Clinically relevant preclinical animal models for testing novel cranio‐maxillofacial bone 3D‐printed biomaterials DOI Creative Commons
Luan Phelipe Hatt, Keith Thompson, Jill A. Helms

et al.

Clinical and Translational Medicine, Journal Year: 2022, Volume and Issue: 12(2)

Published: Feb. 1, 2022

Bone tissue engineering is a rapidly developing field with potential for the regeneration of craniomaxillofacial (CMF) bones, 3D printing being suitable fabrication tool patient-specific implants. The CMF region includes variety different bones distinct functions. clinical implementation concepts currently poor, likely due to multiple reasons including complexity anatomy and biology, limited relevance used preclinical models. 'recapitulation human disease' core requisite animal models, but this aspect often neglected, vast majority studies failing identify specific indication they are targeting and/or rationale choosing one model over another. Currently, there no guidelines that propose most appropriate address pathology standards established test efficacy biomaterials or engineered constructs in field. This review reports current scenario reconstruction, then discusses numerous limitations models employed validating 3D-printed need reduce work does not question. We will highlight critical research aspects consider, pave clinically driven path development new materials reconstruction.

Language: Английский

Mg bone implant: Features, developments and perspectives DOI Creative Commons
Youwen Yang,

Chongxian He,

E Dianyu

et al.

Materials & Design, Journal Year: 2019, Volume and Issue: 185, P. 108259 - 108259

Published: Oct. 11, 2019

Mg and its alloys have been identified as promising bone implant materials owing to their natural degradability, good biocompatibility favorable mechanical properties. Nevertheless, the too fast degradation rate usually results in a premature disintegration of integrity local hydrogen accumulation, which limit clinical repair application. In this work, current research status regarding implants was systematically reviewed. The relevant strategies enhance corrosion resistance, including purification, alloying treatment, surface coating Mg-based metal matrix composite, are comprehensively discussed. fabricating techniques for also presented. Particularly, laser additive manufacturing can fabricate customized shape complex porous structure basing on unique concept. More importantly, it achieve rapid heating cooling due characteristics high energy density controllability, thereby regulating microstructure performance. Furthermore, challenges future perspectives put forward. This work aims offer some meaningful guidelines researchers study implants.

Language: Английский

Citations

372

Scaffolds for bone-tissue engineering DOI Creative Commons
Seunghun S. Lee, Xiaoyu Du, Inseon Kim

et al.

Matter, Journal Year: 2022, Volume and Issue: 5(9), P. 2722 - 2759

Published: Sept. 1, 2022

Language: Английский

Citations

150

Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration DOI

Chang Xie,

Jinchun Ye,

Renjie Liang

et al.

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 10(14)

Published: May 5, 2021

Abstract The failure to repair critical‐sized bone defects often leads incomplete regeneration or fracture non‐union. Tissue‐engineered grafts have been recognized as an alternative strategy for due their potential defects. To design a successful tissue‐engineered graft requires the understanding of physicochemical optimization mimic composition and structure native bone, well biological strategies mimicking key elements during process. This review provides overview engineered graft‐based focusing on properties materials from macroscale nanoscale further boost regeneration, it summarizes which mainly focus growth factors following pattern stem cell‐based more efficient repair. Finally, discusses current limitations existing upon highlights promising rapid regeneration.

Language: Английский

Citations

131

Biomaterial–Related Cell Microenvironment in Tissue Engineering and Regenerative Medicine DOI Creative Commons
Jingming Gao,

Xiaoye Yu,

Xinlei Wang

et al.

Engineering, Journal Year: 2022, Volume and Issue: 13, P. 31 - 45

Published: March 17, 2022

An appropriate cell microenvironment is key to tissue engineering and regenerative medicine. Revealing the factors that influence a fundamental research topic in fields of biology, biomaterials, engineering, The consists not only its surrounding cells soluble factors, but also extracellular matrix (ECM) or nearby external biomaterials regeneration. This review focuses on six aspects biomaterial–related microenvironments: ① chemical composition materials, ② material dimensions architecture, ③ material–controlled geometry, ④ effects charges cells, ⑤ stiffness biomechanical microenvironment, ⑥ surface modification materials. present challenges are mentioned, eight perspectives predicted.

Language: Английский

Citations

87

Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and Angiogenesis In Vitro DOI
Yifan Gu, Jing Zhang, Xinzhi Zhang

et al.

