Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Advanced Materials, Год журнала: 2019, Номер 31(24)

Опубликована: Апрель 26, 2019

Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target variety of biological tissues processes. This review focuses on summarizing organic dyes emitting at transparency window termed the near-infrared-II (NIR-II) window, where minimal light interaction with surrounding allows photons travel nearly unperturbed throughout body. NIR-II fluorescence imaging overcomes penetration/contrast bottleneck in visible region, making it remarkable modality early diagnosis cancer highly sensitive tumor surgery. Due their convenient bioconjugation peptides/antibodies, molecular are desirable candidates targeted imaging, significantly overcoming autofluorescence/scattering issues deep tissue imaging. To promote clinical translation bioimaging, advancements high-performance small molecule-derived probes critically important. Here, molecules potential discussed, synthesis chemical structures dyes, optical properties behavior whole body detection surgery, as well microscopy A key perspective direction surgery is also discussed.

Язык: Английский

---

Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(30), С. 16294 - 16308

Опубликована: Авг. 12, 2020

The development of fluorophores for the second near-infrared window (NIR-II, 1000-1700 nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical biology, biomedical engineering. wavelength, brightness, stability are three crucial factors that determine performance NIR-II fluorophore. Up to now, significant progress has been made fluorescence molecular probes, including synthesis D-A-D D-π-A with improved imaging construction off-on probes ratiometric via energy transfer or structure modification. In this review, we summarize most recent advances engineering design strategies then highlight a selection bioimaging biosensing applications. We also provide perspectives on potential challenges opportunities emerging field.

Язык: Английский

---

Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Март 5, 2019

Abstract The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating the second near-infrared window (NIR-II; 1000-1700 nm), but an ongoing challenge is solvatochromism-caused quenching aqueous solution for long-wavelength absorbing fluorophores. Herein, we develop a series anti-quenching pentamethine cyanine that significantly overcome severe solvatochromism, thus affording stable absorption/emission beyond 1000 nm with up to ~ 44-fold enhanced brightness superior photostability solution. These advantages allow deep optical penetration (8 mm) as well high-contrast highly-stable lymphatic clinical-approved indocyanine green. Additionally, these exhibit pH-responsive fluorescence, allowing noninvasive ratiometric quantification gastric pH vivo. results demonstrate reliable accuracy tissue 4 mm, comparable standard electrode method. This work unlocks potential cyanines NIR-II biological applications.

Язык: Английский

---

Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Год журнала: 2021, Номер 122(1), С. 209 - 268

Опубликована: Окт. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Язык: Английский

---

NIR‐II AIEgens: A Win–Win Integration towards Bioapplications

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(14), С. 7476 - 7487

Опубликована: Июнь 9, 2020

Fluorescence imaging in the second near-infrared (NIR-II) window facilitated by aggregation-induced emission luminogens (AIEgens) is an emerging research field. NIR-II AIEgens overcome limitations imposed penetration depth and fluorescence efficiency, offering high-performance with enhanced precision. Some reported demonstrate capabilities for photoacoustic bimodal imaging, guided photothermal therapy, which not only improves diagnosis accuracy but provides efficient theranostic platform to accelerate preclinical translation as well. This minireview summarizes recent efforts on exploiting regard molecular design strategies bioapplications, puts forward current challenges promising prospects. timely sketch should benefit further exploitation of diverse multifunctional a wide array applications.

Язык: Английский

---

All‐in‐One Phototheranostics: Single Laser Triggers NIR‐II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy

Advanced Functional Materials, Год журнала: 2019, Номер 29(31)

Опубликована: Май 23, 2019

Abstract Development of single near‐infrared (NIR) laser triggered phototheranostics for multimodal imaging guided combination therapy is highly desirable but still a big challenge. Herein, novel small‐molecule dye DPP‐BT designed and synthesized, which shows strong absorption in the first NIR window (NIR‐I) fluorescence emission second region (NIR‐II). Such not only acts as dual‐modal contrast agent NIR‐II photoacoustic (PA) imaging, also serves combined therapeutic photothermal (PTT) photodynamic (PDT). The all‐in‐one phototheranostic nanoparticles are constructed by encapsulating DPP‐BT, chemotherapy drug DOX, natural phase‐change materials with folic acid functionalized amphiphile. Notably, under irradiation, DOX can effectively release from such via NIR‐induced hyperthermia DPP‐BT. By intravenous injection into Hela tumor‐bearing mice, tumor size location be accurately observed fluorescence/PA imaging. From vitro vivo results, simultaneously present remarkable antitumor efficacy PTT/PDT/chemo therapy, laser. Overall, this work provides an innovative strategy to design construct nanoplatforms clinical phototheranostics.

Язык: Английский

---

Functional synthetic probes for selective targeting and multi-analyte detection and imaging

Chemical Society Reviews, Год журнала: 2019, Номер 48(15), С. 4155 - 4177

Опубликована: Янв. 1, 2019

Probes with multiple interaction sites or single promoting tandem reactions target challenging analytes and enable the visualization of in vivo interactions.

Язык: Английский

---

Recent advances in near-infrared emitting lanthanide-doped nanoconstructs: Mechanism, design and application for bioimaging

Coordination Chemistry Reviews, Год журнала: 2018, Номер 381, С. 104 - 134

Опубликована: Дек. 10, 2018

Язык: Английский

---

Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Май 17, 2019

Fluorophores with donor-acceptor-donor groups the emission spanning second near-infrared window (NIR-II) have recently received great attention for biomedical application. Yet, mechanism underlying equilibrium between fluorescence (radiative decay) and photothermal effect (non-radiative of these fluorophores remains elusive. Here, we demonstrate that a lipophilic NIR-II fluorophore, BPBBT, possesses both twisted intramolecular charge transfer (TICT) aggregation-induced (AIE) characteristics. Human serum albumin (HSA) binds to which changes planarity fluorophore restricts its rotation. The binding results in alteration AIE TICT state tailoring efficiency. Under guidance intraoperative image, prepared HSA-bound BPBBT nanoparticles delineate primary orthotopic mouse colon tumor metastatic lesions dimensions as small 0.5 mm × 0.3 mm, offer ablation therapy optimized timing, dosing area laser irradiation.

Язык: Английский

---

Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging

Chemical Reviews, Год журнала: 2021, Номер 121(15), С. 9243 - 9358

Опубликована: Июль 20, 2021

Research related to the development and application of luminescent nanoparticles (LNPs) for chemical biological analysis imaging is flourishing. Novel materials new applications continue be reported after two decades research. This review provides a comprehensive heuristic overview this field. It targeted both newcomers experts who are interested in critical assessment LNP materials, their properties, strengths weaknesses, prospective applications. Numerous cataloged by fundamental descriptions identities physical morphology, quantitative photoluminescence (PL) PL mechanisms, surface chemistry. These include various semiconductor quantum dots, carbon nanotubes, graphene derivatives, nanodiamonds, metal nanoclusters, lanthanide-doped upconversion downshifting nanoparticles, triplet–triplet annihilation persistent-luminescence conjugated polymer semiconducting multi-nanoparticle assemblies, doped labeled including but not limited those based on polymers silica. As an exercise these ranked several application-related functional criteria. Additional sections highlight recent examples advances analysis, point-of-care diagnostics, cellular, tissue, vivo theranostics. drawn from literature organized material particular properties that leveraged advantage. Finally, perspective what comes next field offered.

Язык: Английский

---