Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 19, 2025
Comprehensive
Summary
The
development
of
photodynamic
therapy
(PDT),
from
its
initial
discovery
effects
to
current
use
in
various
medical
conditions,
is
a
testament
therapeutic
potential.
Recent
breakthroughs
nanotechnology
have
significantly
enhanced
the
effectiveness
PDT.
Typical
nanomaterials
(NMs),
including
metal‐organic
frameworks
(MOFs),
covalent
organic
(COFs),
and
nanozymes
been
introduced
enhance
efficacy
because
they
can
delivery
PSs,
effectively
overcome
insufficient
targeting
specificity,
limited
tissue
penetration
depth,
hypoxic
microenvironments,
thereby
amplifying
efficacy.
However,
clinical
application
these
NMs
PDT
faces
several
challenges,
concerns
regarding
biocompatibility,
long‐term
biosafety,
economic
feasibility.
To
further
advance
PDT,
researchers
should
focus
on
designing
improve
outcomes,
exploring
combination
therapies
with
conducting
translational
trials
validate
safety
novel
approaches.
This
review
summarizes
recent
progress
based
NMs,
especially
MOFs,
COFs
their
disease
treatment.
We
aim
provide
guidance
for
future
research
practice
advancing
NMs‐enhanced
paving
way
more
effective
strategies.
Key
Scientists
ACS Nano,
Год журнала:
2024,
Номер
18(19), С. 12049 - 12095
Опубликована: Май 2, 2024
Cancer,
as
one
of
the
leading
causes
death
worldwide,
drives
advancement
cutting-edge
technologies
for
cancer
treatment.
Transition-metal-based
nanozymes
emerge
promising
therapeutic
nanodrugs
that
provide
a
reference
therapy.
In
this
review,
we
present
recent
breakthrough
First,
comprehensively
outline
preparation
strategies
involved
in
creating
transition-metal-based
nanozymes,
including
hydrothermal
method,
solvothermal
chemical
reduction
biomimetic
mineralization
and
sol–gel
method.
Subsequently,
elucidate
catalytic
mechanisms
(catalase
(CAT)-like
activities),
peroxidase
(POD)-like
oxidase
(OXD)-like
activities)
superoxide
dismutase
(SOD)-like
along
with
their
activity
regulation
such
morphology
control,
size
manipulation,
modulation,
composition
adjustment
surface
modification
under
environmental
stimulation.
Furthermore,
elaborate
on
diverse
applications
anticancer
therapies
encompassing
radiotherapy
(RT),
chemodynamic
therapy
(CDT),
photodynamic
(PDT),
photothermal
(PTT),
sonodynamic
(SDT),
immunotherapy,
synergistic
Finally,
challenges
faced
by
are
discussed
alongside
future
research
directions.
The
purpose
review
is
to
offer
scientific
guidance
will
enhance
clinical
based
transition
metals.
Abstract
In
recent
years,
there
has
been
growing
interest
in
developing
innovative
materials
and
therapeutic
strategies
to
enhance
wound
healing
outcomes,
especially
for
chronic
wounds
antimicrobial
resistance.
Metal–organic
frameworks
(MOFs)
represent
a
promising
class
of
next‐generation
dressings.
Their
high
surface
area,
pore
structures,
stimuli‐responsiveness,
antibacterial
properties,
biocompatibility,
potential
combination
therapies
make
them
suitable
complex
care
challenges.
MOF‐based
composites
promote
cell
proliferation,
angiogenesis,
matrix
synthesis,
acting
as
carriers
bioactive
molecules
promoting
tissue
regeneration.
They
also
have
stimuli‐responsivity,
enabling
photothermal
skin
cancer
infections.
Herein,
critical
analysis
the
current
state
research
on
MOFs
dressings
is
provided,
offering
valuable
insights
into
applications,
challenges,
future
directions
this
field.
This
literature
review
targeted
multifunctionality
nature
wound‐disease
therapy
from
different
aspects
discussed
most
advancements
made
context,
reader
will
find
how
contributed
field
yield
more
effective,
functional,
they
lead
next
generation
biomaterials
ACS Nano,
Год журнала:
2024,
Номер
18(20), С. 12639 - 12671
Опубликована: Май 8, 2024
Since
the
discovery
of
ferromagnetic
nanoparticles
Fe3O4
that
exhibit
enzyme-like
activity
in
2007,
research
on
nanoenzymes
has
made
significant
progress.
With
in-depth
study
various
and
rapid
development
related
nanotechnology,
have
emerged
as
a
promising
alternative
to
natural
enzymes.
Within
nanozymes,
there
is
category
metal-based
single-atom
nanozymes
been
rapidly
developed
due
low
cast,
convenient
preparation,
long
storage,
less
immunogenicity,
especially
higher
efficiency.
More
importantly,
possess
capacity
scavenge
reactive
oxygen
species
through
mechanisms,
which
beneficial
tissue
repair
process.
Herein,
this
paper
systemically
highlights
types
metal
their
catalytic
recent
applications
repair.
The
existing
challenges
are
identified
prospects
future
composed
metallic
nanomaterials
proposed.
