MedComm – Biomaterials and Applications,
Год журнала:
2024,
Номер
3(4)
Опубликована: Ноя. 10, 2024
Abstract
The
effective
treatment
of
skin
wounds
has
long
posed
a
significant
challenge
in
the
medical
field,
impacting
patient
comfort,
quality
life,
and
rate
outcome
wound
healing.
With
continuous
advancements
science
technology,
novel
materials
have
emerged,
providing
new
possibilities
for
treatment.
Among
these,
multifunctional
hydrogels
shown
considerable
potential
promoting
healing
as
type
dressing
material.
This
review
systematically
examines
progress
application
Initially,
structure
composition
are
introduced.
Subsequently,
classified,
wound‐healing
process
is
discussed
detail.
Traditional
modern
dressings
then
categorized,
with
particular
emphasis
on
characteristics
applications
hydrogel
dressings.
various
functions
healing,
including
antibacterial,
antioxidant,
hemostatic,
adhesive,
stimulus‐responsive,
status
monitoring,
reviewed.
paper
concludes
summary
existing
research
gaps
provides
insights
into
future
development
directions
hydrogels.
aims
to
guide
preparation
offer
theoretical
references
exploration
next‐generation
functional
Gels,
Год журнала:
2025,
Номер
11(2), С. 123 - 123
Опубликована: Фев. 7, 2025
Recent
advancements
in
wound
dressing
materials
have
significantly
improved
acute
and
chronic
management
by
addressing
challenges
such
as
infection
control,
moisture
balance,
enhanced
healing.
Important
progress
has
been
made,
especially
with
hydrogels,
foams,
antimicrobial
for
creating
optimized
dressings.
Hydrogels
are
known
maintaining
optimal
levels,
while
foam
dressings
excellent
exudate
absorbents.
Meanwhile,
incorporates
various
agents
to
reduce
risks.
These
options
healing
time
focusing
on
customized
patient
needs.
Therefore,
this
review
highlights
the
newest
research
prototypes
applications,
emphasizing
their
particular
benefits
clinical
importance.
Innovations
stimuli-responsive
hydrogels
hybrid
bioengineered
composites
discussed
relation
properties,
including
responsiveness
pH,
temperature,
glucose,
or
enzymes
drug
delivery
precision.
Moreover,
ongoing
trials
included,
demonstrating
potential
of
emerging
solutions
be
soon
translated
from
laboratory
settings.
By
discussing
interdisciplinary
approaches
that
integrate
advanced
materials,
nanotechnology,
biological
insights,
work
provides
a
contemporary
framework
patient-centric,
efficient
care
strategies.
Precision medicine and engineering.,
Год журнала:
2024,
Номер
1(1), С. 100001 - 100001
Опубликована: Июль 28, 2024
Stimulus-responsive
hydrogels
can
undergo
controllable
shape
deformation
and
exhibit
sol-gel
transition
behavior
under
stimulus
signals
such
as
pH,
reactive
oxygen
species
(ROS),
heat,
light.
Polysaccharides
have
become
ideal
candidates
for
constructing
stimulus-responsive
due
to
their
biocompatibility
biodegradability.
The
diversity
of
molecular
weights
functional
groups
polysaccharides
allows
them
self-assemble
or
cooperate
with
other
materials
obtain
through
physical
chemical
crosslinking.
Bioactive
ingredients
nanomaterials
be
conveniently
encapsulated
in
the
hydrogel
matrix
meet
various
requirements.
polysaccharide-based
are
widely
used
biomedical
field,
especially
fields
drug
delivery,
tissue
engineering,
biosensors,
imaging.
In
this
review,
design
strategies
recent
research
advances
stimuli-responsive
summarized.
Future
challenges
also
presented,
review
will
guide
study
polysaccharide
hydrogels.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101635 - 101635
Опубликована: Март 5, 2025
Magnesium-related
bone
implants
have
garnered
significant
attention
in
the
treatment
of
defects.
The
applications
magnesium
promoting
repair
mainly
include
degradable
magnesium-based
scaffolds
owing
to
its
special
physical
properties
and
composite
materials
modified
by
ions
because
biological
activity.
Although
numerous
studies
confirmed
unique
application
advantages
efficacy
repair,
some
obvious
shortcomings
persist,
including
rapid
degradation
scaffolds.
In
this
review,
deficiencies
alloys
construction
orthopedic
their
key
influencing
factors
were
summarized;
furthermore,
advanced
improvement
schemes
summarized
analyzed.
Additionally,
strategies
magnesium-modified
are
discussed.
Lastly,
review
incorporates
latest
research
discoveries
on
science,
comprehensively
exploring
mechanism
magnesium's
role
complex
microenvironment
defects
from
multiple
dimensions.
