Hydroxyethyl starch-based self-reinforced nanomedicine inhibits both glutathione and thioredoxin antioxidant pathways to boost reactive oxygen species-powered immunotherapy

Biomaterials, Год журнала: 2024, Номер 311, С. 122673 - 122673

Опубликована: Июнь 17, 2024

Язык: Английский

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Direct and indirect approaches to red-shift photoactivated nitric oxide release

Coordination Chemistry Reviews, Год журнала: 2024, Номер 515, С. 215921 - 215921

Опубликована: Май 21, 2024

Nitric oxide (NO) is an important biochemical molecule that endogenously produced to act for instance as neurotransmitter, effect cell growth, or regulate the immune response. Therapeutic treatment with exogeneous NO difficult owing its gaseous and reactive nature and, not surprising, specific molecules deliver have been developed. Amongst various triggers deliberately release from these NO-releasing molecules, light most elegant allows a high degree of control over time location NO-release. For therapeutic applications, it necessary use long-wavelength light, preferably in red near infrared region, which challenging achieve. This review gives overview on approaches red-shift activation wavelength light-activated NO-release nitrosoamines, o-substituted nitroarenes, L-arginine, cupferron, nitrosyl metal complexes. While focusing single photon excitation events, direct mechanisms are covered well photoelectron transfer, energy chemiluminescence photothermal light-triggered oxidation pathways. each NO-releaser class, photochemical mechanism discussed, biological applications mentioned.

Язык: Английский

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Recent progress of porphyrin metal-organic frameworks for combined photodynamic therapy and hypoxia-activated chemotherapy

Chemical Communications, Год журнала: 2024, Номер 60(93), С. 13641 - 13652

Опубликована: Янв. 1, 2024

Hypoxia limits the phototherapeutic efficacy of porphyrin-based nMOFs; loading with hypoxia-activated drug TPZ enhances combined PDT and chemotherapy effects.

Язык: Английский

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Metastatic squamous cell carcinoma in the residual spleen diagnosed with emergency ultrasonography: A case report

Oncology Letters, Год журнала: 2025, Номер 29(4)

Опубликована: Фев. 5, 2025

Metastatic squamous cell carcinoma (SCC) in the spleen is a rare malignant tumor primarily originating from areas covered by epithelium. The present study reports case of 58‑year‑old man who had undergone radical gastrectomy for gastric SCC and subtotal splenectomy anemia previously, now presented with abdominal pain. On presentation to Emergency Department Shaoxing Second Hospital (Shaoxing, China), bedside emergency ultrasound (US) examination was performed, which revealed mass mimicking splenic abscess residual spleen. After ineffective anti‑inflammatory treatment, US‑guided biopsy perform2ed subsequent treatment confirmed diagnosis metastatic Point‑of‑care US first‑line imaging choice patients pain, as it can identify several pathological conditions. shows that point‑of‑care combined be used clarify diagnosis.

Язык: Английский

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Nutritional status in patients with COPD and its impact on biochemical status: A narrative review

Journal Of Advanced Pharmacy Education And Research, Год журнала: 2025, Номер 15(2), С. 31 - 39

Опубликована: Янв. 1, 2025

Язык: Английский

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Injectable long-acting formulations (ILAFs) and manufacturing techniques

Expert Opinion on Drug Delivery, Год журнала: 2024, Номер 21(6), С. 881 - 904

Опубликована: Июнь 2, 2024

Most therapeutics delivered using short-acting formulations need repeated administration, which can harm patient compliance and raise failure risks related to inconsistent treatment. Injectable long-acting (ILAFs) are controlled/sustained-release fabricated deliver active pharmaceutical ingredients (APIs) extend their half-life over days months. Longer half-lives of ILAFs minimize the necessity for frequent doses, increase compliance, reduce risk side effects from intravenous (IV) infusions. Using ILAF technologies, immediate drug release also be controlled, thereby minimizing potential adverse due high initial blood concentrations.

Язык: Английский

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Nanogenerator with L-Arginine loading: new choices as cascaded and synergistic nitric oxide/photodynamic antitumor agents

Materials Chemistry Frontiers, Год журнала: 2024, Номер 9(2), С. 204 - 222

Опубликована: Ноя. 27, 2024

In this review, the design idea, synergistic mechanism and application prospects of l -arginine-loaded nanogenerators with cascade NO/PDT for anti-tumor applications are summarized.

Язык: Английский

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