Designing biomimetic scaffolds for skin tissue engineering

Biomaterials Science, Год журнала: 2023, Номер 11(9), С. 3051 - 3076

Опубликована: Янв. 1, 2023

This review offers systematic considerations of material design principles and fabrication techniques for biomimetic skin tissue engineering scaffolds.

Язык: Английский

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Developing fibrin-based biomaterials/scaffolds in tissue engineering

Bioactive Materials, Год журнала: 2024, Номер 40, С. 597 - 623

Опубликована: Авг. 15, 2024

Tissue engineering technology has advanced rapidly in recent years, offering opportunities to construct biologically active tissues or organ substitutes repair even enhance the functions of diseased and organs. Tissue-engineered scaffolds rebuild extracellular microenvironment by mimicking matrix. Fibrin-based possess numerous advantages, including hemostasis, high biocompatibility, good degradability. Fibrin provide an initial matrix that facilitates cell migration, differentiation, proliferation, adhesion, also play a critical role cell-matrix interactions. are now widely recognized as key component tissue engineering, where they can facilitate defect repair. This review introduces properties fibrin, its composition, structure, biology. In addition, modification cross-linking modes fibrin discussed, along with various forms commonly used engineering. We describe biofunctionalization fibrin. provides detailed overview use applications skin, bone, nervous tissues, novel insights into future research directions for clinical treatment.

Язык: Английский

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Advancements in tissue engineering for cardiovascular health: a biomedical engineering perspective

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Май 31, 2024

Myocardial infarction (MI) stands as a prominent contributor to global cardiovascular disease (CVD) mortality rates. Acute MI (AMI) can result in the loss of large number cardiomyocytes (CMs), which adult heart struggles replenish due its limited regenerative capacity. Consequently, this deficit CMs often precipitates severe complications such failure (HF), with whole transplantation remaining sole definitive treatment option, albeit constrained by inherent limitations. In response these challenges, integration bio-functional materials within cardiac tissue engineering has emerged groundbreaking approach significant potential for replacement. Bioengineering strategies entail fortifying or substituting biological tissues through orchestrated interplay cells, methodologies, and innovative materials. Biomaterial scaffolds, crucial paradigm, provide essential microenvironment conducive assembly functional encapsulating contracting cells. Indeed, field witnessed remarkable strides, largely owing application biomaterial scaffolds. However, complexities persist, necessitating further exploration innovation. This review delves into pivotal role scaffolds engineering, shedding light on their utilization, challenges encountered, promising avenues future advancement. By critically examining current landscape, we aim catalyze progress toward more effective solutions regeneration ultimately, improved outcomes patients grappling ailments.

Язык: Английский

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Extracellular Matrix‐Bioinspired Anisotropic Topographical Cues of Electrospun Nanofibers: A Strategy of Wound Healing through Macrophage Polarization

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(12)

Опубликована: Янв. 31, 2024

Abstract The skin serves as the body's outermost barrier and is largest organ, providing protection not only to body but also various internal organs. Owing continuous exposure external factors, it susceptible damage that can range from simple severe, including serious types of wounds such burns or chronic wounds. Macrophages play a crucial role in entire wound‐healing process contribute significantly regeneration. Initially, M1 macrophages infiltrate phagocytose bacteria, debris, dead cells fresh As tissue repair activated, M2 are promoted, reducing inflammation facilitating restoration dermis epidermis regenerate tissue. This suggests extracellular matrix (ECM) promotes cell adhesion, proliferation, migrationand macrophage polarization. Among numerous strategies, electrospinning versatile technique for obtaining ECM‐mimicking structures with anisotropic isotropic topologies micro/nanofibers. Various electrospun biomaterials influence polarization based on their topologies. Moreover, these fibers possess high surface‐area‐to‐volume ratio, promoting effective exchange vital nutrients oxygen, which viability Micro/nanofibers diverse physical chemical properties be tailored polarize toward regeneration wound healing, depending specific requirements. review describes significance micro/nanostructures activating healing.

Язык: Английский

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Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Nanomaterials, Год журнала: 2024, Номер 14(6), С. 531 - 531

Опубликована: Март 16, 2024

Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic adds complexity to traditional cell cultivation methods. most commonly used technique involves cultivating cells on flat surface in two-dimensional format due its simplicity. A three-dimensional (3D) provide microenvironment for surrounding cells. There two main techniques obtaining 3D structures based the presence scaffolding. Scaffold-free consist spheroid technologies. Meanwhile, scaffold contain organoids all constructs that various types scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels one extensively studied forms potential culture up 4D bioprinted biomaterials. bioprinting is important create scaffolds. versatility this allows many different inks, mainly hydrogels, as well inorganic substances. Increasing amounts data evidence vast usage engineering personalized medicine, with area application being regeneration skin musculoskeletal systems. Recent papers also indicate increasing vivo tests products which further strengthen importance branch emphasize need extensive research safe humansbiomimetic tissues organs. In review article, we recent advancements field preceded by an overview technologies led development complex type culture.

