ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(5), С. 5628 - 5636
Опубликована: Фев. 22, 2024
The
theophylline
derivative
d17
is
a
candidate
drug
for
nonsmall
cell
lung
cancer
(NSCLC)
treatment
previously
developed
by
our
group.
However,
it
has
the
limitations
of
inadequate
bioavailability,
poor
targeting,
and
insignificant
therapeutic
effect.
Chemo-photodynamic
synergistic
therapy
promising
method
antitumor
therapy.
Herein,
photosensitizer
chlorin
e6
(Ce6)
were
loaded
into
nanoparticles
(NPs)
via
supramolecular
self-assembly,
which
are
self-assembled
through
π–π
stacking
hydrogen
bond
interactions
to
form
nanospheres
with
size
about
85
nm
surface
charge
−33
mV.
Compared
free
Ce6,
d17–Ce6
NPs
have
good
hydrophilicity
stability
can
effectively
accumulate
in
NSCLC
tumor
tissues
due
enhancement
retention
More
significantly,
synergistically
inhibit
growth
compared
other
groups
no
obvious
toxicity.
Taken
together,
may
be
an
effective
carrier-free
nanodrug
chemo-photodynamic
NSCLC.
Molecules,
Год журнала:
2023,
Номер
28(15), С. 5905 - 5905
Опубликована: Авг. 5, 2023
Cancer
is
a
progressive
disease
of
multi-factorial
origin
that
has
risen
worldwide,
probably
due
to
changes
in
lifestyle,
food
intake,
and
environmental
as
some
the
reasons.
Skin
cancer
can
be
classified
into
melanomas
from
melanocytes
nonmelanoma
skin
(NMSC)
epidermally-derived
cell.
Together
it
constitutes
about
95%
cancer.
Basal
cell
carcinoma
(BCC)
cutaneous
squamous
(CSCC)
are
creditworthy
99%
NMSC
limited
accessibility
conventional
formulations
cells
having
multiple
obstacles
treatment
reply
this
therapeutic
regime.
Despite
this,
often
encounters
erratic
bioavailability
absorption
target.
Nanoparticles
developed
through
nanotechnology
platforms
could
better
topical
therapy
option.
To
improve
delivery,
nano-sized
delivery
system
appropriate
fuses
with
layer
fluidized
membrane;
thus,
deeper
penetration
therapeutics
possible
reach
target
spot.
This
review
briefly
outlooks
various
nanoparticle
preparations,
i.e.,
liposomes,
niosomes,
ethosomes,
transferosomes,
transethosomes,
nanoemulsions,
nanoparticles
technologies
tested
impede
their
progress
tend
concentrate
layers.
Nanocarriers
have
proved
they
considerably
boost
medication
bioavailability,
lowering
frequency
dosage
reducing
toxicity
associated
high
doses
medication.
Abstract
Nowadays,
cancer
has
become
the
leading
cause
of
death
worldwide,
driving
need
for
effective
therapeutics
to
improve
patient
prognosis.
Photodynamic
therapy
(PDT)
been
widely
applied
as
an
antitumor
modality,
owing
its
minimal
invasiveness,
localized
tumor
damage,
and
high
safety
profile.
However,
efficacy
is
limited
by
poor
stability
photosensitizers,
inadequate
accumulation,
a
complex
microenvironment.
To
overcome
these
challenges,
extensive
endeavors
have
made
explore
co‐assembly
used
photosensitizer
chlorin
e6
(Ce6)
with
various
functional
small
molecules
enhance
pharmacodynamic
activity.
This
review
provides
comprehensive
overview
current
studies
on
Ce6‐based
nanoparticles
PDT
precise
delivery
molecules.
The
self‐assembly
mechanism
will
be
discussed
in
detail,
focus
potential
strategies
combinational
PDT.
Abstract
Photodynamic
therapy
(PDT)
has
recently
been
considered
a
potential
tumor
due
to
its
time‐space
specificity
and
non‐invasive
advantages.
PDT
can
not
only
directly
kill
cells
by
using
cytotoxic
reactive
oxygen
species
but
also
induce
an
anti‐tumor
immune
response
causing
immunogenic
cell
death
of
cells.
Although
it
exhibits
promising
prospect
in
treating
tumors,
there
are
still
many
problems
be
solved
practical
application.
Tumor
hypoxia
immunosuppressive
microenvironment
seriously
affect
the
efficacy
PDT.
The
hypoxic
is
mainly
abnormal
vascular
matrix
around
tumor,
metabolism,
influence
various
immunosuppressive‐related
their
expressed
molecules.
Thus,
reprogramming
(TME)
great
significance
for
rejuvenating
This
article
reviews
latest
strategies
PDT,
from
regulating
matrix,
interfering
with
related
factors
reverse
microenvironment.
These
provide
valuable
information
better
understanding
TME
guide
development
next‐generation
multifunctional
nanoplatforms
Pharmacological Research,
Год журнала:
2024,
Номер
203, С. 107150 - 107150
Опубликована: Март 21, 2024
Cancer,
with
its
diversity,
heterogeneity,
and
complexity,
is
a
significant
contributor
to
global
morbidity,
disability,
mortality,
highlighting
the
necessity
for
transformative
treatment
approaches.
Photodynamic
therapy
(PDT)
has
aroused
continuous
interest
as
viable
alternative
conventional
cancer
treatments
that
encounter
drug
resistance.
Nanotechnology
brought
new
advances
in
medicine
shown
great
potential
delivery
treatment.
