Ultrasound-responsive Bi2MoO6-MXene heterojunction as ferroptosis inducers for stimulating immunogenic cell death against ovarian cancer

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 11, 2024

Abstract Background Ovarian cancer (OC) has the highest fatality rate among all gynecological malignancies, necessitating exploration of novel, efficient, and low-toxicity therapeutic strategies. Ferroptosis is a type programmed cell death induced by iron-dependent lipid peroxidation can potentially activate antitumor immunity. Developing highly effective ferroptosis inducers may improve OC prognosis. Results In this study, we developed an ultrasonically controllable two-dimensional (2D) piezoelectric nanoagonist (Bi 2 MoO 6 -MXene) to induce ferroptosis. A Schottky heterojunction between Bi (BMO) MXene reduced bandgap width 0.44 eV, increased carrier-separation efficiency, decreased recombination electron–hole pairs under ultrasound stimulation. Therefore, reactive oxygen species yield was enhanced. Under spatiotemporal excitation, BMO-MXene effectively inhibited proliferation more than 90%, peroxidation, mitochondrial-membrane potential, inactivated glutathione peroxidase cystathionine transporter protein system, thereby causing in tumor cells. cells further activated immunogenic death, facilitating dendritic maturation stimulating Conclusion We have succeeded developing potent inducer (BMO-MXene), capable inhibiting progression through sonodynamic-ferroptosis-immunogenic pathway. Graphical

Язык: Английский

---

Photoimmunotherapy for cancer treatment based on organic small molecules: Recent strategies and future directions

Translational Oncology, Год журнала: 2024, Номер 49, С. 102086 - 102086

Опубликована: Авг. 24, 2024

Photodynamic therapy (PDT) is considered as a promising anticancer approach, owning to its high efficiency and spatiotemporal selectivity. Ample evidence indicated that PDT can trigger immunogenic cell death by releasing antigens activate immune cells promote anti-tumor immunity. Nevertheless, the inherent nature of tumors their complex heterogeneity often limits PDT, which be overcome with novel strategy photo-immunotherapy (PIT) strategy. By exploring principles induction ICD enhancement, combined other therapies such chemotherapy or checkpoint blockade, tailored solutions designed address specific challenges drug resistance, hypoxic conditions, tumor immunosuppressive microenvironments (TIMEs), enables targeted enhancement systemic immunity most distant recurrent cancers. The present article summarizes strategies PIT discusses recent existing limitations. More importantly, we anticipate perspectives presented herein will help clinical translation associated PIT.

Язык: Английский

---

Charge-Reversal Nano-Drug Delivery Systems in the Tumor Microenvironment: Mechanisms, Challenges, and Therapeutic Applications

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 9779 - 9779

Опубликована: Сен. 10, 2024

The charge-reversal nano-drug delivery system (CRNDDS) is a promising for delivering chemotherapy drugs and has gained widespread application in cancer treatment. In this review, we summarize the recent advancements CRNDDSs terms of We also delve into mechanism CRNDDSs, focusing on acid-responsive, redox-responsive, enzyme-responsive mechanisms. This study elucidates how these systems undergo charge transitions response to specific microenvironmental stimuli commonly found tumor tissues. Furthermore, review explores pivotal role diagnosis treatment, their potential limitations. By leveraging unique physiological characteristics tumors, such as acidic pH, redox potential, enzyme activity, demonstrate enhanced accumulation penetration at sites, resulting improved therapeutic efficacy diagnostic accuracy. implications highlight drug novel targeted strategy therapy diagnosis.

Язык: Английский

---

Induced Ferroptosis Pathway by Regulating Cellular Lipid Peroxidation With Peroxynitrite Generator for Reversing “Cold” Tumors

Small, Год журнала: 2024, Номер unknown

Опубликована: Сен. 16, 2024

Abstract Overcoming the resistance of tumor cells to apoptosis and immunosuppression is an important challenge improve immunotherapy. Non‐apoptotic death mode ferroptosis has been regarded as a new strategy enhance immunotherapy against drug‐resistant cancers. The lethal accumulation lipid peroxides (LPO) determines progress ferroptosis. high susceptibleness provides opportunity for combating triple‐negative breast cancer. Reactive nitrogen species (RNS) produced by nitric oxide (NO) reactive oxygen (ROS) more than ROS cells. Herein, RNS‐mediated inducing pathway proposed improving LPO accumulation, constructed multifunctional liposome (Lipo‐MT‐SNAP) comprised peroxynitrite (ONOO − ) generator, targeted group, inhibiting glutathione peroxidase 4 (GPX4), basic units (dipalmitoyl phosphatidylcholine cholesterol). significant enhancement resulted from intense oxidative damage ONOO impaired synthesis GPX4 depleting glutathione, which further amplified triggered immunogenic cell death. In vivo, photoimmunotherapy can promote polarization M2 M1 macrophages dendritic maturation, infiltrate T cells, regulate secretion inflammatory factors, reprogram microenvironment. powerful induces strong immunogenicity effectively inhibit proliferation.

Язык: Английский

---

Novel Tris-bipyridine Based Ru(II) Complexes as Type-I/-II Photosensitizers for Antitumor Photodynamic Therapy Through Ferroptosis and Immunogenic Cell Death

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 279, С. 116909 - 116909

Опубликована: Сен. 24, 2024

Язык: Английский

---