Язык: Английский

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Recent advances in biomaterials for tissue-engineered constructs: Essential factors and engineering techniques

Materials Today Chemistry, Год журнала: 2024, Номер 37, С. 102016 - 102016

Опубликована: Апрель 1, 2024

Tissue-engineered constructs can replicate the structural and physiological properties of natural tissues. The be designed to address transplantation issues affected by shortage donor tissues organs. One major concerns in tissue engineering is design development structures that improve interaction between materials cells provide an ideal platform for form functional tissue. Several contributing factors need considered fabricate constructs, including biomaterials, biological, topographical, biophysical, morphological either alone or combination. Here, we review application, advancement, future directions these essential designing developing regeneration. In particular, focus on original approaches tools construct parameters engineering.

Язык: Английский

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Carboxymethyl chitosan-based hydrogel-Janus nanofiber scaffolds with unidirectional storage-drainage of biofluid for accelerating full-thickness wound healing

Carbohydrate Polymers, Год журнала: 2024, Номер unknown, С. 121870 - 121870

Опубликована: Янв. 1, 2024

Язык: Английский

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ROS‐Activated Nanohydrogel Scaffolds with Multi‐Factors Controlled Release for Targeted Dual‐Lineage Repair of Osteochondral Defects

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 29, 2025

Abstract Achieving self‐healing for osteochondral defects caused by trauma, aging, or disease remains a significant challenge in clinical practice. It is an effective therapeutic strategy to construct gradient‐biomimetic biomaterials that replicate the hierarchical structure and complex microenvironment of tissues dual‐lineage regeneration both cartilage subchondral bone. Herein, ROS‐activated nanohydrogels composite bilayer scaffolds with multi‐factors controlled release are rationally designed using combination 3D printing gelatin placeholder methods. The resulting nanohydrogel exhibit micro‐nano interconnected porous soft‐hard mechanical strength facilitating culture BMSCs vitro. More importantly, multi‐stage continuous responses anti‐inflammation, chondrogenesis osteogenesis, effectively induced via sequential multi‐factors, including diclofenac sodium (DS), kartogenin (KGN) bone morphogenetic protein 2 (BMP‐2), from scaffolds, thereby improved tissue defect model SD rats. These findings suggest such specific delivery functional factors, provides promising defects.

Язык: Английский

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From Bone To Blood Flow: Tissue Engineering In Orthopedics – A Narrative Review

Orthopedic Reviews, Год журнала: 2025, Номер 17

Опубликована: Март 31, 2025

Musculoskeletal injuries and degenerative conditions necessitate advanced regenerative solutions. Tissue engineering has emerged as a pivotal field in orthopedic care, particularly vascularized bone cartilage regeneration. This narrative review examines the latest advancements vascular tissue engineering, including scaffold design, cell-based techniques, growth factor delivery. A comprehensive literature search was conducted using PubMed, ScienceDirect, Google Scholar, focusing on innovations challenges field. Vascularized grafts (VBGs) outperform non-vascularized counterparts promoting healing integration. Advances materials, such smart scaffolds hybrid biomaterials, enhance osteogenesis angiogenesis. Cellular therapies, utilizing mesenchymal stem cells induced pluripotent cells, synergistically improve vascularization Growth factors like VEGF morphogenic protein (BMP-2), integrated with innovative delivery systems, enable sustained angiogenic stimulation While significant strides have been made, persist achieving full integration replicating native architecture. Innovations technology surgery techniques hold promise for transforming improving patient outcomes.

Язык: Английский

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Bio-inspired and biomimetic composites based on biodegradable polymers for sensing applications with emphasis on early diagnosis of cancer

Chemical Engineering Journal, Год журнала: 2024, Номер 493, С. 152445 - 152445

Опубликована: Май 21, 2024

With the increasing demand for tissue adhesive, soft self-healing, antifouling, biodegradable and biocompatible biosensors, use of biomimetic polymers has paved way development these advanced sensing systems. Especially, have provided new opportunities directions implantable wearable biosensors. In fact, impressive in bio-inspired composites based on led to creation tissue-adhesive biosensors with minimal immune response or biofouling. This review aims cover advances mimetic (natural synthetic) an emphasis state-of-the-art devices composites. It also highlights unique properties such as self-adhesion, enzyme-like activity, antibacterial regenerative etc. Considering high rate cancer world, especially developing countries, a separate section is dedicated biopolymers-based sensors early diagnosis cancer. Finally, outlook current challenges future developments this field presented.

Язык: Английский

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