We
hope
review
will
illuminate
potential
repair,
encouraging
sequential
clinical
translation.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 20, 2025
The
advent
of
nanozymes
has
revolutionized
approaches
to
cancer
diagnosis
and
therapy,
introducing
innovative
strategies
that
address
the
limitations
conventional
treatments.
Nanozyme
nanostructures
with
enzyme-mimicking
catalytic
abilities
exhibit
exceptional
stability,
biocompatibility,
customizable
functions,
positioning
them
as
promising
tools
for
theranostics.
By
emulating
natural
enzyme
reactions,
can
selectively
target
eradicate
cells,
minimizing
harm
adjacent
healthy
tissues.
Nanozymes
also
be
functionalized
specific
targeting
ligands,
allowing
precise
delivery
regulated
release
therapeutic
agents,
improving
treatment
effectiveness
reducing
adverse
effects.
However,
issues
such
selectivity,
regulatory
compliance
remain
critical
challenges
clinical
application
nanozymes.
This
review
provides
an
overview
nanozymes,
highlighting
their
unique
properties,
various
classifications,
activities,
diverse
applications
in
strategic
oncological
deployment
could
profoundly
impact
future
advancements
personalized
medicine,
recent
progress
prospective
directions
enzyme-mimetic
treatment.
summarizes
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(17)
Опубликована: Янв. 3, 2024
Abstract
Hypoxia,
as
a
distinctive
feature
of
tumors,
is
closely
related
to
tumor
recurrence,
metastasis,
and
treatment
resistance.
Metal–organic
framework
(MOF)
exhibits
an
increasing
number
advantages
in
cancer
therapy
owing
its
porous
structure,
large
specific
surface
area,
tunable
function.
The
MOF
nanocomposites
constructed
by
adjusting
components
can
effectively
overcome
hypoxia
significantly
enhance
the
anti‐tumor
effect.
In
this
review,
hypoxic
characteristics
tumors
current
strategies
for
constructing
that
are
summarized,
including
delivering
O
2
or
endogenously
generating
elevate
intra‐tumor
content;
inhibiting
HIF‐1
induced
products
alleviate
hypoxia;
reducing
cellular
aerobic
respiration
decrease
consumption,
exacerbating
improve
efficacy
hypoxia‐activated
pre‐drugs.
At
same
time,
applications
applied
different
therapeutic
methods
at
present
stage
described,
finally,
challenges
opportunities
further
development
discussed.
Journal of Nanotheranostics,
Год журнала:
2025,
Номер
6(1), С. 4 - 4
Опубликована: Янв. 31, 2025
Regrettably,
despite
undeniable
advances
in
cancer
diagnosis
and
therapy,
primary
brain
(or
cancer)
remains
one
of
the
deadliest
forms
malignant
tumors,
where
glioblastoma
(GBM)
is
known
as
most
diffuse
glioma
astrocytic
lineage.
Fortunately,
to
improve
this
scenario,
remarkable
progress
nanotechnology
has
brought
new
promise
raised
expectations
treatment.
Nanomedicine,
principally
an
area
amalgamating
with
biology
medicine,
demonstrated
a
pivotal
role,
starting
earliest
detection
while
also
offering
novel
multimodal
therapy
alternatives.
In
vast
realm
nanotechnology,
nanozymes,
type
nanomaterial
intrinsic
enzyme-like
activities
characteristics
connecting
fields
nanocatalysts,
enzymology,
biology,
have
emerged
powerful
nanotools
for
theranostics.
Hence,
fascinating
field
research
experienced
exponential
growth
recent
years.
As
it
virtually
impossible
cover
all
literature
on
broad
domain
science
paper,
review
focuses
presenting
multidisciplinary
approach,
its
content
extending
from
fundamental
knowledge
nanozymes
enzyme-mimicking
catalysis
targeting
cancers.
Although
we
are
at
very
early
stages
research,
can
be
envisioned
that
strategic
development
theranostics
will
positively
offer
disruptive
nanoplatforms
future
nano-oncology.
Nanozymes,
nanomaterials
exhibiting
enzyme‐mimicking
activities,
have
gained
considerable
interest
in
biomedicine
due
to
their
stability,
adjustability,
and
cost‐efficiency.
Among
these,
metal–organic
framework
(MOF)‐based
nanozymes
distinguish
themselves
by
distinct
structure
customizable
characteristics.
Researchers
explored
MOF‐based
as
a
platform
for
developing
stimuli‐responsive
behaviors.
This
work
first
presents
the
categorization
of
nanozymes,
which
are
designed
mimic
catalytic
functions
oxidases,
peroxidases,
catalase,
superoxide
dismutase,
hydrolases,
multifunctional
enzymes.
Crafting
includes
customizing
reactions
particular
stimuli,
including
pH,
temperature,
light,
or
biomolecular
triggers,
ensuring
enhanced
specificity
potency
performance
amid
environmental
changes.
Moreover,
these
exhibit
immense
potential
biomedical
applications,
playing
crucial
roles
therapeutic
interventions
like
cancer
therapy
tissue
regeneration.
Finally,
article
delves
into
future
opportunities
challenges
within
emerging
research
frontiers.
These
offer
novel
avenues
advanced
strategies,
providing
prospects
innovative
applications.