This
paper
provides
a
comprehensive
summary
analysis
cutting-edge
concepts
design
development
implants,
considering
various
perspectives
such
as
functions
magnesium.
Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 731 - 731
Опубликована: Март 17, 2025
Additive
manufacturing,
also
known
as
3D
printing,
is
becoming
more
and
popular
because
of
its
wide
range
materials
flexibility
in
design.
Layer
by
layer,
complex
structures
can
be
generated
the
revolutionary
computer-aided
process
bioprinting.
It
particularly
crucial
for
youngsters
elderly
patients
a
useful
tool
tailored
pharmaceutical
therapy.
A
lot
research
has
been
carried
out
recently
on
use
polysaccharides
matrices
tissue
engineering
medication
delivery.
Still,
there
great
need
to
create
affordable,
sustainable
bioink
with
high-quality
mechanical,
viscoelastic,
thermal
properties
well
biocompatibility
biodegradability.
The
primary
biological
substances
(biopolymers)
chosen
formulation
are
proteins
polysaccharides,
among
several
resources
utilized
creation
such
structures.
These
naturally
occurring
biomaterials
give
macromolecular
structure
mechanical
qualities
(biomimicry),
generally
compatible
tissues
cells
(biocompatibility),
harmonious
digesting
processes
(biodegradability).
However,
difficulty
cell-laden
printing
technique
(bioprinting)
rheological
characteristics
these
natural-based
bioinks.
Polysaccharides
widely
used
they
abundant
reasonably
priced
natural
polymers.
Additionally,
serve
excipients
formulations
pharmaceuticals,
nutraceuticals,
cosmetics.
remarkable
benefits
polysaccharides—biocompatibility,
biodegradability,
safety,
non-immunogenicity,
absence
secondary
pollution—make
them
ideal
substrates.
purpose
this
publication
examine
recent
developments
challenges
related
stimuli-responsive
site-specific
administration
engineering.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 16, 2025
Abstract
Diabetic
wounds
with
biofilm
present
a
significant
challenge
in
wound
care,
often
leading
to
chronic
inflammation,
recurrent
infections,
impaired
healing,
and
severe
cases,
amputations.
Addressing
this
critical
requires
multifaceted
treatment
strategy.
Herein,
hybrid‐nested
microneedle
scaffold
(MQW‐CMg‐MOF)
designed
for
efficient
removal
is
reported
healing
of
diabetic
accelerated.
This
integrates
as
system:
the
bottom
layer
features
nested
patch
embedded
vancomycin,
antimicrobial
peptide
W379,
angiogenic
QK
peptide,
while
top
consists
chitosan
cryogels
incorporated
magnesium
metal–organic
frameworks.
The
patches
are
engineered
penetrate
mechanically
disrupt
biofilms
enable
programmed
release
agents,
effectively
addressing
infection
promoting
angiogenesis.
Simultaneously,
serve
substrate
scavenging
reactive
oxygen
species
supporting
cell
ingrowth.
show
substantial
vitro
preclinical
swine
biofilm‐infected
model
compared
control.
Most
importantly,
combined
arrays
combat
promote
type
2
(db/db)
mice.
Overall,
multifunctional
hybrid
system
shows
promise
facilitating
enhancing
wounds.
Background:
Traditional
bandages,
gauze,
and
cotton
balls
are
increasingly
insufficient
for
addressing
complex
war
injuries
characterized
by
severe
bleeding
diverse
wound
conditions.
The
giant
salamander,
a
species
of
high
medical
value,
secretes
unique
mucus
when
stimulated,
which
has
potential
applications
in
care.Materials:
Giant
salamander
skin
gel
dressing
wrapped
with
bone
marrow
mesenchymal
stem
cells
(BMSCs-GSSM-gel)
was
prepared
validated.
Skin
injury
rabbit
mouse
models
were
established.
Hematoxylin
Eosin,
Masson's
trichrome,
Sirius
red
staining
performed.
platelet
aggregation
rate
coagulation
items
measured.
Transcriptome
sequencing
performed
to
find
differential
expression
genes.Results:
Preparation
characterization
BMSCs-GSSM-gel
performed,
particles
diameter
about
200
nm
obtained.
accelerated
healing
both
models.
significantly
promoted
hemostasis
via
increasing
fibrinogen,
but
decreasing
activated
partial
thromboplastin
time,
thrombin
prothrombin
time.
treatment
impacted
several
genes
associated
cell
adhesion,
inflammatory
response,
collagen-containing
extracellular
matrix,
the
positive
regulation
migration
based
on
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
analysis.
Integrin
Subunit
Beta
4
(ITGB4),
Alpha
3
(ITGA3),
Laminin
(LAMB3)
might
be
involved
process
BMSCs-GSSM-gel.Conclusions:
We
proved
greatly
improved
healing,
it
play
crucial
role
application
fields
damage
repair.
