Catalyzing Generation and Stabilization of Oxygen Vacancies on CeO_2−x Nanorods by Pt Nanoclusters as Nanozymes for Catalytic Therapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(31)

Опубликована: Сен. 14, 2023

Abstract Although CeO 2 nanomaterials have been widely explored as nanozymes for catalytic therapy, they still suffer from relatively low activities. Herein, the catalyzing generation and stabilization of oxygen vacancies on nanorods by Pt nanoclusters via H gas reduction under mild temperature (350 °C) to obtain Pt/CeO 2− x , which can serve a highly efficient nanozyme cancer is reported. The deposited atomic layer deposition technique not only catalyst generate through hydrogen spillover effect, but also stabilize generated vacancies. Meanwhile, provide anchoring sites forming strong metal‐support interactions thus preventing their agglomerations. Importantly, reduced at 350 °C (Pt/CeO ‐350R) exhibits excellent enzyme‐mimicking activity reactive species (e.g., ·OH) compared other control samples, including temperatures, achieving performance tumor‐specific therapy efficiently eliminate cells in vitro ablate tumors vivo. ‐350R originates good activities vacancy‐rich nanoclusters.

Язык: Английский

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Electrochemical immunosensor utilizing Zn-Fe-N-C single-atom nanozyme and Ti3C2Tx@Au for ultrasensitive detection of cytokeratins21-1

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112810 - 112810

Опубликована: Янв. 1, 2025

Язык: Английский

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Hypoxia-Targeted-Therapy: Mussel-Inspired hollow polydopamine nanocarrier containing MoS2 nanozyme and Tirapazamine with Anti-Angiogenesis Property for synergistic tumor therapy

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 685, С. 396 - 414

Опубликована: Янв. 20, 2025

Язык: Английский

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NIR triggered polydopamine coated cerium dioxide nanozyme for ameliorating acute lung injury via enhanced ROS scavenging

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июнь 8, 2024

Abstract Acute lung injury (ALI) is a life threatening disease in critically ill patients, and characterized by excessive reactive oxygen species (ROS) inflammatory factors levels the lung. Multiple evidences suggest that nanozyme with diversified catalytic capabilities plays vital role this fatal injury. At present, we developed novel class of polydopamine (PDA) coated cerium dioxide (CeO 2 ) (Ce@P) acts as potent ROS scavenger for scavenging intracellular suppressing responses against ALI. Herein, aimed to identify Ce@P combining NIR irradiation could further strengthen its capacity. Specifically, triggered exhibited most antioxidant anti-inflammatory behaviors lipopolysaccharide (LPS) induced macrophages through decreasing levels, down-regulating TNF-α, IL-1β IL-6, up-regulating level cytokine (SOD-2), inducing M2 directional polarization (CD206 up-regulation), increasing expression HSP70. Besides, performed intravenous (IV) injection LPS ALI rat model, found it significantly accumulated tissue 6 h after injection. It was also observed + presented superior inflammation, alleviating diffuse alveolar damage, well promoting repair. All all, has strategy using synergistic enhanced treatment ALI, which can serve promising therapeutic clinical derived diseases well.

Язык: Английский

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Aluminum-Decorated MIL-100(Fe) Nanozyme for the Detection of Glutathione

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(5), С. 4764 - 4771

Опубликована: Фев. 21, 2024

Nanozymes are nanomaterials with natural enzyme characteristics, which expected to be potential substitutes of traditional enzymes. In this study, the 1Al/MIL-100(Fe) nanozymes excellent peroxidase-like activity were synthesized by ultrathin modification (one-cycle Al2O3) strategy atomic layer deposition, whose is almost doubled compared MIL-100(Fe) nanozymes. Investigation catalytic mechanism indicates that increased amount hydroxyl radical responsible for much-enhanced Furthermore, effect designed inhibited glutathione through consuming oxidized 3,3′,5,5′-tetramethylbenzidine in reaction system. The also achieve sensitive and selective detection glutathione, have an linear response concentration range 0.01–1000 μM a limit 2.2 nM. can potentially extended synthesize other high-efficiency nanozyme materials.

Язык: Английский

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Nanomaterials for Targeted Therapy of Kidney Diseases: Strategies and Advances

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101534 - 101534

Опубликована: Янв. 29, 2025

The treatment and management of kidney diseases pose a significant global burden. Due to the presence blood circulation barriers glomerular filtration barriers, drug therapy for faces challenges such as poor renal targeting, short half-life, severe systemic side effects, severely hindering therapeutic progress. Therefore, research development kidney-targeted agents is great clinical significance. In recent years, application nanotechnology in field nephrology has shown potential revolutionizing diagnosis diseases. Carefully designed nanomaterials can exhibit optimal biological characteristics, influencing various aspects circulation, retention, excretion. Rationally designing modifying based on anatomical structure pathophysiological environment achieve highly specific or nanodrug delivery systems both feasible promising. Based targeted diseases, this review discusses advantages limitations current nanomedicine summarizes active/passive targeting strategies, order further promote through preliminary summary previous studies future prospects.

Язык: Английский

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Nanozyme based on bimetallic metal–organic frameworks and their applications: A review

Microchemical Journal, Год журнала: 2024, Номер unknown, С. 112363 - 112363

Опубликована: Дек. 1, 2024

Язык: Английский

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Cu-based materials as co-catalysts for photocatalytic CO2 reduction: A mini review

Materials Today Sustainability, Год журнала: 2024, Номер 26, С. 100796 - 100796

Опубликована: Май 6, 2024

Язык: Английский

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Photothermally Active Quantum Dots in Cancer Imaging and Therapeutics: Nanotheranostics Perspective

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Cancer is becoming a global threat, as the cancerous cells manipulate themselves frequently, resulting in mutants and more abnormalities. Early-stage real-time detection of cancer biomarkers can provide insight into designing cost-effective diagnostic therapeutic modalities. Nanoparticle quantum dot (QD)-based approaches have been recognized clinically relevant methods to detect disease at molecular level. Over decades, an emergent noninvasive approach, photothermal therapy has evolved eradicate cancer. Moreover, various structures, viz., nanoparticles, clusters, dots, etc., tested bioimaging agents identify tumor selectively. Among them, QDs versatile probes. They attracted enormous attention for imaging applications due their unique colloidal stability, optical physicochemical properties, biocompatibility, easy surface conjugation, scalable production, etc. However, few critical concerns QDs, precise engineering sensing, selective interaction with biological system, associated toxicity, restrict potential intervention curing are yet be explored. According U.S. Food Drug Administration (FDA), there no specific regulation approval nanomedicines. Therefore, these nanomedicines undergo traditional drug, biological, device process. market survey increasing, prospects translational nanomedicine very promising. From this perspective, we discuss importance imaging, usage pertinent cancer, especially its early stages. also rapidly growing view QDs. The long-term safety studies cellular could enhance visibility bring photothermally active clinical stage concurrently FDA approval.

Язык: Английский

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Modification strategies of TiO2-based nanocatalysts for CO2 reduction through photocatalysis: A mini review

Applied Catalysis A General, Год журнала: 2024, Номер unknown, С. 120054 - 120054

Опубликована: Дек. 1, 2024

Язык: Английский

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