Talanta, Год журнала: 2023, Номер 260, С. 124628 - 124628
Опубликована: Май 5, 2023
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2023, Номер 482, С. 215080 - 215080
Опубликована: Фев. 21, 2023
Язык: Английский
Процитировано
130
Chemical Society Reviews, Год журнала: 2023, Номер 52(8), С. 2790 - 2832
Опубликована: Янв. 1, 2023
Organometallics act through specific biomolecular targets or tumor homeostasis perturbation to induce various cell death pathways.
Язык: Английский
Процитировано
100
Coordination Chemistry Reviews, Год журнала: 2023, Номер 486, С. 215130 - 215130
Опубликована: Апрель 10, 2023
Язык: Английский
Процитировано
97
Redox Biology, Год журнала: 2023, Номер 67, С. 102906 - 102906
Опубликована: Окт. 4, 2023
Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a primary catalyst for microcirculation dysfunction and enterogenous infection. Previous studies have mainly focused on how neutrophil extracellular traps (NETs) ferroptosis cause epithelial injury, little attention has been given to NETs, from circulatory neutrophils, affect cells during II/R. This study aimed unravel the mechanisms through which NETs microvascular dysfunction. We first detected heightened local NET infiltration around microvasculature, accompanied increased cell ferroptosis, resulting in both human animal II/R models. However, administration of inhibitor ferrostatin-1 or inhibition via neutrophil-specific peptidylarginine deiminase 4 (Pad4) deficiency led positive outcomes, with reduced function recovery. Moreover, RNA-seq analysis revealed significant enrichment mitophagy- ferroptosis-related signaling pathways HUVECs incubated NETs. Mechanistically, elevated formation induced Fundc1 phosphorylation at Tyr18 cells, mitophagy inhibition, mitochondrial quality control imbalance, excessive ROS generation lipid peroxidation, Nevertheless, using activator urolithin A AAV-Fundc1 transfection could reverse this process ameliorate damage. demonstrate that NETosis result microcirculatory conclude suppressed can mitigate improving Fundc1-dependent mitophagy. Targeting be promising approach treating II/R-induced
Язык: Английский
Процитировано
67
Chemical Society Reviews, Год журнала: 2023, Номер 52(18), С. 6447 - 6496
Опубликована: Янв. 1, 2023
This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.
Язык: Английский
Процитировано
51
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.
Язык: Английский
Процитировано
7
Sensors and Actuators B Chemical, Год журнала: 2023, Номер 392, С. 134041 - 134041
Опубликована: Май 29, 2023
Язык: Английский
Процитировано
37
Analytical Chemistry, Год журнала: 2023, Номер 95(15), С. 6287 - 6294
Опубликована: Апрель 4, 2023
Mitochondrial membrane potential (MMP) and sulfur dioxide (SO2) significantly affect the mitochondrial state. In this work, TC-2 TC-8 were constructed through side-chain engineering, in which bearing poorer hydrophobicity could localize on mitochondria better. Interestingly, short-wave emission was captured due to sensitive response of SO2 (LOD = 13.8 nM). Meanwhile, probe bind with DNA, presenting enhanced long-wave emission. Encouragingly, migrate from nucleus when MMP decreased, accompanied by increase fluorescence lifetime (9-fold). Hence, be used for dual-channel monitoring MMP, showed a completely different pathway commercial detectors JC-1/JC-10. The cellular experiments that gradually decreased reactive oxygen species-triggered oxidative stress, level up-regulated simultaneously. Overall, work proposed new method investigate diagnose mitochondrial-related diseases.
Язык: Английский
Процитировано
28
TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 168, С. 117327 - 117327
Опубликована: Сен. 23, 2023
Язык: Английский
Процитировано
24
Analytical Chemistry, Год журнала: 2024, Номер 96(11), С. 4570 - 4579
Опубликована: Март 5, 2024
Ferroptosis, as a new form of regulated cell death, is implicated in various physiological and pathological processes. Developing single probe for an independent analysis multiple analytes related to ferroptosis can provide more accurate information simplify the detection procedures, but it faces great challenges. In this work, we develop fluorescent simultaneous GSH through ratiometric fluorescence response microviscosity via lifetime model. Based on reversible Michael addition reaction between unsaturated C═C bond, responds reversibly with variation fast time (t1/2 = 4.7 s). At same time, sensitive environmental viscosity by changing its lifetimes. The was applied monitor drug-induced process both classical Xc–/GSH/GPX4- DHODH-mediated defense mechanisms. We hope that will useful molecular tool real-time live-cell imaging dynamics, which benefit unveiling
Язык: Английский
Процитировано
16