Cancer nanomedicine for combination cancer immunotherapy

Nature Reviews Materials, Год журнала: 2019, Номер 4(6), С. 398 - 414

Опубликована: Апрель 26, 2019

Язык: Английский

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Recent progress of chemodynamic therapy-induced combination cancer therapy

Nano Today, Год журнала: 2020, Номер 35, С. 100946 - 100946

Опубликована: Авг. 13, 2020

Язык: Английский

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Inorganic nanomaterials with rapid clearance for biomedical applications

Chemical Society Reviews, Год журнала: 2021, Номер 50(15), С. 8669 - 8742

Опубликована: Янв. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Язык: Английский

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Two-dimensional molecular brush-functionalized porous bilayer composite separators toward ultrastable high-current density lithium metal anodes

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Март 25, 2019

Abstract Lithium metal batteries have been considerably limited by the problems of uncontrolled dendritic lithium formation and highly reactive nature with electrolytes. Herein, we developed functional porous bilayer composite separators simply blade-coating polyacrylamide-grafted graphene oxide molecular brushes onto commercial polypropylene separators. Our integrate lithiophilic feature hairy polyacrylamide chains fast electrolyte diffusion pathways excellent mechanical strength nanosheets thus enable molecular-level homogeneous ionic flux on surfaces electrodes. As a result, dendrite-free uniform deposition high Coulombic efficiency (98%) ultralong-term reversible plating/stripping (over 2600 h) at current density (2 mA cm −2 ) are achieved for anodes. Remarkably, anodes an unprecedented stability more than 1900 h cycling ultrahigh 20 demonstrated.

Язык: Английский

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Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy

ACS Nano, Год журнала: 2021, Номер 15(5), С. 8039 - 8068

Опубликована: Май 11, 2021

Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has been observed in many cancer cells, solid evidence corroborated resulting tumor a variety anticancer therapies, suggesting that this biochemical characteristic can be developed as potential target for treatments. The single treatment GSH-depleting agents potentiate responses different cell death stimuli; therefore, an adjunctive strategy, GSH depletion is usually combined with mainstream therapies enhancing Propelled by rapid development nanotechnology, readily constructed into nanomedicines, have shown steep rise over past decade. Here, we review common nanomedicines widely applied synergistic treatments recent years. Some current challenges future perspectives depletion-based are also presented. With understanding structure–property relationship action mechanisms these biomaterials, hope nanotechnology will further realize more effective disease even achieve successful clinical translations.

Язык: Английский

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<p>Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy</p>

International Journal of Nanomedicine, Год журнала: 2020, Номер Volume 15, С. 9407 - 9430

Опубликована: Ноя. 1, 2020

Abstract: The rapid development of nanotechnology offers a variety potential therapeutic strategies for cancer treatment. High atomic element nanomaterials are often utilized as radiosensitizers due to their unique photoelectric decay characteristics. Among them, gold nanoparticles (GNPs) one the most widely investigated and considered be an ideal radiotherapy high X-ray absorption physicochemical properties. Over last few decades, multi-disciplinary studies have focused on design optimization GNPs achieve greater dosing capability higher effects highlight mechanisms radiosensitization GNPs. Although radiosensitizing has been recognized, its clinical translation still faces many challenges. This review analyses different roles in summarizes recent advances. In addition, underlying GNP radiosensitization, including physical, chemical biological discussed, which may provide new directions transformation next-generation Keywords: nanoparticles, radiotherapy,

Язык: Английский

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Cancer nanotechnology: current status and perspectives

Nano Convergence, Год журнала: 2021, Номер 8(1)

Опубликована: Ноя. 2, 2021

Modern medicine has been waging a war on cancer for nearly century with no tangible end in sight. Cancer treatments have significantly progressed, but the need to increase specificity and decrease systemic toxicities remains. Early diagnosis holds key improving prognostic outlook patient quality of life, diagnostic tools are cusp technological revolution. Nanotechnology steadily expanded into reaches chemotherapy, radiotherapy, diagnostics, imaging, demonstrating capacity augment each advance care. Nanomaterials provide an abundance versatility, functionality, applications engineer specifically targeted medicine, accurate early-detection devices, robust imaging modalities, enhanced radiotherapy adjuvants. This review provides insights current clinical pre-clinical nanotechnological drug therapy, radiation therapy.

