Materials Today Bio, Год журнала: 2024, Номер 30, С. 101435 - 101435
Опубликована: Дек. 28, 2024
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(30)
Опубликована: Июль 22, 2024
Abstract Due to repeated microbial infection, persistent inflammation, excessive oxidative stress, and cell dysfunction, chronic wounds are difficult heal, posing a serious threat public health. Therefore, developing multifunctional wound dressings that can regulate the complex microenvironment of enhance cellular function holds great significance. Recently, chitosan has emerged as promising biopolymer for healing due its excellent biocompatibility, biodegradability, versatile bioactivity. The aim this review is provide comprehensive understanding mechanisms delayed discuss healing–promoting properties derivatives, such good antibacterial activity, hemostatic capacity, ability promote tissue regeneration. On basis, potential applications chitosan‐based hydrogels summarized in healing, including providing suitable microenvironment, eliminating bacterial infections, promoting hemostasis, inhibiting alleviating In addition, concerns perspectives clinical application also discussed.
Язык: Английский
Процитировано
23
Gels, Год журнала: 2024, Номер 10(3), С. 175 - 175
Опубликована: Фев. 29, 2024
The management of wound healing represents a significant clinical challenge due to the complicated processes involved. Chitosan has remarkable properties that effectively prevent certain microorganisms from entering body and positively influence both red blood cell aggregation platelet adhesion in bloodstream, resulting favorable hemostatic outcome. In recent years, chitosan-based hydrogels have been widely used as dressings their biodegradability, biocompatibility, safety, non-toxicity, bioadhesiveness, soft texture resembling extracellular matrix. This article first summarizes an overview main chemical modifications chitosan for then reviews desired hydrogel dressings. applications healing, including burn wounds, surgical infected diabetic wounds are discussed. Finally, future prospects It is anticipated this review will form basis development range treatment.
Язык: Английский
Процитировано
18
Separation and Purification Technology, Год журнала: 2024, Номер unknown, С. 129751 - 129751
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
18
Acta Biomaterialia, Год журнала: 2024, Номер 184, С. 156 - 170
Опубликована: Июнь 17, 2024
Язык: Английский
Процитировано
7
Reactive and Functional Polymers, Год журнала: 2024, Номер 197, С. 105866 - 105866
Опубликована: Фев. 26, 2024
Язык: Английский
Процитировано
6
Chemical Engineering Journal, Год журнала: 2024, Номер 488, С. 150998 - 150998
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
6
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(8), С. 4823 - 4838
Опубликована: Июль 26, 2024
Itaconic acid and its derivative 4-octyl itaconate (OI) represent a novel anti-inflammatory medication that has demonstrated efficacy in multiple inflammation models because of minimal side effects. Recently, natural polymers conjugated with small molecule drugs, known as polymer-drug conjugates (PDCs), have emerged promising approach to sustained drug release. In this work, we reported an prepare PDC containing OI make it into injectable hydrogel. Chitosan (CS) was selected for synthesis abundant free amino groups can be molecules carboxyl by carbodiimide chemistry. We used ethanol/water cosolvent system synthesize CS-OI conjugate via EDC/NHS catalysis. The had improved water solubility unique activity did not show compromised antibacterial compared unmodified CS. Beta-glycerophosphate (β-GP) cross-linked hydrogel exhibited good injectability sustainable release effectively modulated inflammatory response rat model. Therefore, study provides valuable insights the design hydrogels modulatory properties.
Язык: Английский
Процитировано
6
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Июнь 7, 2024
An injectable hydrogel formulation is developed utilizing low- and high-molecular-weight chitosan (LCH HCH) incorporated with curcumin α-tocopherol-loaded liposomes (Lip/Cur+Toc). Cur Toc releases are delayed within the hydrogels. The injectability of hydrogels proved via rheological analyses. In vitro studies conducted using human dental pulp stem cells (hDPSCs) gingival fibroblasts (hGFs) to examine biological performance toward endodontics periodontics, respectively. viability hDPSCs treated Lip/Cur+Toc highest till day 14, compared neat During odontogenic differentiation tests, alkaline phosphatase (ALP) enzyme activity induced in Cur-containing groups. Biomineralization enhanced mostly incorporation. hGFs HCH combined while wound healing occurs almost 100% both (Lip/Cur+Toc@LCH Lip/Cur+Toc@HCH) after 2 days. Antioxidant Lip/Cur+Toc@LCH on significantly among Antimicrobial tests demonstrate that more effective against Escherichia coli whereas so Lip/Cur+Toc@HCH Staphylococcus aureus. antimicrobial mechanism investigated for first time through various computational models. LCH loaded promising candidates multi-functional features periodontics.
Язык: Английский
Процитировано
5
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141115 - 141115
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Advances in Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 103496 - 103496
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0