Medical Oncology, Год журнала: 2024, Номер 42(1)
Опубликована: Дек. 12, 2024
Язык: Английский
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 18, 2025
Clinically, multimodal therapies are adopted worldwide for the management of cancer, which continues to be a leading cause death. In recent years, immunotherapy has firmly established itself as new paradigm in cancer care that activates body's immune defense cope with cancer. Immunotherapy resulted significant breakthroughs treatment stubborn tumors, dramatically improving clinical outcome patients. Multiple forms immunotherapy, including checkpoint inhibitors (ICIs), adoptive cell therapy and vaccines, have become widely available. However, effectiveness these immunotherapies is not much satisfying. Many patients do respond disease recurrence appears unavoidable because rapidly evolving resistance. Moreover, can give rise severe off-target immune-related adverse events. Strategies remove hindrances mainly focus on development combinatorial or exploitation novel immunotherapeutic mediations. Nanomaterials carrying anticancer agents target site considered practical approaches treatment. Nanomedicine combined offers possibility potentiate systemic antitumor immunity facilitate selective cytotoxicity against cells an effective safe manner. A myriad nano-enabled currently under investigation. Owing gaps between preclinical studies, nano-immunotherapy faces multiple challenges, biosafety nanomaterials trial design. this review, we provide overview summarize evidence indicating how nanomedicine-based increase efficacy immunotherapies. We also discuss key challenges emerged era nanotechnology-based immunotherapy. Taken together, combination drawing increasing attention, it anticipated will achieve desired success therapy.
Язык: Английский
Процитировано
15
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(17)
Опубликована: Март 8, 2024
Cancer vaccines provide a potential strategy to cure patients. Their clinical utilization and efficacy is, however, limited by incomplete coverage of tumor neoantigens unspecific restricted activation dendritic cells (DCs). Tumor cell lysates (TCLs) containing broad spectrum neoantigens, while are considered ideal in formulating personalized vaccines, induce generally poor antigen presentation transient antitumor immune response. Here, intelligent polymersomal nanovaccines (PNVs) that quantitatively coload, efficiently codeliver, responsively corelease TCL CpG adjuvant lymph node (LN) DCs developed boost specific robust immunity. PNVs carrying ovalbumin (OVA) markedly enhance the maturation, presentation, downstream T ability bone-marrow-derived strong systemic response after tail base injection. Remarkably, 85% B16-F10 melanoma-bearing mice generate long-lasting anticancer memory at low dose, protecting all cured from rechallenge. These LN-directed being highly versatile straightforward opens new door for cancer vaccines.
Язык: Английский
Процитировано
15
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 17, 2024
Abstract Bacteria have garnered significant attention in tumor immunotherapy recently years, owing to their immune‐activating properties, ease of genetic manipulation, and colonization abilities. In order further enhance the safety, efficacy, clinical translation potential bacterial therapy, endow bacteria with additional functions, modifications or engineering surfaces emerged as a current research hotspot. This review systematically summarizes primary methods strategies for surface modification engineering, including chemical alteration, physical modification, bio‐modification. Subsequently, it is delve into roles these techniques enhancing immunotherapy, such improving immunotherapeutic efficacy reducing toxic side effects, elucidate underlying mechanisms. Finally, challenges faced this field are deeply explored, solutions future presented. work offers comprehensive overview advancements new generation implications bacterial‐based immunotherapy.
Язык: Английский
Процитировано
15
IET Nanobiotechnology, Год журнала: 2024, Номер 2024, С. 1 - 8
Опубликована: Фев. 24, 2024
Cancer vaccines based on tumor cell components have shown promising results in animal and clinical studies. The vaccine system contains abundant antigen components, which can activate the immune by antigens. However, their efficacy has been limited inability of antigens delivery, are core vaccines, further fail to be presented activation effective cells. Nanotechnology offers a novel platform enhance immunogenicity tumor-associated deliver them antigen-presenting cells (APCs) more efficiently. In addition, nanotreatment derivate active ingredients could also help improve effectiveness cancer vaccines. this review, we summarize recent advances development combination nanotechnology tumor-based ingredients, including liposomes, polymeric nanoparticles, metallic virus-like particles membrane, lysate, specific These nanovaccines designed increase uptake, prolong presentation, modulate responses through codelivery immunostimulatory agents. We discuss challenges opportunities translation these nanovaccines.
Язык: Английский
Процитировано
4
Life Sciences, Год журнала: 2024, Номер 352, С. 122897 - 122897
Опубликована: Июль 4, 2024
Язык: Английский
Процитировано
4
International Journal of Pharmaceutics, Год журнала: 2024, Номер 656, С. 124093 - 124093
Опубликована: Апрель 6, 2024
Язык: Английский
Процитировано
3
Precision medicine and engineering., Год журнала: 2025, Номер unknown, С. 100017 - 100017
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Nanotechnology, Год журнала: 2025, Номер 7
Опубликована: Апрель 14, 2025
Cancer arises from the uncontrolled proliferation of tumor cells within body. As incidence cancer continues to rise, its treatment has become a critical focus for clinicians. The body possesses immune surveillance mechanism designed inhibit cells. When tumor-associated mutant antigens appear on cell surface, antigen-presenting cells, as dendritic present these specific such T lymphocytes, thereby promoting an response and enhancing cytotoxic effect Concurrently, system develops memory, akin elicited by vaccination. While traditional diseases like tuberculosis tetanus can be prevented treated through vaccination, development vaccines remains in nascent stages. Tumor-specific originate patient’s own or generated mutation. Thus, presentation tumor-specific is pivotal anti-tumor immunotherapy. Advances nanoscience offer novel approaches Nanoparticles (NPs) engineered nanotechnology have garnered significant attention due their diverse, favorable, stable properties. These NPs effectively encapsulate chemotherapy drugs proteins, facilitating targeted delivery vivo . Common carriers include liposomes, polymeric nanoparticles, metal among others. intelligent systems enhance efficient antigen presentation, augmenting responses. sourced In this review, we summarize current methodologies obtaining various discuss how delivered via different bolster immunity. Additionally, clinical translation perspective, explore challenges opportunities associated with responses smart NP vaccines. We aim review inspire new strategies use advance research
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113824 - 113824
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Nano TransMed, Год журнала: 2023, Номер 2(2-3), С. 100008 - 100008
Опубликована: Сен. 1, 2023
Cancer remains a formidable health challenge due to the limitations and toxic side effects associated with conventional treatment approaches. Recent research in field of tumor microbiota has revealed significant role bacteria play within tumors. The unique characteristics position them as potential carriers for anticancer therapies. This is their ability accumulate tissues, target blood-brain barrier, thrive hypoxic environments. Meanwhile, exploration microenvironment gained momentum, targeting key intratumoral becoming central focus cancer therapy. Moreover, multifunctional nanoparticles are increasingly prominent strategies. attributed excellent biocompatibility, customizable properties, precise capabilities. These not only being more widely adopted but also maturing application, positioning an optimal choice treatment. article offers overview strategies that utilize deliver nanodrugs targeted It delves into advantages these designing intelligent drug delivery systems. Emphasizing impact tumor's internal bacterial environment on cancer, focuses utilization tumor-associated effective findings presented carry practical value provide reference development innovative therapies based bacteria.
Язык: Английский
Процитировано
8