Gels,
Год журнала:
2024,
Номер
10(8), С. 513 - 513
Опубликована: Авг. 3, 2024
Nanoclay-composite
hydrogels
represent
a
promising
avenue
for
advancing
bone
tissue
engineering.
Traditional
face
challenges
in
providing
mechanical
strength,
biocompatibility,
and
bioactivity
necessary
successful
regeneration.
The
incorporation
of
nanoclay
into
hydrogel
matrices
offers
potential
unique
solution
to
these
challenges.
This
review
provides
comprehensive
overview
the
fabrication,
physico-chemical/biological
performance,
applications
nanoclay-composite
Various
fabrication
techniques,
including
situ
polymerization,
physical
blending,
3D
printing,
are
discussed.
In
vitro
vivo
studies
evaluating
biocompatibility
have
demonstrated
promoting
cell
adhesion,
proliferation,
differentiation.
Their
defect
repair,
osteochondral
engineering
drug
delivery
also
explored.
Despite
their
engineering,
such
as
optimal
dispersion,
scalability,
long-term
stability,
regulatory
approval,
integration
with
emerging
technologies
achieve
clinical
application.
Future
research
directions
need
focus
on
refining
enhancing
understanding
biological
interactions,
towards
translation
commercialization.
Overall,
offer
exciting
opportunities
improving
regeneration
strategies.
Biomimetics,
Год журнала:
2023,
Номер
8(1), С. 16 - 16
Опубликована: Янв. 2, 2023
Regenerative
medicine
has
received
potential
attention
around
the
globe,
with
improving
cell
performances,
one
of
necessary
ideas
for
advancements
regenerative
medicine.
It
is
crucial
to
enhance
performances
in
physiological
system
drug
release
studies
because
variation
environments
between
vitro
and
vivo
develops
a
loop
estimation.
On
other
hand,
tissue
engineering
path
integrate
cells
scaffold
biomaterials
produce
growth
factors
regenerate
organs.
Scaffold
are
prototype
production
perform
vital
functions
engineering.
Silk
fibroin
natural
fibrous
polymer
significant
usage
growing
interest
leftovers
silk
Among
various
biopolymer-based
biomaterials,
fibroin-based
have
attracted
due
their
outstanding
mechanical
properties,
biocompatibility,
hemocompatibility,
biodegradability
applications.
This
review
article
focused
on
highlighting
recent
3D
printing
technologies
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 15, 2024
This
review
explores
the
mechanisms
of
chronic
radiation-induced
skin
injury
fibrosis,
focusing
on
transition
from
acute
radiation
damage
to
a
fibrotic
state.
It
reviewed
cellular
and
molecular
responses
radiation,
highlighting
role
myofibroblasts
significant
impact
Transforming
Growth
Factor-beta
(TGF-β)
in
promoting
fibroblast-to-myofibroblast
transformation.
The
delves
into
epigenetic
regulation
gene
expression,
contribution
extracellular
matrix
proteins
microenvironment,
immune
system
context
fibrosis.
Additionally,
it
discusses
potential
biomaterials
artificial
intelligence
medical
research
advance
understanding
treatment
suggesting
future
directions
involving
bioinformatics
personalized
therapeutic
strategies
enhance
patient
quality
life.
npj Materials Degradation,
Год журнала:
2024,
Номер
8(1)
Опубликована: Июль 6, 2024
Abstract
The
biological
response
to
biomaterials
plays
a
crucial
role
in
selecting
suitable
materials
for
the
formulation
and
development
of
tissue
engineering
platforms.
Biodegradation
is
one
properties
that
considered
appropriate
biomedical
applications.
process
breaking
down
large
molecules
into
smaller
with/without
aid
catalytic
enzymes.
biodegradation
chemical
absorption,
distribution,
metabolism,
excretion,
toxicity
(ADMET)
small
body.
Degradation
can
be
followed
by
assessing
physical,
mechanical,
attributes
biomaterials.
There
are
several
techniques/parameters
targeted
when
studying
degradation
biomaterials,
with
gravimetric
analysis,
surface
erosion,
morphological
changes
being
largely
employed
techniques.
However,
techniques
present
few
limitations,
such
as
technical
errors
material
solubility
mistaken
degradation,
these
infer
but
not
confirm
they
do
provide
composition
fragmenting/fragmented
molecules.
American
Society
Testing
Materials
(ASTM)
guidelines
parameters
biodegradation.
ASTM
assessment
approaches
need
updated
sufficient
evidence
draw
conclusive
decisions
regarding
In
this
review,
critically
reviewed
about
their
advantages
disadvantages,
suggestions
on
how
still
play
This
review
could
assist
researchers
employ
cost-effective,
efficient,
multiple
evaluate
information
Suggested
future
should
include
measuring
(such
chemical,
or
physical
biomaterials)
real-time,
employing
non-invasive,
continuous,
automated
processes.
Gels,
Год журнала:
2024,
Номер
10(8), С. 513 - 513
Опубликована: Авг. 3, 2024
Nanoclay-composite
hydrogels
represent
a
promising
avenue
for
advancing
bone
tissue
engineering.
Traditional
face
challenges
in
providing
mechanical
strength,
biocompatibility,
and
bioactivity
necessary
successful
regeneration.
The
incorporation
of
nanoclay
into
hydrogel
matrices
offers
potential
unique
solution
to
these
challenges.
This
review
provides
comprehensive
overview
the
fabrication,
physico-chemical/biological
performance,
applications
nanoclay-composite
Various
fabrication
techniques,
including
situ
polymerization,
physical
blending,
3D
printing,
are
discussed.
In
vitro
vivo
studies
evaluating
biocompatibility
have
demonstrated
promoting
cell
adhesion,
proliferation,
differentiation.
Their
defect
repair,
osteochondral
engineering
drug
delivery
also
explored.
Despite
their
engineering,
such
as
optimal
dispersion,
scalability,
long-term
stability,
regulatory
approval,
integration
with
emerging
technologies
achieve
clinical
application.
Future
research
directions
need
focus
on
refining
enhancing
understanding
biological
interactions,
towards
translation
commercialization.
Overall,
offer
exciting
opportunities
improving
regeneration
strategies.
