incomplete
regeneration
or
fracture
non‐union.
Tissue‐engineered
grafts
have
been
recognized
as
an
alternative
strategy
for
due
their
potential
defects.
To
design
a
successful
tissue‐engineered
graft
requires
the
understanding
of
physicochemical
optimization
mimic
composition
and
structure
native
bone,
well
biological
strategies
mimicking
key
elements
during
process.
This
review
provides
overview
engineered
graft‐based
focusing
on
properties
materials
from
macroscale
nanoscale
further
boost
regeneration,
it
summarizes
which
mainly
focus
growth
factors
following
pattern
stem
cell‐based
more
efficient
repair.
Finally,
discusses
current
limitations
existing
upon
highlights
promising
rapid
regeneration.
Engineering,
Journal Year:
2022,
Volume and Issue:
13, P. 31 - 45
Published: March 17, 2022
An
appropriate
cell
microenvironment
is
key
to
tissue
engineering
and
regenerative
medicine.
Revealing
the
factors
that
influence
a
fundamental
research
topic
in
fields
of
biology,
biomaterials,
engineering,
The
consists
not
only
its
surrounding
cells
soluble
factors,
but
also
extracellular
matrix
(ECM)
or
nearby
external
biomaterials
regeneration.
This
review
focuses
on
six
aspects
biomaterial–related
microenvironments:
①
chemical
composition
materials,
②
material
dimensions
architecture,
③
material–controlled
geometry,
④
effects
charges
cells,
⑤
stiffness
biomechanical
microenvironment,
⑥
surface
modification
materials.
present
challenges
are
mentioned,
eight
perspectives
predicted.
Tissue Engineering Part B Reviews,
Journal Year:
2019,
Volume and Issue:
25(5), P. 375 - 386
Published: April 18, 2019
Bone
regeneration
procedures
in
clinics
and
bone
tissue
engineering
stand
on
three
pillars:
osteoconduction,
osteoinduction,
stem
cells.
In
the
last
two
decades,
focus
this
field
has
been
which
is
realized
by
use
of
morphogenetic
proteins
application
mesenchymal
cells
to
treat
defects.
However,
osteoconduction
was
reduced
a
surface
phenomenon
because
supposedly
ideal
pore
size
osteoconductive
scaffolds
identified
1990s
as
0.3-0.5
mm
diameter,
forcing
formation
occur
predominantly
surface.
Meanwhile,
additive
manufacturing
evolved
new
tool
realize
designed
microarchitectures
substitutes,
thereby
enabling
us
study
true
three-dimensional
phenomenon.
Moreover,
manufacturing,
wide-open
porous
can
be
produced
occurs
distant
at
superior
bony
defect-bridging
rate
enabled
highly
pores
1.2
diameter.
This
review
provides
historical
overview
an
updated
definition
related
terms.
addition,
it
shows
how
instrumental
studying
optimizing
novel
optimized
features
boundaries
microarchitectures.
Impact
Statement
updates
draws
clear
lines
discriminate
between
osseointegration,
osteoinduction.
additively
manufactured
libraries
revealed
that:
more
than
phenomenon;
microarchitecture
dictates
defect
bridging,
measure
for
osteoconduction;
diameter
or
diagonal
lattice
substitutes
should
∼1.2
mm.
Bioactive Materials,
Journal Year:
2021,
Volume and Issue:
6(10), P. 3254 - 3268
Published: March 14, 2021
Vascularization
and
bone
regeneration
are
two
closely
related
processes
during
reconstruction.
A
three-dimensional
(3D)
scaffold
with
porous
architecture
provides
a
suitable
microenvironment
for
vascular
growth
formation.
Here,
we
present
simple
general
strategy
to
construct
nanofibrous
poly(l-lactide)/poly(ε-caprolactone)
(PLLA/PCL)
interconnected
perfusable
microchannel
networks
(IPMs)
based
on
3D
printing
technology
by
combining
the
phase
separation
sacrificial
template
methods.
The
regular
customizable
patterns
within
scaffolds
(spacings:
0.4
mm,
0.5
0.6
mm;
diameters:
0.8
1
1.2
mm)
were
made
investigate
effect
of
structure
angiogenesis
osteogenesis.
results
subcutaneous
embedding
experiment
showed
that
0.5/0.8-IPMs
(spacing/diameter
=
0.5/0.8)
0.5/1-IPMs
0.5/1)
exhibited
more
network
formation
as
compared
other
counterparts.
After
loading
endothelial
factor
(VEGF),
[email
protected]/0.8
prompted
better
human
umbilical
vein
cells
(HUVECs)
migration
neo-blood
vessel
formation,
determined
Transwell
migration,
scratch
wound
healing,
chorioallantoic
membrane
(CAM)
assays.
Furthermore,
microangiography
rat
cranial
defects
experiments
demonstrated
performance
in
new
protected]/1
scaffold.
In
summary,
our
suggested
could
be
tailored
an
adjustable
caramel-based
strategy,
combination
perfusion
angiogenic
factors
significantly
enhance
vascularization
regeneration.
Biomaterials Science,
Journal Year:
2020,
Volume and Issue:
8(13), P. 3574 - 3600
Published: Jan. 1, 2020
This
review
discussed
the
structure–function
relationship
of
textile-based
scaffolds
and
appropriate
textile
technologies
for
application
in
certain
kinds
tissue
scaffolds.
ACS Biomaterials Science & Engineering,
Journal Year:
2021,
Volume and Issue:
7(12), P. 5397 - 5431
Published: Nov. 19, 2021
Large
injuries
to
bones
are
still
one
of
the
most
challenging
musculoskeletal
problems.
Tissue
engineering
can
combine
stem
cells,
scaffold
biomaterials,
and
biofactors
aid
in
resolving
this
complication.
Therefore,
review
aims
provide
information
on
recent
advances
made
utilize
potential
biomaterials
for
making
bone
scaffolds
assisted
cell
therapy
use
tissue
engineering.
The
requirements
different
types
used
reviewed.
Furthermore,
importance
cells
(growth
factors
extracellular
vesicles)
regeneration
their
key
findings
discussed.
Lastly,
some
main
obstacles
future
trends
highlighted.
