The Role and Mechanism of Paeoniae Radix Alba in Tumor Therapy

Molecules, Год журнала: 2024, Номер 29(7), С. 1424 - 1424

Опубликована: Март 22, 2024

Tumors have a huge impact on human life and are now the main cause of disease-related deaths. The means treatment surgery radiotherapy, but they more damaging to organism poor postoperative prognosis. Therefore, we urgently need safe effective drugs treat tumors. In recent years, Chinese herbal medicines been widely used in tumor therapy as complementary alternative therapies. Medicinal edible herbs popular become hot topic research, which not only excellent pharmacological effects activities, also almost no side effects. typical medicine food homology, some components Paeoniae Radix Alba (PRA, called Baishao China) shown good efficacy safety against cancer. Numerous studies that its active ingredients cancer through various pathways one important many antitumor compound formulas. this paper, reviewed literature intervention tumors mechanism action years found there is large amount effect total glucosides paeony (TGP) paeoniflorin (PF), well an in-depth discussion constituents, with view promote clinical development application field management.

Язык: Английский

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Precisely targeted drug delivery by mesenchymal stem cells-based biomimetic liposomes to cerebral ischemia-reperfusion injured hemisphere

Journal of Controlled Release, Год журнала: 2024, Номер 371, С. 484 - 497

Опубликована: Июнь 11, 2024

Язык: Английский

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Hybrid Biomembrane-Functionalized Nanorobots Penetrate the Vitreous Body of the Eye for the Treatment of Retinal Vein Occlusion

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Intravitreal injections of antivascular endothelial growth factor (VEGF) agents are the primary method for treating retinal vein occlusion (RVO). However, complex structure eye anatomy presents ocular barriers that impede drug delivery. Additionally, these drugs only manage complications associated with RVO and fail to address underlying cause vessel occlusions. Here, we describe a utilizes functionalized magnetically driven nanorobots overcome treat RVO. These developed using hybrid biomembrane combines stem cell membranes liposome-derived membranes, enveloping perfluorohexane, iron oxide nanoparticles, l-arginine. After intravitreal injection, can move directionally through penetrate vitreous body reach retina, by an external magnetic field. Subsequently, actively target inflammation sites at occluded vessels due presence membranes. In rat model RVO, enhanced targeting accumulation in ischemic were demonstrated following injections. Furthermore, application ultrasound triggers release l-arginine site occlusion, stimulating production nitric oxide, which promotes vasodilation restores blood flow, thereby achieving excellent therapeutic efficacy We believe methods hold significant promise overcoming challenges delivery effectively clinical applications.

Язык: Английский

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Anti-inflammatory effect of dental pulp stem cells

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 23, 2023

Dental pulp stem cells (DPSCs) have received a lot of attention as regenerative medicine tool with strong immunomodulatory capabilities. The excessive inflammatory response involves variety immune cells, cytokines, and has considerable impact on tissue regeneration. use DPSCs for controlling inflammation the purpose treating inflammation-related diseases autoimmune disorders such supraspinal nerve inflammation, pulmonary airways, systemic lupus erythematosus, diabetes mellitus is likely to be safer more than traditional medicines. mechanism anti-inflammatory effects relatively complex, it may that they themselves or some substances secrete regulate through immune-related signaling pathways. Most current studies are still at laboratory cellular level animal model level, believed efforts researchers, DPSCs/SHED expected transformed into excellent drugs clinical treatment related diseases.

Язык: Английский

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Mesenchymal Stem Cell Membrane‐Camouflaged Liposomes for Biomimetic Delivery of Cyclosporine A for Hepatic Ischemia‐Reperfusion Injury Prevention

Advanced Science, Год журнала: 2024, Номер 11(32)

Опубликована: Июнь 20, 2024

Abstract Hepatic ischemia‐reperfusion injury (HIRI) is a prevalent issue during liver resection and transplantation, with currently no cure or FDA‐approved therapy. A promising drug, Cyclosporin (CsA), ameliorates HIRI by maintaining mitochondrial homeostasis but has systemic side effects due to its low bioavailability high dosage requirements. This study introduces biomimetic CsA delivery system that directly targets hepatic lesions using mesenchymal stem cell (MSC) membrane‐camouflaged liposomes. These hybrid nanovesicles (NVs), leveraging MSC‐derived proteins, demonstrate efficient inflammatory chemotaxis, transendothelial migration, drug‐loading capacity. In mouse model, the NVs accumulated at sites entered hepatocytes, significantly reduced damage restore function only one‐tenth of dose typically required. Proteomic analysis verifies protection mechanism, which includes reactive oxygen species inhibition, preservation integrity, cellular apoptosis, suggesting potential for this strategy in intervention.

