Biomimetic ZIF-8 Nanoparticles: A Novel Approach for Biomimetic Drug Delivery Systems

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 5523 - 5544

Опубликована: Июнь 1, 2024

Metal-organic frameworks (MOFs) are porous materials resulting from the coordination of metal clusters or ions with organic ligands, merging macromolecular and chemistry features. Among these, zeolitic imidazolate framework-8 (ZIF-8) stands out as a widely utilized MOF known for its robust stability in aqueous environments owing to interaction between constituent zinc (Zn

Язык: Английский

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A Review: Surface Engineering of Lipid‐Based Drug Delivery Systems

Small, Год журнала: 2024, Номер 20(43)

Опубликована: Июль 14, 2024

This review explores the evolution of lipid-based nanoparticles (LBNPs) for drug delivery (DD). Herein, LBNPs are classified into liposomes and cell membrane-based (CMNPs), each with unique advantages challenges. Conventional possess drawbacks such as poor targeting, quick clearance, limited biocompatibility. One possible alternatives to overcome these challenges is surface modification (NPs) materials polyethylene glycol (PEG), aptamers, antibody fragments, peptides, CD44, hyaluronic acid, folic palmitic lactoferrin. Thus, main focus this will be on different modifications that enable have beneficial properties DD, enhancing mass transport properties, immune evasion, improved stability, targeting. Moreover, various CMNPs explored used DD derived from cells red blood (RBCs), platelets, leukocytes, cancer cells, stem highlighting their natural (e.g., biocompatibility ability evade system). discussion extends biomimicking hybrid NPs accomplished through coating synthetic (mainly polymeric) membranes. aims provide a comprehensive resource researchers recent advances in field CMNPs. Overall, provides valuable insights dynamic systems.

Язык: Английский

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Neutrophil heterogeneity and plasticity: unveiling the multifaceted roles in health and disease

MedComm, Год журнала: 2025, Номер 6(2)

Опубликована: Янв. 21, 2025

Abstract Neutrophils, the most abundant circulating leukocytes, have long been recognized as key players in innate immunity and inflammation. However, recent discoveries unveil their remarkable heterogeneity plasticity, challenging traditional view of neutrophils a homogeneous population with limited functional repertoire. Advances single‐cell technologies assays revealed distinct neutrophil subsets diverse phenotypes functions ability to adapt microenvironmental cues. This review provides comprehensive overview multidimensional landscape heterogeneity, discussing various axes along which diversity manifests, including maturation state, density, surface marker expression, polarization. We highlight molecular mechanisms underpinning focusing on complex interplay signaling pathways, transcriptional regulators, epigenetic modifications that shape responses. Furthermore, we explore implications plasticity physiological processes pathological conditions, host defense, inflammation, tissue repair, cancer. By integrating insights from cutting‐edge research, this aims provide framework for understanding multifaceted roles potential therapeutic targets wide range diseases.

Язык: Английский

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A cerium single-atom catalyst enables targeted catalytic therapy for acute kidney injury via neutrophil hitchhiking

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 404 - 416

Опубликована: Фев. 10, 2025

Язык: Английский

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Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming

Cellular and Molecular Immunology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Abstract Macrophage polarization and energy metabolic reprogramming play pivotal roles in the onset progression of inflammatory arthritis. Moreover, although previous studies have reported that proviral integration Moloney virus 2 (Pim2) kinase is involved various cancers through mediation aerobic glycolysis cancer cells, its role arthritis remains unclear. In this study, we demonstrated multiple enzymes are activated upon Pim2 upregulation during M1 macrophage polarization. Specifically, directly phosphorylates PGK1-S203, PDHA1-S300, PFKFB2-S466, thereby promoting glycolytic reprogramming. expression was elevated macrophages from patients with collagen-induced (CIA) model mice. Conditional knockout or administration inhibitor HJ-PI01 attenuated development by inhibiting Through molecular docking dynamic simulation, bexarotene identified as an inhibits downstream polarization, mitigating For targeted treatment, neutrophil membrane-coated (Bex)-loaded PLGA-based nanoparticles (NM@NP-Bex) were developed to slow suppressing macrophages, these (NPs) exhibited superior therapeutic effects fewer side effects. Taken together, results our study targeting inhibition could effectively alleviate via reversal M1/M2 imbalance. NM@NPs loaded represent a promising strategy for treatment

Язык: Английский

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Physically engineered extracellular vesicles targeted delivering miR-21-5p to promote renoprotection after renal ischemia-reperfusion injury

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101528 - 101528

Опубликована: Янв. 30, 2025

Acute kidney injury (AKI) resulting from ischemia-reperfusion (IRI) is a common challenge in various clinical practices, yet effective therapies remain elusive. Endothelial plays crucial role the pathogenesis of renal IRI. progenitor cells (EPCs) derived extracellular vesicles (EVs) hold promise as cell-free for treating IRI; however, their efficacy limited by low delivery efficiency. In this study, we developed neutrophils (NEs) membrane-modified EVs (N-EVs) exploiting natural properties NEs to target damaged endothelium. N-EVs inherited characteristic membrane proteins along with biological functions EPCs-EVs. Results vitro and vivo experiments demonstrated that significantly enhanced targeting efficiency towards IRI kidneys via P-selectin glycoprotein ligand-1 (PSGL-1). Moreover, effectively promoted proliferation, migration, tube-formation abilities injured endothelial (ECs) contributed overall function improvement through targeted miR-21-5p. Additionally, could restore integrity, reduce cytokine release, inhibit leukocyte infiltration, hence alleviating inflammation. conclusion, our accessible engineering approach represents promising strategy Furthermore, hybrid modification can be tailored optimized broader applications other diseases.

Язык: Английский

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Biomaterials that passively and actively target macrophages promote the regeneration of injured tissues

Biomedical Technology, Год журнала: 2024, Номер 8, С. 17 - 49

Опубликована: Окт. 1, 2024

Язык: Английский

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Innate immunity-modulating nanobiomaterials for controlling inflammation resolution

Matter, Год журнала: 2024, Номер 7(11), С. 3811 - 3844

Опубликована: Ноя. 1, 2024

Язык: Английский

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From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery

Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(1), С. 15 - 15

Опубликована: Янв. 6, 2025

Biomimetic nanodrug delivery systems based on cell membranes have emerged as a promising approach for targeted cancer therapy due to their biocompatibility and low immunogenicity. Among them, platelet-mediated are particularly noteworthy innate tumor-homing interaction capabilities. These utilize nanoparticles shielded directed by platelet membrane coatings efficient drug delivery. This review highlights the role of platelets in therapy, summarizes advancements platelet-based systems, discusses integration with other treatments. Additionally, it addresses limitations challenges delivery, offering insights into future developments this innovative field.

Язык: Английский

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Inhalable neutrophil-mimicking nanoparticles for chronic obstructive pulmonary disease treatment

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113648 - 113648

Опубликована: Март 1, 2025

Язык: Английский

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