Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 156545 - 156545
Опубликована: Окт. 10, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 156545 - 156545
Опубликована: Окт. 10, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 154203 - 154203
Опубликована: Июль 21, 2024
Язык: Английский
Процитировано
10Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
1Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113580 - 113580
Опубликована: Фев. 28, 2025
Язык: Английский
Процитировано
1Biosensors and Bioelectronics, Год журнала: 2024, Номер 264, С. 116668 - 116668
Опубликована: Авг. 12, 2024
Язык: Английский
Процитировано
5ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 11, 2025
Sublethal tumor cells have an urgent need for energy, making it common them to switch metabolic phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) compensatory energy supply; thus, the synchronous interference of dual pathways limiting level is essential in inhibiting sublethal growth. Herein, a multifunctional nanoplatform Co-MOF-loaded anethole trithione (ADT) myristyl alcohol (MA), modified with GOx hyaluronic acid (HA) was developed, namely, CAMGH. It could synchronously interfere including OXPHOS restrict adenosine triphosphate (ATP) supply, achieving inhibition tumors after microwave (MW) thermal therapy. Under low-power MW irradiation, CAMGH induced certain damage while ensuring safety surrounding normal tissues. The loaded consumed glucose tumors, undoubtedly blocking main supply pathway, glycolytic pathway. Then, H
Язык: Английский
Процитировано
0Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
NIR-II-triggered phototherapy presents a noninvasive, resistance-free alternative therapeutic approach with deeper tissue penetration and improved imaging of deep tumors. However, many NIR-II phototherapeutic agents suffer from low fluorescence quantum yields, poor photothermal conversion efficiency (PCE), reduced efficacy due to the upregulation heat shock protein HSP70. This study develops small-molecule agent (IRF) high yield (17.4%), excellent PCE (96.8%) for therapy (PTT), photodynamic (PDT) activity. To decrease thermal resistance during phototherapy, IRF evodiamine (EVO) were loaded onto hyaluronic acid (HA)-modified nanoparticles, creating multifunctional nanoplatform termed EVO/IRF@HA NPs. NPs can actively target tumors via HA moiety. Upon 980 nm laser irradiation, increases temperature content reactive oxygen species synergistic PTT/PDT. Importantly, EVO effectively inhibits overexpression HSP70, enabling combined PTT/PDT/chemotherapy effective colorectal cancer (CRC) treatment.
Язык: Английский
Процитировано
0Bioactive Materials, Год журнала: 2025, Номер 50, С. 540 - 555
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Май 14, 2025
Язык: Английский
Процитировано
0Journal of Colloid and Interface Science, Год журнала: 2024, Номер 678, С. 1060 - 1074
Опубликована: Авг. 31, 2024
Язык: Английский
Процитировано
2Biomaterials Science, Год журнала: 2024, Номер 12(16), С. 4083 - 4102
Опубликована: Янв. 1, 2024
Hydrogen peroxide (H 2 O ) as a reactive oxygen species produced by cellular metabolism can be used in antitumor therapy.
Язык: Английский
Процитировано
1