For
precise
efficient
therapeutic
utilization
of
such
tumor
approach
high
spatiotemporal
selectivity
minimal
invasiveness,
carrier-free
noncovalent
nanoparticles
(NPs)
based
on
chemo-photodynamic
combination
essential.
Utilizing
natural
products
foundation
nanodrug
development
offers
unparalleled
advantages,
including
exceptional
pharmacological
activity,
easy
functionalization/modification,
well
biocompatibility.
The
natural-product-based,
carrier-free,
NPs
revealed
excellent
synergistic
anticancer
activity
comparison
free
photosensitizers
bioactive
products,
representing
an
favorable
avenue
improve
efficacy.
Herein,
comprehensive
summary
current
strategies
representative
application
examples
past
decade
(such
paclitaxel,
10-hydroxycamptothecin,
doxorubicin,
etoposide,
combretastatin
A4,
epigallocatechin
gallate,
curcumin)
therapy.
We
highlight
insightful
design
synthesis
smart
aim
enhance
PDT
Meanwhile,
we
discuss
future
challenges
opportunities
associated
these
provide
enlightenment,
spur
innovative
ideas,
facilitate
PDT-mediated
clinical
transformation.
Abstract
The
poor
prognosis
of
triple‐negative
breast
cancer
(TNBC)
results
from
its
high
metastasis,
whereas
inflammation
accompanied
by
excessive
reactive
oxygen
species
(ROS)
is
prone
to
aggravate
tumor
metastasis.
Although
photothermal
therapy
(PTT)
has
extremely
therapeutic
efficiency,
the
crafty
cells
allow
an
increase
in
expression
heat
shock
proteins
(HSPs)
limit
effect,
and
PTT‐induced
also
thought
be
a
potential
trigger
for
Herein,
myricetin,
iron
ions,
polyvinylpyrrolidone
were
utilized
develop
nanomedicines
self‐assembly
strategy
treatment
metastatic
TNBC.
with
marvelous
water
solubility
dispersion
can
inhibit
glucose
transporter
1
interfere
mitochondrial
function
block
energy
supply
cells,
achieving
starvation
on
TNBC
cells.
Nanomedicines
excellent
conversion
properties
down‐regulating
HSPs
enhance
effect
PTT.
Interestingly,
broad
spectrum
ROS
scavenging
ability
successfully
attenuates
as
well
influences
hypoxia‐inducible
factors‐1α/3‐phosphoinositide‐dependent
protein
kinase
related
pathway
through
glycometabolism
inhibition
reduce
cell
Moreover,
have
negligible
side
effects
good
clinical
application
prospects,
which
provides
valuable
paradigm
interference,
anti‐inflammation,
starvation,
synergistic
therapy.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(26), С. 6285 - 6304
Опубликована: Янв. 1, 2024
Phototherapy,
including
photothermal
therapy
(PTT)
and
photodynamic
(PDT),
has
the
advantages
of
spatiotemporal
selectivity,
non-invasiveness,
negligible
drug
resistance.
Phototherapy
been
approved
for
treating
superficial
epidermal
tumors.
However,
its
therapeutic
efficacy
is
limited
by
hypoxic
tumor
microenvironment
highly
expressed
heat
shock
protein.
Moreover,
poor
tissue
penetration
focused
irradiation
laser
region
in
phototherapy
make
deep
tissues
metastatic
tumors
challenging.
Combination
strategies,
which
integrate
each
treatment
overcome
their
disadvantages,
can
significantly
improve
efficacy.
Recently,
many
combination
strategies
have
reported.
Our
study
summarizes
used
combining
with
other
cancer
treatments
such
as
chemotherapy,
immunotherapy,
sonodynamic
therapy,
gas
starvation
chemodynamic
therapy.
Some
research
cases
were
selected
to
analyze
effect,
delivery
platform
feature,
synergetic
anticancer
mechanisms.
additional
are
summarized
tables.
This
review
provides
strong
evidence
that
phototherapy-based
enhance
effect
compared
alone.
Additionally,
challenges
future
perspectives
associated
these
combinational
therapies
discussed.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 5, 2024
Abstract
Utilizing
enzyme
cascades
as
a
promising
approach
for
targeted
cancer
therapies
holds
significant
potential,
yet
its
clinical
effectiveness
is
substantially
hindered
by
functional
losses
during
delivery.
Complex
coacervation
emerges
an
intriguing
strategy
designing
nanoreactors.
In
this
study,
noteworthy
achievement
presented
in
the
development
of
lactobionic
acid‐modified
tumor
microenvironment
(TME)‐responsive
polyelectrolyte
complex
vesicles
(HGS‐PCVs)
based
on
bioinspired
homopolypeptoids,
which
serve
facile,
intelligent,
and
highly
efficient
nanoreactor
tunable
glucose
oxidase,
hemoglobin,
sorafenib
(SRF)
to
hepatic
cells.
The
TME‐responsive
permeability
HGS‐PCVs
enables
selective
entry
into
their
interior,
triggering
enzymatic
cascade
reaction
within
tumor.
This
intricate
process
generates
toxic
hydroxyl
radicals
while
concurrently
lowering
pH.
Consequently,
pH
shift
enhances
SRF
release,
effectively
promoting
ferroptosis
apoptosis
target
Further,
administration
not
only
initiates
immunogenic
cell
death
but
also
plays
crucial
role
inducing
maturation
dendritic
cells
lymph
nodes.
It
stimulates
adaptive
T‐cell
response,
mechanism
that
contributes
impeding
growth
distant
tumors
vivo,
demonstrating
potential
PCVs
immunotherapy.
