Nanomaterials, Год журнала: 2024, Номер 14(24), С. 2028 - 2028
Опубликована: Дек. 17, 2024
Advancing experimental methodologies to accurately replicate the physiological and pathological characteristics of biological tissues is pivotal in tissue engineering [...]
Язык: Английский
Process Biochemistry, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
15
Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(10), С. 280 - 280
Опубликована: Сен. 25, 2024
Bone tissue regeneration is a rapidly evolving field aimed at the development of biocompatible materials and devices, such as scaffolds, to treat diseased damaged osseous tissue. Functional scaffolds maintain structural integrity provide mechanical support defect site during healing process, while simultaneously enabling or improving through amplified cellular cues between scaffold native tissues. Ample research on functionalization has been conducted improve scaffold–host interaction, including fabrication techniques, biomaterial selection, surface modifications, integration bioactive molecular additives, post-processing modifications. Each these methods plays crucial role in not only but actively participate process bone joint surgery. This review provides state-of-the-art, comprehensive overview scaffold-based strategies used engineering, specifically for regeneration. Critical issues obstacles are highlighted, applications advances described, future directions identified.
Язык: Английский
Процитировано
14
Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(9), С. 241 - 241
Опубликована: Авг. 23, 2024
The rising demand for effective bone regeneration has underscored the limitations of traditional methods like autografts and allografts, including donor site morbidity insufficient biological signaling. This review examines nanoparticles (NPs) in tissue engineering (TE) to address these challenges, evaluating polymers, metals, ceramics, composites their potential enhance osteogenesis angiogenesis by mimicking extracellular matrix (ECM) nanostructure. involved synthesizing characterizing nanoparticle-based scaffoldsand integrating hydroxyapatite (HAp) with polymers mechanical properties osteogenic potential. results showed that NPs significantly promote cell growth, differentiation, formation, carbon-based graphene carbon nanotubes showing promise. offer versatile, biocompatible, customizable scaffolds drug delivery support repair. Despite promising results, challenges cytotoxicity, biodistribution, immune responses remain. Addressing issues through surface modifications biocompatible molecules can improve biocompatibility efficacy nanomaterials. Future research should focus on long-term vivo studies assess safety NP-based explore synergistic effects other bioactive or growth factors. underscores transformative advancing BTE calls further optimize technologies clinical applications.
Язык: Английский
Процитировано
11
Computation, Год журнала: 2024, Номер 12(4), С. 74 - 74
Опубликована: Апрель 4, 2024
Three-dimensional porous scaffolds are substitutes for traditional bone grafts in tissue engineering (BTE) applications to restore and treat injuries defects. The use of computational modelling is gaining momentum predict the parameters involved healing cell seeding procedures perfusion bioreactors reach final goal optimal growth. Computational based on finite element method (FEM) fluid dynamics (CFD) two standard methodologies utilised investigate equivalent mechanical properties scaffolds, as well flow characteristics inside respectively. success a simulation hinges selection relevant mathematical model with proper initial boundary conditions. This review paper aims provide insights researchers regarding appropriate (FE) models different materials CFD regimes bioreactors. Thus, these FEM/CFD may help create efficient designs by predicting their structural haemodynamic responses prior vitro vivo (TE) applications.
Язык: Английский
Процитировано
5
Transplant International, Год журнала: 2024, Номер 37
Опубликована: Окт. 14, 2024
The field of organ transplantation is experiencing a transformative shift with the rise Advanced Therapy Medicinal Products (ATMPs), which include gene therapies, somatic cell and tissue-engineered products. These therapies offer new, potentially curative treatments for longstanding medical challenges, impacting numerous patients. However, their adoption hindered by complex regulatory frameworks, high production costs, inconsistent access across Europe. ESOT ATMP Task Force’s position paper analyzes these challenges from research to clinical application, advocating coordinated strategy Europe as leader in development. It proposes specific actions such streamlining pathways accelerate approvals, boosting funding research, creating specialized facilities development implementation. also highlights critical roles patient engagement real-world evidence optimizing practices.
Язык: Английский
Процитировано
4
Advances in experimental medicine and biology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
The development of bioink-based 3D-printed scaffolds has revolutionized bone tissue engineering (BTE) by enabling patient-specific and biomimetic constructs for regeneration.
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 186, С. 118036 - 118036
Опубликована: Апрель 8, 2025
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Biomimetics, Год журнала: 2024, Номер 9(7), С. 397 - 397
Опубликована: Июнь 30, 2024
Aerogels are lightweight and highly porous materials that have been found to great potential in biomedical research because of some their unique properties, such as high surface area, tunable porosity, biocompatibility. Researchers exploring ways use aerogels create biomimetic scaffolds inspired by natural extracellular matrices (ECMs) for various applications. Aerogel can serve three-dimensional (3D) templates cell growth tissue regeneration, promoting wound healing repair. Additionally, aerogel-based controlled drug delivery systems, where area porosity enable the efficient loading release therapeutic agents. In this review, we discuss biopolymer-based aerogel engineering, delivery, biosensors. Finally, also directions development scaffolds.
Язык: Английский
Процитировано
3