Chemical Communications, Год журнала: 2024, Номер unknown
Опубликована: Дек. 27, 2024
A covalent organic framework-based multifunctional nanomedicine, CuO2@COF-SNO, which can produce reactive oxygen and nitrogen species (ROS/RNS) to enhance chemodynamic therapy of tumors.
Язык: Английский
ACS Materials Letters, Год журнала: 2024, Номер 6(4), С. 1160 - 1177
Опубликована: Фев. 26, 2024
The complexity of the cancer microenvironment makes it highly challenging for drugs to meet therapeutic requirements, significantly hampering their clinical translation. enormous potential intelligent materials that can act as themselves results in development smart drugless or drug-like architectures, offering synergistic effects. In this study, we demonstrate generation transition metal-based dichalcogenides (TMDCs)-based conformational (flower-like) nanoarchitectonics trimodal therapies against breast carcinoma. Initially, progressive transformation two-dimensional (2D) molybdenum selenide (MoSe2)-based nanosheets into nanoflower-like architectures by thermal injection method is observed with time. Further, these flowers are subsequently decorated an optimal amount platinum (Pt) nanoparticles nanocatalytic efficacy and surface-modified polyethylene glycol (PEG) improved biocompatibility, shortly denoted Pt-MoSe2-PEG light-assisted photothermal (PTT) photodynamic (PDT), well light-augmented chemodynamic (CDT) modalities. A series physicochemical characterizations performance validations successfully demonstrated tumor (pH/GSH)-responsive degradable structures, substantially improving ability reactive oxygen species generation, MoSe2-based PTT/PDT capability, CDT Pt nanoenzymes. Finally, vitro vivo investigations 4T1 cell line its xenograft model BALB/C mice, respectively, validated toward ablating
Язык: Английский
Процитировано
20
Advances in Colloid and Interface Science, Год журнала: 2025, Номер 339, С. 103420 - 103420
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
2
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)
Опубликована: Май 16, 2024
Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain
Язык: Английский
Процитировано
15
Environmental Pollution, Год журнала: 2024, Номер unknown, С. 125624 - 125624
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
10
Current Pharmaceutical Design, Год журнала: 2024, Номер 30(35), С. 2801 - 2812
Опубликована: Авг. 7, 2024
As cancer therapy progresses, challenges remain due to the inherent drawbacks of conventional treatments such as chemotherapy, gene therapy, radiation and surgical removal. Moreover, their associated side effects, affect both cancerous normal cells, making photodynamic (PDT) an attractive alternative.
Язык: Английский
Процитировано
7
RSC Advances, Год журнала: 2024, Номер 14(6), С. 4285 - 4300
Опубликована: Янв. 1, 2024
The deficiency of oxygen in most solid tumors plays a profound role their proliferation, metastasis, and invasion contributes to resistance treatments such as radiation, chemotherapy, photodynamic therapy (PDT). A therapeutic approach based on the Fenton reaction has received considerable interest means treating cancer with ROS-based nano catalytic medicine, referred chemodynamic (CDT). range modified treatment strategies are being explored enhance both CDT conventional methods therapy. These include Fenton-like reactions, photo-enhanced catalytic-enhanced synergistic therapies. In this article, we propose demonstrate photochemotherapy (PCT) strategy for utilizing near-infrared (NIR)-induced reactions using Fe-doped nanodiamond (FeND). When FeND is exposed human lung cells A549, it exhibits outstanding biocompatibility. However, when particle-treated NIR laser particle cytotoxicity certain degree. anticancer medication doxorubicin (DOX) was adsorbed onto address issue. conjugated DOX could undergo redox cycle generate excess H2O2 inside cells, addition, can also cause tumor cell apoptosis. Combining chemotherapy (via DOX) results enhanced effectiveness. Moreover, intrinsic fluorescence be used monitor interaction particles well localization, thus making an excellent imaging probe. our study, found that serve agent, biomarker, drug carrier, potentially valuable candidate agents contribute further development more effective platforms nanodiamond.
Язык: Английский
Процитировано
5
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(33), С. 23497 - 23507
Опубликована: Авг. 8, 2024
Tailormade bottom-up synthesis of covalent organic frameworks (COFs) from various functional building blocks offer not only tunable topology and pore size but also multidimensional properties. High crystallinity is one the prerequisites for their structures associated physicochemical Among different π-conjugated motifs constructing COFs, pyrene-based tetragonal are effective in achieving highly ordered crystalline states. In present research, we demonstrated that substitution pyrene with 2,7-diazapyrene produces nearly "flat" two-dimensional (2D) COF layers by controlling torsional angle linker molecules. Featuring finite diameters excellent thermodynamic stability ∼500 °C, face-to-face (slipped AA) stacking arrangements were produced. Extended electrical conjugation spanning 2D frames modest optical bandgaps (Eg) ∼2.1 eV shows planar character diazapyrene-based COFs. The conjugated small Eg values beneficial formation stable conducting pathways state, which was confirmed results microwave conductivity measurements. Nitrogen centers diazapyrene units play a key role as active sites proton transfer, maximum σ = 10–2 S cm–1 achieved along cocontinuous nanopore surrounded sites. Results show COFs based on can be used material special proton-conducting capabilities.
Язык: Английский
Процитировано
5
Small, Год журнала: 2024, Номер unknown
Опубликована: Июнь 3, 2024
Abstract The extracellular matrix (ECM) engages in regulatory interactions with cell surface receptors through its constituent proteins and polysaccharides. Therefore, nano‐sized conjugated doxorubicin (DOX) is utilized to produce matrix‐drug conjugates (ECM‐DOX) tailored for targeted delivery cancer cells. ECM‐DOX nanoparticles exhibit rod‐like morphology, boasting a commendable drug loading capacity of 4.58%, coupled acid‐sensitive release characteristics. Notably, enhance the uptake by tumor cells possess ability penetrate endothelial infiltrate multicellular spheroids. Mechanistic insights reveal that internalization nanoparticle facilitated clathrin‐mediated endocytosis macropinocytosis, intricately involving hyaluronic acid integrins. Pharmacokinetic assessments unveil prolonged blood half‐life at 3.65 h, substantial improvement over 1.09 h observed free DOX. A sustained accumulation effect sites, levels tissues surpassing those DOX several‐fold. profound therapeutic impact evident their notable inhibition growth, extension median survival time animals, significant reduction DOX‐induced cardiotoxicity. ECM platform emerges as promising carrier avant‐garde nanomedicines realm treatment.
Язык: Английский
Процитировано
4
FlatChem, Год журнала: 2025, Номер unknown, С. 100849 - 100849
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 20, 2025
Transition metal dichalcogenides (TMDs) have emerged as groundbreaking materials in the field of biomedical applications, particularly development biosensors and medical devices. Their unique electronic optical properties, combined with their tunability biocompatibility, position TMDs promising candidates for enhancing early disease detection enabling personalized medicine. This perspective explores multifaceted potential TMDs, highlighting applications fluorescence Raman-based biosensing, wearable implantable devices, smart therapeutic systems targeted treatment. Additionally, we address critical challenges such regulatory hurdles, long-term stability, ethical considerations surrounding continuous health monitoring data privacy. Looking to future, envision playing a vital role advancement precision medicine, facilitating real-time individualized treatments. However, successful integration into clinical practice necessitates interdisciplinary collaboration among science, bioengineering, By fostering collaboration, can fully harness capabilities revolutionize healthcare, making it more accessible, precise, patients worldwide.
Язык: Английский
Процитировано
0