Tissue Engineering and Regenerative Medicine, Journal Year: 2019, Volume and Issue: 16(4), P. 415 - 429

Published: June 17, 2019

Language: Английский

Citations

135

Reconsidering Osteoconduction in the Era of Additive Manufacturing DOI
Franz E. Weber

Tissue Engineering Part B Reviews, Journal Year: 2019, Volume and Issue: 25(5), P. 375 - 386

Published: April 18, 2019

Bone regeneration procedures in clinics and bone tissue engineering stand on three pillars: osteoconduction, osteoinduction, stem cells. In the last two decades, focus this field has been which is realized by use of morphogenetic proteins application mesenchymal cells to treat defects. However, osteoconduction was reduced a surface phenomenon because supposedly ideal pore size osteoconductive scaffolds identified 1990s as 0.3-0.5 mm diameter, forcing formation occur predominantly surface. Meanwhile, additive manufacturing evolved new tool realize designed microarchitectures substitutes, thereby enabling us study true three-dimensional phenomenon. Moreover, manufacturing, wide-open porous can be produced occurs distant at superior bony defect-bridging rate enabled highly pores 1.2 diameter. This review provides historical overview an updated definition related terms. addition, it shows how instrumental studying optimizing novel optimized features boundaries microarchitectures. Impact Statement updates draws clear lines discriminate between osseointegration, osteoinduction. additively manufactured libraries revealed that: more than phenomenon; microarchitecture dictates defect bridging, measure for osteoconduction; diameter or diagonal lattice substitutes should ∼1.2 mm.

Language: Английский

Citations

86

Construction of nanofibrous scaffolds with interconnected perfusable microchannel networks for engineering of vascularized bone tissue DOI Creative Commons

Jiani Gu,

Qianqian Zhang,

Mengru Geng

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(10), P. 3254 - 3268

Published: March 14, 2021

Vascularization and bone regeneration are two closely related processes during reconstruction. A three-dimensional (3D) scaffold with porous architecture provides a suitable microenvironment for vascular growth formation. Here, we present simple general strategy to construct nanofibrous poly(l-lactide)/poly(ε-caprolactone) (PLLA/PCL) interconnected perfusable microchannel networks (IPMs) based on 3D printing technology by combining the phase separation sacrificial template methods. The regular customizable patterns within scaffolds (spacings: 0.4 mm, 0.5 0.6 mm; diameters: 0.8 1 1.2 mm) were made investigate effect of structure angiogenesis osteogenesis. results subcutaneous embedding experiment showed that 0.5/0.8-IPMs (spacing/diameter = 0.5/0.8) 0.5/1-IPMs 0.5/1) exhibited more network formation as compared other counterparts. After loading endothelial factor (VEGF), [email protected]/0.8 prompted better human umbilical vein cells (HUVECs) migration neo-blood vessel formation, determined Transwell migration, scratch wound healing, chorioallantoic membrane (CAM) assays. Furthermore, microangiography rat cranial defects experiments demonstrated performance in new protected]/1 scaffold. In summary, our suggested could be tailored an adjustable caramel-based strategy, combination perfusion angiogenic factors significantly enhance vascularization regeneration.

Language: Английский

Citations

77

Sol–gel synthesis of calcium phosphate-based biomaterials—A review of environmentally benign, simple, and effective synthesis routes DOI
Kunio Ishikawa,

Edita Garškaité,

Aivaras Kareiva

et al.

Journal of Sol-Gel Science and Technology, Journal Year: 2020, Volume and Issue: 94(3), P. 551 - 572

Published: Feb. 14, 2020

Language: Английский

Citations

76

Construction and application of textile-based tissue engineering scaffolds: a review DOI

Yongjie Jiao,

Chaojing Li, Laijun Liu

et al.

Biomaterials Science, Journal Year: 2020, Volume and Issue: 8(13), P. 3574 - 3600

Published: Jan. 1, 2020

This review discussed the structure–function relationship of textile-based scaffolds and appropriate textile technologies for application in certain kinds tissue scaffolds.

Language: Английский

Citations

74

Bone Scaffolds: An Incorporation of Biomaterials, Cells, and Biofactors DOI

Marjan Bahraminasab,

Mahsa Janmohammadi,

Samaneh Arab

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2021, Volume and Issue: 7(12), P. 5397 - 5431

Published: Nov. 19, 2021

Large injuries to bones are still one of the most challenging musculoskeletal problems. Tissue engineering can combine stem cells, scaffold biomaterials, and biofactors aid in resolving this complication. Therefore, review aims provide information on recent advances made utilize potential biomaterials for making bone scaffolds assisted cell therapy use tissue engineering. The requirements different types used reviewed. Furthermore, importance cells (growth factors extracellular vesicles) regeneration their key findings discussed. Lastly, some main obstacles future trends highlighted.

Language: Английский

Citations

69