Язык: Английский

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Multifunctional Graphdiyne–Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer

Advanced Materials, Год журнала: 2021, Номер 33(24)

Опубликована: Май 5, 2021

Abstract Radioresistance is an important challenge for clinical treatments. The main causes of radioresistance include hypoxia in the tumor microenvironment, antioxidant system within cancer cells, and upregulation DNA repair proteins. Here, a multiple radiosensitization strategy high‐ Z ‐element‐based radiation enhancement designed, attenuating microRNA therapy. novel 2D graphdiyne (GDY) can firmly anchor disperse CeO 2 nanoparticles to form GDY–CeO nanocomposites, which exhibit superior catalase‐mimic activity decomposing H O significantly alleviate hypoxia, promote radiation‐induced damage, ultimately inhibit growth vivo. miR181a‐2‐3p (miR181a) serum levels patients are predictive response preoperative radiotherapy locally advanced esophageal squamous cell carcinoma (ESCC) facilitate personalized treatment. Moreover, miR181a act as radiosensitizer by directly targeting RAD17 regulating Chk2 pathway. Subsequently, nanocomposites with conjugated iRGD‐grafted polyoxyethylene glycol (short nano‐miR181a), increase stability, efficiently deliver tumor, low toxicity. Notably, nano‐miR181a overcome enhance therapeutic efficacy both subcutaneous model human‐patient‐derived xenograft models. Overall, this nanozyme miR181a‐based multisensitized provides promising approach ESCC.

Язык: Английский

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Enhanced Generation of Non-Oxygen Dependent Free Radicals by Schottky-type Heterostructures of Au–Bi₂S₃ Nanoparticles via X-ray-Induced Catalytic Reaction for Radiosensitization

ACS Nano, Год журнала: 2019, Номер 13(5), С. 5947 - 5958

Опубликована: Апрель 10, 2019

Despite the development of nanomaterials with high-Z elements for radiosensitizers, most them suffer from their oxygen-dependent behavior in hypoxic tumor, nonideal selectivity to or inevasible damages normal tissue, greatly limiting further applications. Herein, we develop a Schottky-type heterostructure Au-Bi2S3 promising ability reactive free radicals generation under X-ray irradiation selectively enhancing radiotherapeutic efficacy by catalyzing intracellular H2O2 tumor. On one hand, like many other rich elements, can deposit higher radiation dose within tumors form high energy electrons. remarkably improve utilization large number X-ray-induced low electrons during radiotherapy nonoxygen dependent even condition. This feature heterostructures attributes generated Schottky barrier between metal Au and semiconductor Bi2S3, which trap X-ray-generated transfer Au, resulting efficient separation electron-hole pairs. Then, because matched potential conduction band Bi2S3 overexpressed HNSCs decompose into highly toxic •OH selective radiosensitization As consequence, this kind nanoparticle provides an idea rational designed as radiosensitizers enhanced cancer.

Язык: Английский

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Smart materials for drug delivery and cancer therapy

View, Год журнала: 2020, Номер 2(2)

Опубликована: Дек. 4, 2020

Abstract Until now, enormous smart materials have been engineered with endogenous stimulators such as pH, reactive oxygen species, glutathione, hypoxia and enzyme, or exogenous temperature, light, ultrasound, radiation, magnetic field in drug delivery. As footstone of stimuli‐responsive nanocarriers, endogenous/exogenous responsive possess many properties, responding ability to specific triggers, controlled release, long blood circulation, increased tumor accumulation, “ON‐OFF” switch activities, enhanced diagnostic accuracy, therapeutic efficacy. Smart attracted considerable attention because they provide likelihood strategy for individualized comprehensive therapy. In this review, significant research achievements different triggers including their synthesis formulation mechanism, applications, multiple functions are summarized discussed separately. We primarily focus on the studies past few years (2017‐2020). The current situation remaining challenges stimuli‐sensitive materials‐based nanocarriers clinical translation rationally at end. It is hope that timely overall review would some helpful information researchers field.

Язык: Английский

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