Metal Nanoparticles: Advanced and Promising Technology in Diabetic Wound Therapy

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 965 - 992

Опубликована: Янв. 1, 2024

Abstract: Diabetic wounds pose a significant challenge to public health, primarily due insufficient blood vessel supply, bacterial infection, excessive oxidative stress, and impaired antioxidant defenses. The aforementioned condition not only places physical burden on patients' prognosis, but also amplifies the economic strain medical system in treating diabetic wounds. Currently, effectiveness of available treatments for is limited. However, there hope potential metal nanoparticles (MNPs) address these issues. MNPs exhibit excellent anti-inflammatory, antioxidant, antibacterial pro-angiogenic properties, making them promising solution In addition, stimulate expression proteins that promote wound healing serve as drug delivery systems small-molecule drugs. By combining with other biomaterials such hydrogels chitosan, novel dressings can be developed revolutionize treatment present article provides comprehensive overview research progress utilization Building upon this foundation, we summarize underlying mechanisms involved discuss application delivery. Furthermore, provide an extensive analysis discussion clinical implementation dressings, while highlighting future prospects utilizing management. conclusion, represent strategy healing. Future directions include biological nanomaterials synthesize new or physicochemical properties Synthetic contain play role all stages healing, stable physiological environment wound-healing process. Keywords: nanoparticles, wound, delivery, activity

Язык: Английский

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All‐in‐One Self‐Powered Microneedle Device for Accelerating Infected Diabetic Wound Repair

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(13)

Опубликована: Фев. 7, 2024

Abstract Diabetic wound healing remains a significant clinical challenge due to the complex microenvironment and attenuated endogenous electric field. Herein, novel all‐in‐one self‐powered microneedle device (termed TZ@mMN‐TENG) is developed by combining multifunctional carried tannin@ZnO microparticles (TZ@mMN) with triboelectric nanogenerator (TENG). In addition delivery of tannin Zn 2+ , TZ@mMN also effectively conducts electrical stimulation (ES) infected diabetic wounds. As device, TENG can convert biomechanical motion into exogenous ES accelerate healing. vitro experiment demonstrated that shows excellent conductive, high antioxidant ability, effective antibacterial properties against both Staphylococcus aureus Escherichia coli (>99% rates). Besides, TZ@mMN‐TENG promote cell proliferation migration. rat full‐thickness skin model eliminate bacteria, epidermal growth (regenerative epidermis: ≈303.3 ± 19.1 µm), enhance collagen deposition, inhibit inflammation (lower TNF‐α IL‐6 expression), angiogenesis (higher CD31 VEGF expression) repair. Overall, provides promising strategy for application in

Язык: Английский

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Nanozyme‐Incorporated Microneedles for the Treatment of Chronic Wounds

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(20)

Опубликована: Май 25, 2024

Acute wounds are converted to chronic due advanced age and diabetic complications. Nanozymes catalyze ROS production kill bacteria without causing drug resistance, while microneedles (MNs) can break through the skin barrier deliver drugs effectively. be intergrateded into MNs delivery systems improve painless delivery. It also reduce effective dose of sterilization increasing efficiency effectively killing wounded preventing resistance. This paper describes various types metal nanozymes from previous studies compares their mutual enhancement with nanozymes. The pooled results show that MNs, material innovation, able both penetrate scab exert additional anti-inflammatory bactericidal effects. catalytic effect some accelerate lysis or create a cascade reaction against inflammation infection. However, issue increased toxicity associated penetration clinical translation remains challenge. study reviews latest published corresponding challenges use combined for treatment wounds, providing further information future research.

Язык: Английский

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Recent advances of hydrogels as smart dressings for diabetic wounds

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(5), С. 1126 - 1148

Опубликована: Янв. 1, 2024

This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.