Язык: Английский

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Natural Polyphenol Delivered Methylprednisolone Achieve Targeted Enrichment for Acute Spinal Cord Injury Therapy

Small, Год журнала: 2024, Номер 20(46)

Опубликована: Авг. 6, 2024

Abstract The strong anti‐inflammatory effect of methylprednisolone (MP) is a necessary treatment for various severe cases including acute spinal cord injury (SCI). However, concerns have been raised regarding adverse effects from MP, which also severely limits its clinical application. Natural polyphenols, due to their rich phenolic hydroxyl chemical properties, can form dynamic structures without additional modification, achieving targeted enrichment and drug release at the disease lesion, making them highly promising carrier. Considering application challenges natural polyphenolic platform employed efficient delivery reducing systemic side effects. Both in vitro SCI models demonstrated polyphenols multiple advantages as carriers delivering MP: (1) Achieved maximum injured site 2 h post‐administration, met desires early diseases; (2) Traceless MP; (3) Reducing effects; (4) Endowed system with new antioxidative an aspect that needs be addressed diseases treatment. This study highlighted prospect robust based on successfully overcome barrier MP treatment, providing possibility widespread

Язык: Английский

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Lyophilizable Stem Cell‐Hybrid Liposome with Long‐Term Stability and High Targeting Capacity

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Май 23, 2024

Abstract The hybridization of liposome with stem cell membranes is an emerging technology to prepare the nanovehicle capacity disease‐responsive targeting. However, long‐term storage this hybrid has received limited attention in literature, which essential for its potential applicability clinic. Therefore, preservation activity cell‐hybrid using freeze‐drying investigated present study. Mesenchymal synthesized and feasibility under different conditions examined. Results reveal that pre‐freezing at −20 °C Tris buffer solution (pH 7.4) containing 10% trehalose can well preserve liposomal structure least three months. Notably, major membrane proteins on are protected formulation CXCR4‐associated targeting maintained both vitro vivo. Consequently, stored months demonstrates a comparable tumor inhibition as fresh‐prepared one. study provides first insights into lyophilization, may make important step forward enhancing stability these promising biomimetic ease logistics freeze‐storage clinical applications.

Язык: Английский

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Route of Application and Dose Evaluation of Dental Pulp Stem Cells for the Treatment of Sialadenitis Caused by Sjögren’s Syndrome: A Preclinical Study

Biomedicines, Год журнала: 2025, Номер 13(5), С. 1068 - 1068

Опубликована: Апрель 28, 2025

Background: Sjögren's syndrome (SS) is an autoimmune disorder characterized by sicca and/or systemic manifestations. In this study, non-obese diabetic (NOD) mice were used as animal model for studying SS, to evaluate the optimal administration route and dose range of dental pulp stem cells (DPSCs) in treatment sialadenitis caused SS. Methods: Different doses DPSCs transplanted into submandibular glands (SMGs) 14-week-old NOD through two different methods: injection or retrograde perfusion catheter orifice SMG. At 21 weeks age, saliva flow rate (SFR), ectopic lymphocytes, CD4+ T-cell infiltration measured. Tumor necrosis factor-alpha (TNF-α) interferon-gamma (IFN-γ) glandular tissues also quantitatively detected. Results: Compared with untreated PBS-injected controls, different-dose groups methods showed increased varying degrees, reduced lymphocytes T SMG, decreased IFN-γ/TNF-α levels. Finally, we compared these routes found that 2 × 105 presents good therapeutic effects. Conclusions: DPSC a simple effective method, which worthy further investigation clinical trials.

Язык: Английский

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Precision Nanomedicine for Pneumonocyte-Targeting: Emerging Strategies and Clinical Prospects in Refractory Pulmonary Disease Therapy

Biomaterials, Год журнала: 2025, Номер 323, С. 123420 - 123420

Опубликована: Май 20, 2025

Язык: Английский

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Lipid–Polymer Hybrid Nanoparticles in Microparticle-Based Powder: Evaluating the Potential of Methylprednisolone Delivery for Future Lung Disease Treatment via Inhalation

Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1454 - 1454

Опубликована: Ноя. 14, 2024

Background. Lipid–polymer hybrid nanoparticles (LPHNPs) offer a promising method for delivering methylprednisolone (MePD) to treat lung inflammation, addressing aggregation issues seen with polymer-only formulations. Objectives. This study aimed develop LPHNPs MePD delivery, assessing their physicochemical properties, drug loading, cytocompatibility, and release profiles, ultimately enabling inhalable microparticle-based powder. Methods. The were formulated using α,β-poly(N-2-hydroxyethyl)-DL-aspartamide-g-Rhodamine B-g-poly(lactic acid) (PHEA-g-RhB-g-PLA) phospholipids DPPC, DOTAP, DSPE-PEG2000 in 45:30:25 weight ratio. Their size, redispersion after freeze-drying, loading (DL%), controlled evaluated. Cytocompatibility was assessed on 16-HBE cell lines, measuring anti-inflammatory effects via IL-6 IL-8 levels. Spray drying optimized produce microparticles mannitol (MAN), leucine (LEU), N-acetylcysteine (NAC). Results. had size of 186 nm DL% 2.9% MePD. They showed good significantly reducing yielded fine particle fraction (FPF) 62.3% mass median aerodynamic diameter (MMAD) 3.9 µm. Inclusion LPHNPs@MePD (0.25% w/v) resulted FPF MMAD values 56.7% 4.4 In conclusion, this described the production novel powders as carriers MePD-loaded nanostructures favorable aerosol performance, indicating potential an effective therapy inflammation corticosteroids, especially treating chronic diseases.

Язык: Английский

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