Engineering Multifunctional Surface Topography to Regulate Multiple Biological Responses

Biomaterials, Год журнала: 2025, Номер unknown, С. 123136 - 123136

Опубликована: Янв. 1, 2025

Язык: Английский

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DNA‐based Precision Tools to Probe and Program Mechanobiology and Organ Engineering

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

DNA nanotechnology represents an innovative discipline that combines with biotechnology. It exploits the distinctive characteristics of deoxyribonucleic acid (DNA) to create nanoscale structures and devices remarkable accuracy functionality. Researchers may complex nanostructures precision specialized functions using DNA's innate stability, adaptability, capacity self-assemble through complementary base-pairing interactions. Integrating multiple disciplines, known as nanobiotechnology, allows production sophisticated nanodevices a broad range applications. These include precise drug delivery systems, extremely sensitive biosensors, construction intricate tissue scaffolds for regenerative medicine. Moreover, combining mechanobiology provides new understanding how small-scale mechanical stresses molecular interactions affect cellular activity development. has potential revolutionize diagnostics, engineering, organ regeneration. This could lead enormous improvements in biomedicine. review emphasizes most recent developments nanotechnology, explicitly highlighting its significant influence on growing involvement engineering. extensive overview present trends, obstacles, future prospects this fast-progressing area.

Язык: Английский

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Understanding the Degradation and Mechanical Performance of Hyperelastic Polylactide Copolymers through Bulk and Ultrathin Film Analysis Correlation

Polymer Degradation and Stability, Год журнала: 2025, Номер unknown, С. 111267 - 111267

Опубликована: Фев. 1, 2025

Язык: Английский

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Effect of Crosslinking Agent on the Cellulose Nanocrystals Reinforced Hydroxyethyl Cellulose/Poly(Vinyl Alcohol) Scaffolds

Macromolecular Symposia, Год журнала: 2025, Номер 414(1)

Опубликована: Фев. 1, 2025

Abstract The aim of this study is to analyze the effect crosslinking agent on blend bioplolymerized hydroxyethyl cellulose and poly(vinyl alcohol) (PVA) with nanocrystal porous scaffolds. cellulose/PVA/crystal nanocellulose (HEC/PVA/CNC) crosslinked by using two different polymer solutions which are glutaraldehyde (GA) (1 wt.%) calcium chloride (20 wt.%). comparison physicochemical properties scaffolds characterized via field electron scanning microscope (FESEM), Fourier transform infrared (FTIR), TGA, degradation, mechanical studies. results show that fabricated improved process more prominent GA organic compound. Overall, HEC/PVA/CNC exhibited good can be considered as potential substrate for tissue engineering applications.

Язык: Английский

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PVA/Gelatin/Cnidium monnieri Composite Scaffolds for Atopic Dermatitis Skin Tissue Regeneration

Gels, Год журнала: 2025, Номер 11(2), С. 143 - 143

Опубликована: Фев. 18, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by impaired barrier function and persistent inflammation, necessitating advanced therapeutic solutions. This study presents the development of novel composite hydrogel scaffold composed polyvinyl alcohol (PVA), gelatin, Cnidium monnieri (CM) extract, designed to address dual challenges tissue regeneration inflammation suppression. Fabricated via optimized freeze-thaw crosslinking lyophilization, exhibited highly porous structure conducive enhanced cell proliferation controlled bioactive release. FT-IR analysis confirmed robust intermolecular interactions among PVA, CM bioactives, while SEM imaging revealed well-developed network. The UPLC demonstrated sustained release key compounds, such as osthole imperatorin, which contributed scaffold's anti-inflammatory properties. Biological assessments using HaCaT keratinocytes under conditions induced TNF-α IFN-γ improved viability significant suppression IL-8 expression, critical marker in AD-related inflammation. These findings underscore potential PVA/Gel/CM an platform for disorders.

Язык: Английский

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Enhancing calcium phosphate cements: A review of bacterial cellulose (BC) and other biopolymer reinforcements for biomedical applications

Biomaterials Advances, Год журнала: 2025, Номер 172, С. 214245 - 214245

Опубликована: Фев. 27, 2025

Язык: Английский

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Bone regenerative medicine: An emerging field with opportunities and challenges

Journal of the American Ceramic Society, Год журнала: 2025, Номер unknown

Опубликована: Март 22, 2025

Abstract The global prevalence of bone disorders has significantly increased and is projected to double by 2024. In many instances, addressing defects requires extensive surgical procedures, including grafting techniques that often result in prolonged healing times, a heightened risk infection, considerable pain, with no assurance complete recovery. Bone tissue engineering (BTE) scaffolds are emerging as promising alternative conventional due their abundant availability absence disease transmission. primary aim BTE encourage the regeneration functional through synergistic approach combines biomaterials, cells, therapeutic factors. One major challenge this field ensuring proper integration implanted biomaterials host promoting vascularization provide adequate nutrients newly formed tissue. Additionally, factors such biodegradability, biocompatibility, bioactivity, cost‐effectiveness 3D porous still not optimal. This review discusses basics highlights current landscape field, focusing on existing technological clinical opportunities challenges. Furthermore, it aims illustrate advancements using various construction materials recent scientific findings area.

Язык: Английский

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Poly(L-lactide)/Nano-hydroxyapatite Piezoelectric Scaffolds for Tissue Engineering

Micron, Год журнала: 2024, Номер 188, С. 103743 - 103743

Опубликована: Ноя. 8, 2024

Язык: Английский

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Insights into the fabrication of microchannels on biomedical NiTinol

CIRP journal of manufacturing science and technology, Год журнала: 2024, Номер 56, С. 106 - 118

Опубликована: Дек. 19, 2024

Язык: Английский

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Advances in Mesenchymal Stem Cell Therapy and Natural Antioxidants for Hepatic Fibrosis: A Comprehensive Review

Deleted Journal, Год журнала: 2024, Номер 2, С. 100016 - 100016

Опубликована: Март 1, 2024

Liver damage resulting from the administration of various allopathic drugs and their associated toxicity has become a major health problem, leading to hepatic fibrosis, cirrhosis, metabolic disorders. This epidemic condition liver disease represents global cause death morbidity. Although orthotopic transplantation remains vital treatment option for fibrotic conditions, its efficacy is limited by organ scarcity risk immunological rejection. Consequently, alternative therapeutic approaches are urgently needed. Cell-based therapy utilizing mesenchymal stem cells (MSCs) garnered considerable interest as promising modality. MSCs exhibit immunomodulatory properties can differentiate into hepatocytes, thus facilitating regeneration damaged hepatocytes increasing residual hepatocyte proliferation while inhibiting activation or apoptosis stellate cells. However, despite potential benefits, transplanted often low survival rates due inadequate oxidative inflammatory stress resistance. Plants harbor diverse array bioactive compounds known possess hepatoprotective antioxidant properties. Nanomaterials play crucial role in regenerative medicine providing targeted delivery agents scaffolds tissue engineering. In treating liver, nanomaterials help mitigate fibrosis progression promote through controlled release anti-fibrotic growth factors. review highlights synergistic cell-based therapy, natural antioxidants, differentiation factors, nanotechnology combating advancing medicine. These combined offer avenues effectively conditions promoting regeneration.

Язык: Английский

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