Язык: Английский

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Implantable Microneedles Loaded with Nanoparticles Surface Engineered Escherichia coli for Efficient Eradication of Triple-Negative Breast Cancer Stem Cells

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Eliminating cancer stem cells (CSCs) is essential for the effective treatment of triple-negative breast (TNBC). This study synthesized Au@cerium-zinc composite core@shell nanoparticles (Au@Zn/CeO) that were subsequently conjugated with Escherichia coli (E. coli) to create engineered bacterium AZCE, which was then combined microneedle carriers and freeze-dried obtain AZCE-MN. Upon implantation into TNBC tumors, inherent properties E. facilitate AZCE penetrate extracellular matrix break through basement membrane, enabling delivery AZC CSCs-enriched regions deep within tumor. The released Zn2+ induces mitochondrial dysfunction amplifies reactive oxygen species (ROS) production. redox cycling between Ce3+/Ce4+ effectively depleted glutathione, further increased ROS generation. Under near-infrared laser irradiation, Au nanorods initiated photothermal therapy, ablating CSCs while amplifying catalytic reactions ionic effects. microneedle-mediated bacteria improved nanodrug penetration in tumor tissues, providing new insights clinical treatment.

Язык: Английский

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Potential Applications of Rare Earth Metal Nanoparticles in Biomedicine

Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 154 - 154

Опубликована: Янв. 24, 2025

In recent years, the world scientific community has shown increasing interest in rare earth metals general and their nanoparticles particular. Medicine pharmaceuticals are no exception this matter. review, we have considered main opportunities potential applications of metal (gadolinium, europium, ytterbium, holmium, lutetium, dysprosium, erbium, terbium, thulium, scandium, yttrium, lanthanum, neodymium, promethium, samarium, praseodymium, cerium) biomedicine, with data ranging from single reports effects found vitro to numerous independent vivo studies, as well a number challenges for wider application. The areas application metals, including future, diagnosis treatment malignant neoplasms, therapy infections, use antioxidant regenerative properties nanoparticles. These determined both by themselves need search new approaches solve urgent biomedical public health problems. Oxide forms lanthanides most often used biomedicine due greatest biocompatibility nanoscale size, providing penetration through biological membranes. However, existing contradictory or insufficient on acute chronic toxicity still make widespread difficult. There various modification methods (addition excipients, creation nanocomposites, changing morphology particles) that can reduce these effects. At same time, despite some representatives clinical practice, further studies establish full range pharmacological toxic effects, modify remain relevant.

Язык: Английский

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“Monitor-and-treat” that integrates bacterio-therapeutics and bio-optics for infected wound management

Bioactive Materials, Год журнала: 2025, Номер 48, С. 118 - 134

Опубликована: Фев. 15, 2025

Язык: Английский

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Gold nanoclusters encapsulated microneedle patches with antibacterial and self‐monitoring capacities for wound management

Aggregate, Год журнала: 2024, Номер 5(3)

Опубликована: Янв. 25, 2024

Abstract The management of infected wounds is always great significance and urgency in clinical biomedical fields. Recent efforts this area are focusing on the development functional wound patches with effective antibacterial, drug delivery, sensor properties. Here, we present novel hyaluronic acid (HA) microneedle these features by encapsulating aminobenzeneboronic acid‐modified gold nanoclusters (A‐GNCs) for management. A‐GNCs loaded were derived from negative‐mold replication showed high mechanical strength to penetrate skin. release was realized degradation HA, self‐monitor released actives based dynamic bright orange fluorescence emitted under ultraviolet radiation. As could destroy bacteria membranes, excellent vitro antibiosis ability. Based features, have demonstrated inhibition, residual self‐monitoring, healing promotion abilities Escherichia coli‐ or Staphylococcus aureus ‐infected These results indicated potential such applications.

Язык: Английский

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Biomaterials with cancer cell-specific cytotoxicity: challenges and perspectives

Chemical Society Reviews, Год журнала: 2024, Номер 53(17), С. 8847 - 8877

Опубликована: Янв. 1, 2024

Significant advances have been made in materials for biomedical applications, including tissue engineering, bioimaging, cancer treatment,

Язык: Английский

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Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Авг. 13, 2024

Abstract The eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as blood-retinal barrier and corneal impermeability. Conventional administration methods often fail sustain therapeutic levels may compromise patient safety compliance. Polysaccharide-based microneedles (PSMNs) have emerged transformative solution for ophthalmic delivery. However, comprehensive review of PSMNs in ophthalmology has not been published date. In this review, we critically examine synergy between polysaccharide chemistry microneedle technology enhancing ocular We provide thorough analysis PSMNs, summarizing design principles, fabrication processes, addressed during fabrication, including improving comfort also describe recent advances performance various both research clinical scenarios. Finally, current regulatory frameworks market barriers that are relevant commercial advancement final perspective on area.

Язык: Английский

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