Drug Discovery Today, Год журнала: 2023, Номер 28(6), С. 103602 - 103602
Опубликована: Апрель 28, 2023
Язык: Английский
Chemical Engineering Journal, Год журнала: 2023, Номер 469, С. 143924 - 143924
Опубликована: Июнь 3, 2023
Язык: Английский
Процитировано
114
Materials & Design, Год журнала: 2023, Номер 233, С. 112231 - 112231
Опубликована: Авг. 9, 2023
Bacterial infection continues to be one of the biggest threats human health. The therapeutic effect is significantly reduced as a result development super-bacteria-resistant bacteria due overuse antibiotics for conventional antimicrobial treatment. emergence drug-resistant makes it necessary develop new treatments. Following successful application photothermal therapy in field oncology treatment, more and researchers are applying treatments achieving important results, especially treatment bacterial infections. As non-invasive anti-infection method, has advantages broad-spectrum properties, short period, low systemic impact. In PTT, efficacy strongly depends on different laser properties choice agents (PTAs). purpose this review discuss most recent developments nanomaterials that antibacterial. We will delve into principles spectrum PTAs provide summary current synthesis, classification, structural features, physicochemical antibacterial performance research. challenges future prospects enhanced cytotoxicity investigated.
Язык: Английский
Процитировано
84
Biomaterials Research, Год журнала: 2022, Номер 26(1)
Опубликована: Сен. 30, 2022
Near-infrared-II (NIR-II, 1000-1700 nm) light-triggered photothermal therapy (PTT) has been regarded as a promising candidate for cancer treatment, but PTT alone often fails to achieve satisfactory curative outcomes. Hollow nanoplatforms prove be attractive in the biomedical field owing merits including good biocompatibility, intrinsic physical-chemical nature and unique hollow structures, etc. On one hand, themselves can NIR-II agents (PTAs), cavities of which are able carry diverse therapeutic units realize multi-modal therapies. other PTAs capable decorating on surface combine with functions components encapsulated inside synergistic treatment. Notably, generally serve photoacoustic imaging (PAI) contrast (CAs), means such kind also expected multifunctional all-in-one nanotheranostics. In this review, recent advances single-modal PTT, dual-modal PTT/photodynamic (PDT), PTT/chemotherapy, PTT/catalytic PTT/gas well PTT/chemodynamic (CDT)/chemotherapy, PTT/chemo/gene PTT/PDT/CDT/starvation (ST)/immunotherapy summarized first time. Before these, typical synthetic strategies structures presented, lastly, potential challenges perspectives related these novel paradigms future research clinical translation discussed.
Язык: Английский
Процитировано
82
RSC Advances, Год журнала: 2023, Номер 13(21), С. 14443 - 14460
Опубликована: Янв. 1, 2023
This review summarizes the common inorganic and organic photothermal nanoagents their applications in tumor therapy. Additionally, challenges future prospects of nanomaterial-based therapy cancer treatment are discussed.
Язык: Английский
Процитировано
81
Nano-Micro Letters, Год журнала: 2023, Номер 16(1)
Опубликована: Ноя. 21, 2023
Since the discovery of enzyme-like activity Fe
Язык: Английский
Процитировано
74
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Сен. 27, 2023
Abstract Near-infrared (NIR) organic small molecule dyes (OSMDs) are effective photothermal agents for therapy (PTT) due to their advantages of low cost and toxicity, good biodegradation, strong NIR absorption over a wide wavelength range. Nevertheless, OSMDs have limited applicability in PTT conversion efficiency inadequate destruction tumor regions that nonirradiated by light. However, they can also act as photosensitizers (PSs) produce reactive oxygen species (ROS), which be further eradicated using ROS-related therapies address the above limitations PTT. In this review, synergistic mechanism, composition, properties photodynamic (PDT)–PTT nanoplatforms were comprehensively discussed. addition, some specific strategies improving combined PDT based on cancer completely eradicate cells outlined. These include performing image-guided co-therapy, enhancing infiltration, increasing H 2 O or microenvironment, loading anticancer drugs onto enable with phototherapy chemotherapy. Meanwhile, intriguing prospects challenges treatment modality summarized focus future trends its clinical application. Graphical
Язык: Английский
Процитировано
67
Coordination Chemistry Reviews, Год журнала: 2023, Номер 501, С. 215560 - 215560
Опубликована: Ноя. 27, 2023
Язык: Английский
Процитировано
60
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Окт. 17, 2023
Human serum albumin (HSA) based drug delivery platforms that feature desirable biocompatibility and pharmacokinetic property are rapidly developed for tumor-targeted delivery. Even though various HSA-based have been established, it is still of great significance to develop more efficient preparation technology broaden the therapeutic applications nano-carriers. Here we report a bridging strategy unfastens HSA polypeptide chains subsequently crosslinks these by bridge-like molecule (BPY-Mal2) afford reassemblies formulation (BPY@HSA) with enhanced loading capacity, endowing BPY@HSA uniformed size, high photothermal efficacy, favorable features. Both in vitro vivo studies demonstrate presents higher efficacy prominent performance than conventionally prepared formulation. The feasibility preparation, stability, conversion may facilitate as an agents (PTAs) tumor therapy (PTT). This work provides facile enhance capacity crosslinking order improve effect.
Язык: Английский
Процитировано
48
Exploration, Год журнала: 2024, Номер 4(6)
Опубликована: Март 24, 2024
Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.
Язык: Английский
Процитировано
42
Advanced Materials, Год журнала: 2024, Номер 36(31)
Опубликована: Май 21, 2024
Fluorescence imaging (FLI)-guided phototheranostics using emission from the second near-infrared (NIR-II) window show significant potential for cancer diagnosis and treatment. Clinical imaging-used polymethine ionic indocyanine green (ICG) dye is widely adopted NIR fluorescence imaging-guided photothermal therapy (PTT) research due to its exceptional photophysical properties. However, ICG has limitations such as poor photostability, low conversion efficiency (PCE), short-wavelength peak, liver-targeting issues, which restrict wider use. In this study, two derivatives are transformed into neutral merocyanines (mCy) achieve much-enhanced performance NIR-II phototheranostics. Initial designs of dyes similar drawbacks in terms photostability performance. One modified molecules, mCy890, shows significantly improved stability, an peak over 1000 nm, a high PCE 51%, all considerably outperform ICG. vivo studies demonstrate that nanoparticles mCy890 can effectively accumulate at tumor sites guided by imaging. This provides valuable insights development enhanced
Язык: Английский
Процитировано
25