Abstract
Microwave
thermotherapy
(MWTT)
has
limited
its
application
in
the
clinic
due
to
high
rate
of
metastasis
and
recurrence
after
treatment.
Nitric
oxide
(NO)
is
a
gaseous
molecule
that
can
address
rates
MWTT
by
increasing
thermal
sensitivity,
down‐regulating
expression
hypoxia‐inducible
factor‐1
(HIF‐1),
inducing
immunogenic
cell
death
(ICD).
Therefore,
GaMOF‐Arg
designed,
gallium‐based
organic
skeleton
material
derivative
loaded
with
L‐arginine
(L‐Arg),
coupled
mitochondria‐targeting
drug
triphenylphosphine
(TPP)
on
surface
obtain
GaMOF‐Arg‐TPP
(GAT)
MW‐immunosensitizers.
When
GAT
MW‐immunosensitizers
are
introduced
into
mice
through
tail
vein,
reactive
oxygen
species
(ROS)
generated
L‐Arg
released
under
MW
action.
Then,
reacts
ROS
generate
NO,
which
not
only
downregulates
HIF‐1
improve
tumor
hypoxia
exacerbated
MW,
but
also
enhances
immune
responses
augment
calreticulin
(CRT)
exposure,
mobility
group
box
1
(HMGB1)
release,
T‐cell
proliferation
achieve
prevention
recurrence.
In
addition,
NO
induce
mitochondria
damage
increase
their
sensitivity
MWTT.
This
study
provides
unique
insight
use
metal‐organic
framework
enhance
therapy
offers
new
way
treat
cancer
efficiently.
Journal of Polymer Science,
Год журнала:
2023,
Номер
62(2), С. 297 - 323
Опубликована: Окт. 20, 2023
Abstract
Polymeric
assemblies
have
emerged
as
a
kind
of
promising
platform
in
biomedical
fields.
The
strong
potency
polyphenols
to
form
versatile
interactions
with
other
small
or
polymeric
molecules
via
covalent
and
noncovalent
linkages
enables
serve
molecular
glues,
offering
magic
driving
force
assemble
multiple
functional
into
diversity
polyphenol‐based
systems,
such
nanoparticles
hydrogels.
Due
the
unique
merits
anti‐tumor,
anti‐bacterial,
antioxidant,
anti‐inflammatory,
cardioprotective
properties
polyphenols,
systems
hold
great
promise
deal
wide
spectrum
diseases.
This
review
comprehensively
overviews
components,
intermolecular
interactions,
preparation
methods
implicated
assembly
systems.
In
addition,
their
medical
applications
are
introduced,
particularly
treatments
various
diseases,
tumors,
bacterial
infections,
inflammatory
bowel
disease
(IBD),
cardiovascular
diseases
(CVDs),
chronic
periodontitis,
acute
lung
injury,
osteoarthritis,
renal
fibrosis.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Авг. 5, 2024
The
limitations
associated
with
conventional
cancer
treatment
modalities,
particularly
for
breast
cancer,
underscore
the
imperative
developing
safer
and
more
productive
drug
delivery
systems.
A
promising
strategy
that
has
emerged
is
combination
of
chemotherapy
gas
therapy.
We
synthesized
curcumin-loaded
amorphous
calcium
carbonate
nanoparticles
(Cur-CaCO3)
via
a
diffusion
reaction
in
present
study.
Subsequently,
"one-step"
ethanol
injection
method
was
employed
to
fabricate
lipid-coated
(Cur-CaCO3@LA-Lip)
loaded
L-arginine,
aimed
at
harnessing
synergistic
effects
nitric
oxide
enhance
antitumor
efficacy.
Transmission
electron
microscopy
analysis
revealed
Cur-CaCO3@LA-Lip
were
subspherical
distinct
lipid
layer
encapsulating
periphery.
Fourier
transform
infrared
spectroscopy,
X-ray
powder
diffraction,
differential
scanning
calorimetry
results
confirmed
successful
synthesis
Cur-CaCO3@LA-Lip.
exhibited
significant
loading
capacities
8.89%
curcumin
3.1%
L-arginine.
In
vitro
vivo
assessments
demonstrated
facilitated
sustained
release
high
cellular
uptake,
substantial
tumor
accumulation,
excellent
biocompatibility.
Additionally,
showed
robust
cytotoxicity
potent
efficacy,
suggesting
their
potential
as
formidable
candidate
Abstract
Microwave
thermotherapy
(MWTT)
has
limited
its
application
in
the
clinic
due
to
high
rate
of
metastasis
and
recurrence
after
treatment.
Nitric
oxide
(NO)
is
a
gaseous
molecule
that
can
address
rates
MWTT
by
increasing
thermal
sensitivity,
down‐regulating
expression
hypoxia‐inducible
factor‐1
(HIF‐1),
inducing
immunogenic
cell
death
(ICD).
Therefore,
GaMOF‐Arg
designed,
gallium‐based
organic
skeleton
material
derivative
loaded
with
L‐arginine
(L‐Arg),
coupled
mitochondria‐targeting
drug
triphenylphosphine
(TPP)
on
surface
obtain
GaMOF‐Arg‐TPP
(GAT)
MW‐immunosensitizers.
When
GAT
MW‐immunosensitizers
are
introduced
into
mice
through
tail
vein,
reactive
oxygen
species
(ROS)
generated
L‐Arg
released
under
MW
action.
Then,
reacts
ROS
generate
NO,
which
not
only
downregulates
HIF‐1
improve
tumor
hypoxia
exacerbated
MW,
but
also
enhances
immune
responses
augment
calreticulin
(CRT)
exposure,
mobility
group
box
1
(HMGB1)
release,
T‐cell
proliferation
achieve
prevention
recurrence.
In
addition,
NO
induce
mitochondria
damage
increase
their
sensitivity
MWTT.
This
study
provides
unique
insight
use
metal‐organic
framework
enhance
therapy
offers
new
way
treat
cancer
efficiently.
