ACS Nano,
Год журнала:
2020,
Номер
14(4), С. 5121 - 5134
Опубликована: Апрель 13, 2020
Supramolecular
nanomaterials
as
drug
carriers
have
recently
received
increasing
attention
due
to
their
intrinsic
merits
such
high
stability,
strong
inclusion
capability,
and
facile
modification
of
the
parental
structure;
however,
intelligent
ones
with
combined
capacities
long
blood
circulation,
highly
efficient
tumor
cell
uptake,
site-oriented
release
inside
cells
are
still
rather
limited.
Herein,
we
report
a
strategy
using
supramolecular
aggregation-induced
emission
(AIE)
nanodots
for
image-guided
delivery,
which
integrate
both
advantages
AIE
nanomaterials.
The
dots
prepared
by
host-guest
coassembly
matrix
metalloproteinase-2
(MMP-2)
sensitive
PEG-peptide
(PEG2000-RRRRRRRR
(R8)-PLGLAG-EKEKEKEKEKEK
(EK6))
functional
α-cyclodextrins
(α-CD)
derivatives
that
conjugated
anticancer
gemcitabine
(GEM)
far-red/near-infrared
fluorescent
rhodanine-3-acetic
acid-based
luminogen,
respectively.
realize
circulation
time
virtue
zwitterionic
stealth
peptide
EK6.
After
largely
accumulating
in
tissues
enhanced
permeability
retention
effect,
can
successively
respond
tumor-overexpressed
MMP-2
intracellular
reductive
microenvironment,
achieving
cancer
cellular
uptake
selective
GEM
within
cells,
thus
exhibit
excellent
inhibition
ability
subcutaneous
orthotopic
pancreatic
models.
ACS Nano,
Год журнала:
2019,
Номер
13(10), С. 11283 - 11293
Опубликована: Сен. 17, 2019
Efficient
organic
photosensitizers
(PSs)
have
attracted
much
attention
because
of
their
promising
applications
in
photodynamic
therapy
(PDT).
However,
guidelines
on
molecular
design
are
rarely
reported.
In
this
work,
a
series
PSs
designed
and
synthesized
based
triphenylamine-azafluorenone
core.
Their
structure-property-application
relationships
systematically
studied.
Cationization
is
an
effective
strategy
to
enhance
the
PDT
efficiency
by
targeting
mitochondria.
From
molecularly
dispersed
state
aggregate
state,
fluorescence
reactive
oxygen
species
generation
with
aggregation-induced
emission
(AIE)
increase
due
restriction
intramolecular
motions
enhancement
intersystem
crossing.
Cationized
mitochondrion-targeting
show
higher
than
that
nonionized
ones
lipid
droplets.
The
ability
AIE
kill
cancer
cells
can
be
further
enhanced
combination
radiotherapy.
Such
results
should
trigger
research
enthusiasm
for
designing
synthesizing
better
properties.
Advanced Materials,
Год журнала:
2020,
Номер
32(11)
Опубликована: Фев. 5, 2020
Abstract
Development
of
stimuli‐responsive
materials
with
complex
practical
functions
is
significant
for
achieving
bioinspired
artificial
intelligence.
It
challenging
to
fabricate
hydrogels
showing
simultaneous
changes
in
fluorescence
color,
brightness,
and
shape
response
a
single
stimulus.
Herein,
bilayer
hydrogel
strategy
designed
by
utilizing
an
aggregation‐induced
emission
luminogen,
tetra‐(4‐pyridylphenyl)ethylene
(TPE‐4Py),
the
above
capabilities.
Bilayer
actuators
ionomer
poly(acrylamide‐
r
‐sodium
4‐styrenesulfonate)
(PAS)
as
matrix
both
active
passive
layers
TPE‐4Py
core
function
element
layer
are
prepared.
At
acidic
pH,
protonation
leads
color
brightness
electrostatic
interactions
between
protonated
benzenesulfonate
groups
PAS
chains
cause
deform.
The
proposed
TPE‐4Py/PAS‐based
such
responsiveness
stimulus
provide
insights
design
intelligent
systems
highly
attractive
material
candidates
fields
3D/4D
printing,
soft
robots,
smart
wearable
devices.
