Neutrophil membrane fusogenic nanoliposomal leonurine for targeted ischemic stroke therapy via remodeling cerebral niche and restoring blood-brain barrier integrity DOI Creative Commons
Zhuang Tang, Shiyu Meng, Zhiling Song

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100674 - 100674

Published: May 19, 2023

Ischemic stroke (IS) constitutes the leading cause of global morbidity and mortality. Neuroprotectants are essential to ameliorate clinical prognosis, but their therapeutic outcomes tremendously compromised by insufficient delivery ischemic lesion intricate pathogenesis associated with neuronal damage, oxidative stress, inflammation responses, blood-brain barrier (BBB) dysfunction, etc. Herein, a biomimetic nanosystem (Leo@NM-Lipo) composed neutrophil membrane-fused nanoliposomal leonurine (Leo) is constructed, which can not only efficiently penetrate repair disrupted BBB also robustly remodel harsh cerebral microenvironment reverse ischemia-reperfusion (I/R) injury. More specifically, membrane inherits penetrating, infarct core targeting, neutralization, immune evasion properties neutrophils, while Leo, naturally occurring neuroprotectant, exerts pleiotropic effects attenuate brain damage. Remarkably, comprehensive investigations disclose critical factors influencing targetability performances nanosystems. Leo@NM-Lipo low protein-to-lipid ratio 1:10 targets rescues injured alleviating apoptosis, neuroinflammation, restoring integrity in transient middle artery occlusion (tMCAO) rats. Taken together, our study provides neutrophil-mimetic nanoplatform for targeted IS therapy sheds light on rational design nanosystems favoring wide medical applications.

Language: Английский

Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications DOI
Joana Lopes, Daniela Lopes, Miguel Pereira‐Silva

et al.

Small Methods, Journal Year: 2022, Volume and Issue: 6(8)

Published: June 29, 2022

Abstract Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage nanoparticles circumvent some limitations of nanoscale materials. This emergent membrane‐coating technology is inspired by naturally occurring intercellular interactions, efficiently guide nanostructures the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, intrinsic biocompatibility membranes allows crossing biological barriers avoids elimination immune system. results in enhanced blood circulation time lower toxicity vivo. Macrophages are major phagocytic cells innate They equipped with a complex repertoire surface receptors, enabling them respond signals, exhibit tropism inflammatory sites tumorous tissues. Macrophage membrane‐functionalized nanosystems designed combine advantages macrophages nanomaterials, improving ability those reach target sites. Recent studies have demonstrated potential these biomimetic for targeted delivery drugs imaging agents tumors, inflammatory, infected The present review covers preparation biomedical applications macrophage membrane‐coated nanosystems. Challenges future perspectives development addressed.

Language: Английский

Citations

139
Biomimetic cell membrane‐coated poly(lactic‐ co ‐glycolic acid) nanoparticles for biomedical applications DOI Creative Commons
Nasrullah Jan, Asadullah Madni, Safiullah Khan

et al.

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(2)

Published: Nov. 2, 2022

Abstract Poly(lactic‐ co ‐glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability sustained controlled release. To prolong NP circulation time, enable target‐specific overcome physiological barriers, NPs camouflaged in cell membranes have been developed evaluated to improve delivery. Here, we discuss recent advances membrane‐coated PLGA NPs, preparation methods, application cancer therapy, management inflammation, treatment cardiovascular disease control infection. We address the current challenges highlight future research directions needed effective use membrane‐camouflaged NPs.

Language: Английский

Citations

84
Magnetic Nanoparticles for Medical Applications: Updated Review DOI Creative Commons
Guadalupe G. Flores‐Rojas, Felipe López‐Saucedo, Ricardo Vera‐Graziano

et al.

Macromol—A Journal of Macromolecular Research, Journal Year: 2022, Volume and Issue: 2(3), P. 374 - 390

Published: Aug. 2, 2022

Magnetic nanoparticles (MNPs) represent an advanced tool in the medical field because they can be modified according to biomedical approaches and guided by external magnetic human body. The first objective of this review is exemplify some promising applications field, including smart drug-delivery systems, therapies against cancer cells, radiotherapy, improvements diagnostics using resonance imaging (MRI), tissue engineering. Complementarily, second illustrate mechanisms action theoretical foundations related magnetoresponsive materials.

Language: Английский

Citations

76
Immuno‐Engineered Nanodecoys for the Multi‐Target Anti‐Inflammatory Treatment of Autoimmune Diseases DOI
Mengying Hou, Yuansong Wei, Ziyin Zhao

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(12)

Published: Jan. 19, 2022

Overactivated T cells and overproduced pro-inflammatory cytokines form a self-amplified signaling loop to continuously exacerbate the dysregulated inflammatory response propel progression of autoimmune diseases (AIDs). Herein, immuno-engineered nanodecoys (NDs) based on poly(lactic-co-glycolic acid) nanoparticles coated with programmed death-ligand 1 (PD-L1)-expressing macrophage membrane (PRM) are developed mediate multi-target interruption self-promoted cascade in AIDs. The PRM collected from IFN-γ-treated RAW 264.7 possesses elevated surface levels adhesion molecule receptors cytokine receptors, and, thus, systemically administered NDs afford higher accumulation level inflamed tissues stronger scavenging efficiency toward multiple cytokines. More importantly, IFN-γ treatment induces remarkable PD-L1 expression PRM, thereby allowing bind membrane-bound death-1 (PD-1) CD4+ cell surfaces or neutralize free soluble PD-1, which reconstructs PD-1/PD-L1 inhibitory axis suppress activation restore immune tolerance. As such, provoke potent cooperative anti-inflammatory immune-suppressive efficacies alleviate damages Zymosan A-induced arthritis mice dextran sulfate sodium-induced ulcerative colitis mice. This study provides an enlightened example for immuno-engineering cell-membrane-based NDs, rendering promising implications into AIDs via immune-modulation.

