Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Chemical Society Reviews, Год журнала: 2018, Номер 48(7), С. 2053 - 2108

Опубликована: Сен. 27, 2018

The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis cancer, respectively. By taking advantage nanocarriers, both imaging therapeutic functions together with enhanced tumour accumulation have thoroughly studied to improve pre-clinical efficiency PAI PTT. In this review, we first summarize development inorganic organic nano photothermal transduction agents (PTAs) strategies improving PTT outcomes, including applying appropriate laser dosage, guiding via techniques, developing PTAs absorption in second NIR window, increasing (PCE), also tumours. Second, introduce advantages combining other therapies cancer treatment. Third, emerging applications cancer-related research are exemplified. Finally, perspectives challenges combating especially regarding their clinical translation, discussed. We believe that having noteworthy features would become promising next-generation non-invasive theranostic techniques our ability combat cancers.

Язык: Английский

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Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

Chemical Society Reviews, Год журнала: 2018, Номер 48(1), С. 38 - 71

Опубликована: Ноя. 2, 2018

Recent progress in developing organic semiconducting materials (OSMs) for deep-tissue optical imaging, cancer phototherapy and biological photoactivation is summarized.

Язык: Английский

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Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Год журнала: 2023, Номер 123(11), С. 6891 - 6952

Опубликована: Май 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Язык: Английский

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Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(35), С. 14789 - 14804

Опубликована: Авг. 7, 2020

Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital capacity in the conventional wavelength range (400–950 nm) been restricted by extremely limited tissue penetration. To tackle this challenge, novel approach using fluorescence second near-infrared window (NIR-II, 1000–1700 developed past decade to achieve deep penetration and high-fidelity imaging, thus significant applications have begun emerge. In Perspective, we first examine recent discoveries challenges development of NIR-II fluorophores compatible apparatuses. Subsequently, advances bioimaging, biosensing, therapy such cutting-edge technique are highlighted. Finally, based on achievement representative studies, elucidate main concerns regarding give some advice prospects future applications.

Язык: Английский

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Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Год журнала: 2020, Номер 50(2), С. 1111 - 1137

Опубликована: Ноя. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Язык: Английский

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Design of superior phototheranostic agents guided by Jablonski diagrams

Chemical Society Reviews, Год журнала: 2020, Номер 49(22), С. 8179 - 8234

Опубликована: Янв. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Язык: Английский

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Emerging combination strategies with phototherapy in cancer nanomedicine

Chemical Society Reviews, Год журнала: 2020, Номер 49(22), С. 8065 - 8087

Опубликована: Янв. 1, 2020

Based on the challenges in single-mode phototherapy, this review summarizes significant research progress combinatorial strategies with phototherapy.

Язык: Английский

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Optical nano-agents in the second near-infrared window for biomedical applications

Chemical Society Reviews, Год журнала: 2018, Номер 48(1), С. 22 - 37

Опубликована: Ноя. 16, 2018

This review summarizes the recent advances of optical nano-agents for various biomedical applications in NIR-II window.

Язык: Английский

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Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics

Advanced Materials, Год журнала: 2018, Номер 30(49)

Опубликована: Июль 29, 2018

Optical imaging has played a pivotal role in biology and medicine, but it faces challenges of relatively low tissue penetration poor signal-to-background ratio due to light scattering autofluorescence. To overcome these issues, second near-infrared fluorescence, self-luminescence, photoacoustic have recently emerged, which utilize an optical region with reduced light-tissue interactions, eliminate real-time excitation, detect acoustic signals negligible attenuation, respectively. Because there are only few endogenous molecules absorbing or emitting above the visible region, development contrast agents is essential for those deep-tissue modalities. Organic semiconducting π-conjugated frameworks can be synthesized meet different requirements their easy chemical modification legible structure-property relation. Herein, applications organic including small-molecule nanoparticle derivatives summarized. In particular, molecular engineering nanoformulation approaches further improve detection sensitivity modalities highlighted. Finally, current potential opportunities this emerging subfield biomedical discussed.

Язык: Английский

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Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging

Chemical Science, Год журнала: 2018, Номер 9(19), С. 4370 - 4380

Опубликована: Янв. 1, 2018

In recent years, owing to unsatisfactory clinical imaging clarity and depths in the living body for early diagnosis prognosis, novel modalities with high bioimaging performance have been actively explored. The remarkable headway made second near-infrared region (NIR-II, 1000-1700 nm) has promoted development of biomedical significantly. NIR-II fluorescence possesses a number merits which prevail over traditional NIR-I (400-900 fundamental research, such as reduced photon scattering, well auto-fluorescence improved penetration depth. Functional probes instant precise feedback vivo information are at core this modality superb imaging. Herein, we review recently developed fluorophores including carbon nanotubes, organic small molecules, quantum dots, conjugated polymers rare-earth-doped materials present superior multifunctionality regions (1000-1700 nm).

Язык: Английский

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