Coordination engineering of FeCo dual single-atom nanozymes with photothermal-enhanced cascaded catalysis for efficient pancreatic cancer immunotherapy

Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 154203 - 154203

Опубликована: Июль 21, 2024

Язык: Английский

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Nanomedicine-driven tumor glucose metabolic reprogramming for enhanced cancer immunotherapy

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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sEmerging glucose oxidase-delivering nanomedicines for enhanced tumor therapy

Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113580 - 113580

Опубликована: Фев. 28, 2025

Язык: Английский

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Predicting anti-tumor efficacy of multi-functional nanomedicine on decellularized hepatocellular carcinoma-on-a-chip

Biosensors and Bioelectronics, Год журнала: 2024, Номер 264, С. 116668 - 116668

Опубликована: Авг. 12, 2024

Язык: Английский

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Synchronous Interference of Dual Metabolic Pathways Mediated by H₂S Gas/GOx for Augmenting Tumor Microwave Thermal Therapy

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Sublethal tumor cells have an urgent need for energy, making it common them to switch metabolic phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) compensatory energy supply; thus, the synchronous interference of dual pathways limiting level is essential in inhibiting sublethal growth. Herein, a multifunctional nanoplatform Co-MOF-loaded anethole trithione (ADT) myristyl alcohol (MA), modified with GOx hyaluronic acid (HA) was developed, namely, CAMGH. It could synchronously interfere including OXPHOS restrict adenosine triphosphate (ATP) supply, achieving inhibition tumors after microwave (MW) thermal therapy. Under low-power MW irradiation, CAMGH induced certain damage while ensuring safety surrounding normal tissues. The loaded consumed glucose tumors, undoubtedly blocking main supply pathway, glycolytic pathway. Then, H

Язык: Английский

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Development of a Highly Efficient NIR-II Phototherapeutic Agent for Fluorescence Imaging-Guided Synergistic PTT/PDT/Chemotherapy of Colorectal Cancer

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

NIR-II-triggered phototherapy presents a noninvasive, resistance-free alternative therapeutic approach with deeper tissue penetration and improved imaging of deep tumors. However, many NIR-II phototherapeutic agents suffer from low fluorescence quantum yields, poor photothermal conversion efficiency (PCE), reduced efficacy due to the upregulation heat shock protein HSP70. This study develops small-molecule agent (IRF) high yield (17.4%), excellent PCE (96.8%) for therapy (PTT), photodynamic (PDT) activity. To decrease thermal resistance during phototherapy, IRF evodiamine (EVO) were loaded onto hyaluronic acid (HA)-modified nanoparticles, creating multifunctional nanoplatform termed EVO/IRF@HA NPs. NPs can actively target tumors via HA moiety. Upon 980 nm laser irradiation, increases temperature content reactive oxygen species synergistic PTT/PDT. Importantly, EVO effectively inhibits overexpression HSP70, enabling combined PTT/PDT/chemotherapy effective colorectal cancer (CRC) treatment.

Язык: Английский

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Enhanced sequential osteosarcoma therapy using a 3D-Printed bioceramic scaffold combined with 2D nanosheets via NIR-II photothermal-chemodynamic synergy

Bioactive Materials, Год журнала: 2025, Номер 50, С. 540 - 555

Опубликована: Май 1, 2025

Язык: Английский

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Visualization of HSP70-regulated mild-photothermal therapy for synergistic tumor treatment: a precise space-time mild-temperature photothermal ablation strategy

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Май 14, 2025

Язык: Английский

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Redox homeostasis disruptors enhanced cuproptosis effect for synergistic photothermal/chemodynamic therapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 678, С. 1060 - 1074

Опубликована: Авг. 31, 2024

Язык: Английский

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Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Biomaterials Science, Год журнала: 2024, Номер 12(16), С. 4083 - 4102

Опубликована: Янв. 1, 2024

Hydrogen peroxide (H 2 O ) as a reactive oxygen species produced by cellular metabolism can be used in antitumor therapy.

Язык: Английский

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