Language: Английский

Citations

75
Cell membrane-coated nanomaterials for cancer therapy DOI Creative Commons
Shiying Zeng,

Qinglai Tang,

Minna Xiao

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100633 - 100633

Published: April 12, 2023

With the development of nanotechnology, nanoparticles have emerged as a delivery carrier for tumor drug therapy, which can improve therapeutic effect by increasing stability and solubility prolonging half-life drugs. However, are foreign substances humans, easily cleared immune system, less targeted to tumors, may even be toxic body. As natural biological material, cell membranes unique properties, such good biocompatibility, strong targeting ability, ability evade surveillance, high drug-carrying capacity. In this article, we review membrane-coated (CMNPs) their applications therapy. First, briefly describe CMNP characteristics applications. Second, present advantages different well nanoparticles, provide brief description process CMNPs, discuss current status application summarize shortcomings use in cancer propose future research directions. This summarizes progress on CMNPs therapy recent years assesses remaining problems, providing scholars with new ideas

Language: Английский

Citations

53
Revolutionizing Neurocare: Biomimetic Nanodelivery Via Cell Membranes DOI
Jun Liao, Lidong Gong,

Qingqiang Xu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: April 7, 2024

Abstract Brain disorders represent a significant challenge in medical science due to the formidable blood–brain barrier (BBB), which severely limits penetration of conventional therapeutics, hindering effective treatment strategies. This review delves into innovative realm biomimetic nanodelivery systems, including stem cell‐derived nanoghosts, tumor cell membrane‐coated nanoparticles, and erythrocyte membrane‐based carriers, highlighting their potential circumvent BBB's restrictions. By mimicking native properties, these nanocarriers emerge as promising solution for enhancing drug delivery brain, offering strategic advantage overcoming barrier's selective permeability. The unique benefits leveraging membranes from various sources is evaluated advanced technologies fabricating membrane‐encapsulated nanoparticles capable masquerading endogenous cells are examined. enables targeted broad spectrum therapeutic agents, ranging small molecule drugs proteins, thereby providing an approach neurocare. Further, contrasts capabilities limitations with traditional methods, underlining enable targeted, sustained, minimally invasive modalities. concluded perspective on clinical translation underscoring transformative impact landscape intractable brain diseases.

Language: Английский

Citations

28
Macrophage based drug delivery: Key challenges and strategies DOI Creative Commons
Qian Guo, Zhong‐Ming Qian

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 55 - 72

Published: April 23, 2024

As a natural immune cell and antigen presenting cell, macrophages have been studied engineered to treat human diseases. Macrophages are well-suited for use as drug carriers because of their biological characteristics, such excellent biocompatibility, long circulation, intrinsic inflammatory homing phagocytosis. Meanwhile, macrophages' uniquely high plasticity easy re-education polarization facilitates part efficacious therapeutics the treatment diseases or tumors. Although recent studies demonstrated promising advances in macrophage-based delivery, several challenges currently hinder further improvement therapeutic effect clinical application. This article focuses on main utilizing from selection macrophage sources, loading, maintenance phenotypes, migration release at target sites. In addition, corresponding strategies insights related these described. Finally, we also provide perspective shortcomings road translation production.

Language: Английский

Citations

22
Anti-inflammatory mechanisms of neutrophil membrane-coated nanoparticles without drug loading DOI
Qing Zhang,

Chengyi Hu,

Jinwei Feng

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 369, P. 12 - 24

Published: March 21, 2024

Language: Английский

Citations

20
Biomimetic Exosomes: A New Generation of Drug Delivery System DOI Creative Commons
Xudong Wang, Xian Zhao,

Youxiu Zhong

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: May 23, 2022

Most of the naked drugs, including small molecules, inorganic agents, and biomacromolecule cannot be used directly for disease treatment because their poor stability undesirable pharmacokinetic behavior. Their shortcomings might seriously affect exertion therapeutic effects. Recently, a variety exogenous endogenous nanomaterials have been developed as carriers drug delivery. Among them, exosomes attracted great attention due to excellent biocompatibility, low immunogenicity, toxicity, ability overcome biological barriers. However, delivery significant challenges, such yields, complex contents, homogeneity, which limit application. Engineered or biomimetic fabricated through approaches tackle these drawbacks. We summarized recent advances in over past decades addressed opportunities challenges next-generation system.

Language: Английский

Citations

45
Engineered biomembrane-derived nanoparticles for nanoscale theranostics DOI Creative Commons

Ziqing Wu,

Hao Zhang, Jing Yan

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 13(1), P. 20 - 39

Published: Nov. 29, 2022

Currently, biological membrane-derived nanoparticles (NPs) have shown enormous potential as drug delivery vehicles due to their outstanding biomimetic properties.To make these NPs more adaptive complex systems, some methods been developed modify biomembranes and endow them with functions while preserving inherent natures.In this review, we introduce five common approaches used for biomembrane decoration: membrane hybridization, the postinsertion method, chemical methods, metabolism engineering gene engineering.These can functionalize a series of derived from red blood cells, white tumor platelets, exosomes so on.Biomembrane could markedly facilitate targeted delivery, treatment diagnosis cancer, inflammation, immunological diseases, bone diseases Alzheimer's disease.It is anticipated that modification techniques will advance biomembrane-derived into broader applications in future.

Language: Английский

Citations

43