Advanced Materials,
Год журнала:
2021,
Номер
33(33)
Опубликована: Июль 3, 2021
Abstract
Chromophores
that
exhibit
aggregation‐induced
emission
(i.e.,
luminogens
[AIEgens])
emit
intense
fluorescence
in
their
aggregated
states,
but
show
negligible
as
discrete
molecular
species
solution
due
to
the
changes
restriction
and
freedom
of
intramolecular
motions.
As
solvent‐swollen
quasi‐solids
with
both
a
compact
phase
free
space,
gels
enable
manipulation
Thus,
AIE‐active
have
attracted
significant
interest
owing
various
distinctive
properties
promising
application
potential.
Herein,
comprehensive
overview
is
provided.
The
fabrication
strategies
employed
are
detailed,
applications
AIEgens
summarized.
In
addition,
gel
functions
arising
from
AIE
moieties
revealed,
along
structure–property
relationships.
Furthermore,
diverse
areas
illustrated.
Finally,
ongoing
challenges
potential
means
address
them
discussed,
future
perspectives
on
gels,
overall
aim
inspiring
research
novel
materials
ideas.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(19), С. 6715 - 6753
Опубликована: Янв. 1, 2023
This
review
not
only
highlights
the
progress
of
emission
and
electronic
behaviour
new
pyrene-based
luminescence
molecules
in
aggregated
state,
but
also
provides
a
perspective
for
understanding
mechanism
optoelectronic
properties
pyrenes.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(30)
Опубликована: Май 11, 2022
Nonradiative
decay
invariably
competes
with
radiative
during
the
deexcitation
process
of
matter.
In
community
luminescence
research,
nonradiative
has
been
deemed
less
attractive
than
decay.
However,
all
things
in
their
being
are
good
for
something
and
so
is
As
molecular
motion-facilitated
(MMFND)
effect
inevitable
photophysical
processes,
it
provides
a
new
avenue
to
convert
harvested
light
energy
into
exploitable
forms
by
harnessing
motion.
many
cases,
active
motion
enables
thermal
deactivation
from
excited
states.
this
Minireview,
recent
advances
photothermal
photoacoustic
systems
MMFND
character
summarized.
We
believe
that
presentation
rational
engineering
efficient
generation
will
deepen
understanding
relationship
between
navigate
people
rethink
positive
aspects
establishment
light-controllable
techniques.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(18), С. 7752 - 7778
Опубликована: Янв. 1, 2022
Ferroptosis
is
an
iron-dependent,
non-apoptotic
form
of
programmed
cell
death
driven
by
excessive
lipid
peroxidation
(LPO).
Mounting
evidence
suggests
that
the
unique
modality
involved
in
development
and
progression
several
diseases
including
cancer,
cardiovascular
(CVDs),
neurodegenerative
disorders,
etc.
However,
pathogenesis
signalling
pathways
ferroptosis
are
not
fully
understood,
possibly
due
to
lack
robust
tools
for
highly
selective
sensitive
imaging
analytes
complex
living
systems.
Up
now,
various
small-molecule
fluorescent
probes
have
been
applied
as
promising
chemosensors
studying
through
tracking
biomolecules
or
microenvironment-related
parameters
vitro
vivo.
In
this
review,
we
comprehensively
reviewed
recent
ferroptosis,
with
a
focus
on
analytes,
design
strategies
bioimaging
applications.
We
also
provided
new
insights
overcome
major
challenges
emerging
field.
Chemical Reviews,
Год журнала:
2024,
Номер
124(20), С. 11242 - 11347
Опубликована: Окт. 9, 2024
Biopsy,
including
tissue
and
liquid
biopsy,
offers
comprehensive
real-time
physiological
pathological
information
for
disease
detection,
diagnosis,
monitoring.
Fluorescent
probes
are
frequently
selected
to
obtain
adequate
on
processes
in
a
rapid
minimally
invasive
manner
based
their
advantages
biopsy.
However,
conventional
fluorescent
have
been
found
show
aggregation-caused
quenching
(ACQ)
properties,
impeding
greater
progresses
this
area.
Since
the
discovery
of
aggregation-induced
emission
luminogen
(AIEgen)
promoted
advancements
molecular
bionanomaterials
owing
unique
high
quantum
yield
(QY)
signal-to-noise
ratio
(SNR),
