Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(13)
Опубликована: Фев. 9, 2024
Aggregation-induced
emission
luminogens
(AIEgens)
are
promising
photosensitizers
that
have
exhibited
excellent
antibacterial
ability
with
abundant
reactive
oxygen
species
(ROS)
generation.
TTCPy-PF6
and
TTCPy-Br
deposited
on
the
surface
of
diverse
solid
substrates
through
plasma-assistant
electrostatic
self-assembly.
The
AIEgens-covered
coating
can
effectively
eliminate
different
pathogenic
Gram-positive
(G+)
bacteria
even
their
multidrug-resistant
(MDR)
mutants
negligible
side
effects
such
as
cytotoxicity,
hemolysis,
inflammation.
Moreover,
AIEgen-coated
maintain
high
stability
for
long-time
usage,
which
is
dependent
ROS-mediated
disruption
attached
bacteria.
AIEgen-based
coatings
broad
applicability
many
advantages
in
ability,
great
biocompatibility,
low
possibility
antibiotic
pollution.
robust
biological
safety
would
be
helpful
disinfection
medical
devices.
Accounts of Materials Research,
Год журнала:
2023,
Номер
4(7), С. 627 - 640
Опубликована: Июнь 21, 2023
ConspectusBioadhesives
are
important
for
the
future
of
medicine
in
their
roles
wound
closure
and
as
measures
to
enhance
healing.
These
adhesives
more
effective
less
invasive
than
conventional
methods,
such
surgical
sutures
or
staples.
Adhesive
substances
based
on
naturally
occurring
biological
materials
from
living
organisms
harness
phenolic
compounds
attachment
wet
surfaces.
For
example,
plants,
Boston
ivy,
animals,
mussels,
have
evolved
tissues
that
create
optimal
adhesion
under
a
variety
challenging
conditions,
including
aqueous
saline
environments.
Current
research
aims
at
using
biomimetic
strategies
new
generation
bioadhesives
will
be
better
suited
medical
use.
Biomaterials
design
has
around
integration
phenols
with
protein
backbones
among
which
gelatin
received
particular
attention
due
its
excellent
bioactivity,
biocompatibility,
biodegradability,
low
cost,
facile
chemical
tunability,
tissue-mimetic
properties.
Bioadhesion
performance
these
biomaterials
is
strong
function
polyphenolic
functionality
processing
approach
into
hydrogel
networks.
A
number
studies
used
small
molecules
modify
biomacromolecules
chemically
bioadhesion.
One
major
hurdles
insufficient
uptake
low-yield
modification
chemistries
inherently
limited
functionalization
capacity
proteins.
Polyphenols
an
attractive
toolbox
bioadhesive
design,
they
not
only
enable
stronger
interactions
various
substrates
but
also
act
cross-linking
points,
strengthening
polymer
network
cohesion.
In
addition,
mechanism
gelation
should
compatible
moieties,
as,
instance,
free-radical
polymerization
presence
compromised
by
scavenging
effects.
Polyphenolic
derived
synthetically
well
those
naturally,
tannins,
added
large
library
additional
functionality,
antimicrobial
photothermal
responsiveness,
calling
further
developments
applications
management.In
this
Account,
we
review
several
recent
breakthroughs
polyphenol-integrated
been
analyzed
context
use
bioadhesives.
play
covalent
noncovalent
functional
groups
substrates,
keratins,
connective
tissue,
soft
internal
tissues.
We
consider
different
polyphenol-carrying
catecholamines,
amino
acids,
lignins.
then
discuss
how
can
fabricated
mimic
through
infusion,
physical
mixing,
copolymerization.
implications
bioadhesives,
questioning
viability
prospects.
Finally,
highlight
current
challenges
opportunities
taking
closer
clinical
translation.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(13)
Опубликована: Фев. 9, 2024
Aggregation-induced
emission
luminogens
(AIEgens)
are
promising
photosensitizers
that
have
exhibited
excellent
antibacterial
ability
with
abundant
reactive
oxygen
species
(ROS)
generation.
TTCPy-PF6
and
TTCPy-Br
deposited
on
the
surface
of
diverse
solid
substrates
through
plasma-assistant
electrostatic
self-assembly.
The
AIEgens-covered
coating
can
effectively
eliminate
different
pathogenic
Gram-positive
(G+)
bacteria
even
their
multidrug-resistant
(MDR)
mutants
negligible
side
effects
such
as
cytotoxicity,
hemolysis,
inflammation.
Moreover,
AIEgen-coated
maintain
high
stability
for
long-time
usage,
which
is
dependent
ROS-mediated
disruption
attached
bacteria.
AIEgen-based
coatings
broad
applicability
many
advantages
in
ability,
great
biocompatibility,
low
possibility
antibiotic
pollution.
robust
biological
safety
would
be
helpful
disinfection
medical
devices.
