Nano Research, Год журнала: 2024, Номер 18(2), С. 94907175 - 94907175
Опубликована: Дек. 16, 2024
Язык: Английский
Biomaterials Advances, Год журнала: 2025, Номер 169, С. 214193 - 214193
Опубликована: Янв. 18, 2025
Язык: Английский
Процитировано
2
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160592 - 160592
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)
Опубликована: Апрель 22, 2024
Chronic local inflammation and excessive cell apoptosis in nucleus pulposus (NP) tissue are the main causes of intervertebral disc degeneration (IDD). Stimuli-responsive hydrogels have great potential treatment IDD by facilitating localized controlled drug delivery. Herein, an injectable drug-loaded dual stimuli-responsive adhesive hydrogel for microenvironmental regulation IDD, is developed. The gelatin methacryloyl functionalized with phenylboronic acid groups to enhance loading capacity enable behavior, while incorporation oxidized hyaluronic further improves properties. prepared exhibits enhanced diol-containing drugs, pH- reactive oxygen species (ROS)-responsive behaviors, excellent radical scavenging efficiency, potent antibacterial activity, favorable biocompatibility. Furthermore, shows a beneficial protective efficacy on NP cells within vitro oxidative stress microenvironment. vivo results demonstrate hydrogel's therapeutic effect treating maintaining water retention, restoring height, promoting regeneration, indicating that this holds as promising approach regulating microenvironment alleviating progression IDD.
Язык: Английский
Процитировано
7
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(29)
Опубликована: Июль 22, 2024
Reactive oxygen species (ROS), as metabolic byproducts, play pivotal role in physiological and pathological processes. Recently, studies on the regulation of ROS levels for disease treatments have attracted extensive attention, mainly involving ROS-induced toxicity therapy mediated by producers antioxidant scavengers. Nanotechnology advancements led to development numerous nanomaterials with ROS-modulating capabilities, among which carbon dots (CDs) standing out noteworthy nanomedicines own their distinctive physicochemical properties, high stability, excellent biocompatibility. Despite progress treating ROS-related diseases based CDs, critical issues such rational design principles remain underexplored. The primary cause these may stem from intricate amalgamation core structure, defects, surface states, inherent poses challenges establishing a consistent generalization. This review succinctly summarizes recently ROS-modulated approaches using CDs treatment. Specifically, it investigates established therapeutic strategies CDs-regulated ROS, emphasizing interplay between intrinsic structure generation or scavenging ability. conclusion raises several unresolved key scientific prominent technological bottlenecks, explores future perspectives comprehensive CDs-based therapy.
Язык: Английский
Процитировано
7
Cell Biology and Toxicology, Год журнала: 2024, Номер 40(1)
Опубликована: Март 13, 2024
Abstract Intervertebral disc degeneration (IVDD) is an aging disease that results in a low quality of life and heavy socioeconomic burden. The mitochondrial unfolded protein response (UPR mt ) take part various aging-related diseases. Our research intents to explore the role underlying mechanism UPR IVDD. Nucleus pulposus (NP) cells were exposed IL-1β nicotinamide riboside (NR) served as inducer treat NP cells. Detection ATP, NAD + NADH used determine function mitochondria. MRI, Safranin O-fast green Immunohistochemical examination degree IVDD vivo. In this study, we discovered was increased markedly human tissues than healthy controls. vitro, mitophagy levels promoted treated with IL-1β. Upregulation by NR Atf5 overexpression inhibited cell apoptosis further improved mitophagy. Silencing Pink1 reversed protective effects induced . vivo, might attenuate IDD activating rats. summary, involved regulating Pink1-induced Mitophagy be latent target for Graphical • upregulated degenerative intervertebral disc. regulated could activate protect from apoptosis. Nicotinamide reduced apoptosis, thereby delaying process
Язык: Английский
Процитировано
6
Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155389 - 155389
Опубликована: Авг. 31, 2024
Язык: Английский
Процитировано
5
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(22), С. 28991 - 29002
Опубликована: Май 20, 2024
Triphenylphosphine functionalized carbon dots (TPP-CDs) showcase robust mitochondria targeting capacity owing to their positive electrical properties. However, TPP-CDs typically involve complicated synthesis steps and time-consuming postmodification procedures. Especially, the one-step target-oriented of regulation TPP linkage modes remain challenges. Herein, we propose a free-radical-initiated random copolymerization in combination with hydrothermal carbonation regulate backbone for triphenylphosphine (TPPcopoly-CDs). The mechanism reactions is directional, straightforward, controllable. content IC50 hydroxyl radicals scavenging ability TPPcopoly-CDs are 53 wt % 0.52 mg/mL, respectively. serves as charge control agent elevate negatively charged CDs by 20 mV. negative can target mitochondria, corresponding moiety plays crucial role mitochondria. This discovery provides new perspective on controlled synthesis, modes, mitochondrial design TPP-CDs.
Язык: Английский
Процитировано
4
Acta Biomaterialia, Год журнала: 2024, Номер 186, С. 1 - 29
Опубликована: Авг. 14, 2024
Язык: Английский
Процитировано
4
Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112718 - 112718
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 295, С. 139535 - 139535
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
0