Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

Chemical Society Reviews, Год журнала: 2020, Номер 50(2), С. 1188 - 1218

Опубликована: Дек. 7, 2020

We review the general principle of design and functional modulation nanoscaled MOF heterostructures, biomedical applications in enhanced therapy.

Язык: Английский

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Aggregation-Induced Emission Photosensitizers: From Molecular Design to Photodynamic Therapy

Journal of Medicinal Chemistry, Год журнала: 2020, Номер 63(5), С. 1996 - 2012

Опубликована: Фев. 10, 2020

Photodynamic therapy (PDT) has emerged as a promising noninvasive treatment option for cancers and other diseases. The key factor that determines the effectiveness of PDT is photosensitizers (PSs). Upon light irradiation, PSs would be activated, produce reactive oxygen species (ROS), induce cell death. One challenges traditional adopt large flat disc-like structure, which tend to interact with adjacent molecules through strong π-π stacking reduces their ROS generation ability. Aggregation-induced emission (AIE) twisted configuration suppress intermolecular interactions represent new class image-guided PDT. In this Miniperspective, we summarize recent progress on design rationale AIE-PSs strategies achieve desirable theranostic applications in cancers. Subsequently, approaches combining AIE-PS imaging modalities, challenges, future directions are addressed.

Язык: Английский

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Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(23), С. 12682 - 12705

Опубликована: Июль 16, 2020

Immunotherapy that harnesses the power of immune system to eliminate malignant cells has offered an effective approach for cancer treatment. However, limited patient response rates and potential immune-related adverse events exist as two major issues immunotherapy. In parallel, a variety electromagnetic nanomaterials generate heat and/or reactive oxygen species triggered by energy have been applied magnetic hyperthermia therapy, sonodynamic photothermal photodynamic radiotherapy, which ability induce immunogenic cell death. This review summarizes recent development nanomedicines in combinational The mechanisms reprogramming immunosuppressive tumor microenvironment sensitizing tumors immunotherapy are highlighted. Furthermore, challenges perspectives discussed.

Язык: Английский

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Fusiform-Like Copper(II)-Based Metal–Organic Framework through Relief Hypoxia and GSH-Depletion Co-Enhanced Starvation and Chemodynamic Synergetic Cancer Therapy

ACS Applied Materials & Interfaces, Год журнала: 2020, Номер 12(15), С. 17254 - 17267

Опубликована: Март 31, 2020

The therapeutic effect of traditional chemodynamic therapy (CDT) agents is severely restricted by their weakly acidic pH and glutathione (GSH) overexpression in the tumor microenvironment. Here, fusiform-like copper(II)-based tetrakis(4-carboxy phenyl)porphyrin (TCPP) nanoscale metal–organic frameworks (nMOFs) were designed constructed for first time (named PCN-224(Cu)-GOD@MnO2). coated MnO2 layer can not only avoid conjugation glucose oxidase (GOD) to damage normal cells but also catalyzes generation O2 from H2O2 enhance oxidation (Glu) GOD, which provides abundant subsequent Cu+-based Fenton-like reaction. Meanwhile, Cu2+ chelated TCPP ligand converted Cu+ excess GSH tumor, reduces antioxidant activity improve CDT effect. Next, reacts with plentiful enzyme catalysis produce a toxic hydroxyl radical (•OH), singlet oxygen (1O2) synchronously generated combination Cu+, O2, H2O via Russell mechanism. Furthermore, nanoplatform be used both TCPP-based vivo fluorescence imaging Mn2+-induced T1-weighted magnetic resonance imaging. In conclusion, PCN-224(Cu)-GOD@MnO2 nMOFs facilitate efficiency starvation relief hypoxia depletion after acting as an accurate guide.

Язык: Английский

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Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy

Biomaterials, Год журнала: 2022, Номер 282, С. 121433 - 121433

Опубликована: Фев. 19, 2022

Язык: Английский

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Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Advanced Materials, Год журнала: 2019, Номер 31(49)

Опубликована: Сен. 19, 2019

Surgical resection is the primary and most effective treatment for patients with solid tumors. However, suffer from postoperative recurrence metastasis. In past years, emerging nanotechnology has led way to minimally invasive, precision intelligent oncological surgery after rapid development of invasive surgical technology. Advanced in construction nanomaterials (NMs) imaging-guided (IGS) as well surgery-assisted synergistic therapy summarized, thereby unlocking advantages multimodal IGS-assisted cancer therapy. First, mechanisms principles NMs targets are briefly introduced. Multimodal imaging based on molecular technologies provides a practical method achieve intraoperative visualization high resolution deep tissue penetration. Moreover, multifunctional synergize adjuvant (e.g., chemotherapy, immunotherapy, phototherapy) eliminate residual lesions. Finally, key issues ideal theranostic associated applications challenges clinical transformation discussed push forward further

Язык: Английский

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Cancer-Erythrocyte Hybrid Membrane-Camouflaged Magnetic Nanoparticles with Enhanced Photothermal-Immunotherapy for Ovarian Cancer

ACS Nano, Год журнала: 2021, Номер 15(12), С. 19756 - 19770

Опубликована: Дек. 3, 2021

Cell-membrane-coated nanoparticles are widely studied due to their inherent cellular properties, such as immune escape and homologous homing. A cell membrane coating can also maintain the relative stability of during circulation in a complex blood environment through encapsulation technology. In this study, we fused murine-derived ID8 ovarian cancer with red (RBC) create hybrid biomimetic (IRM), IRM camouflaged indocyanine green (ICG)-loaded magnetic (Fe

Язык: Английский

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Chemically and Biologically Engineered Bacteria‐Based Delivery Systems for Emerging Diagnosis and Advanced Therapy

Advanced Materials, Год журнала: 2021, Номер 33(38)

Опубликована: Авг. 4, 2021

Abstract Bacteria are one of the main groups organisms, which dynamically and closely participate in human health disease development. With integration chemical biotechnology, bacteria have been utilized as an emerging delivery system for various biomedical applications. Given unique features such their intrinsic biocompatibility motility, bacteria‐based systems drawn wide interest diagnosis treatment diseases, including cancer, infectious kidney failure, hyperammonemia. Notably, at interface biotechnology bacteria, many research opportunities initiated, opening a promising frontier application. Herein, current synergy design principles systems, microbial modulation, clinical translation reviewed, with special focus on advances therapy.

Язык: Английский

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Recent Advances of Cell Membrane‐Coated Nanomaterials for Biomedical Applications

Advanced Functional Materials, Год журнала: 2020, Номер 30(39)

Опубликована: Авг. 9, 2020

Abstract Surface modification of nanomaterials is essential for their biomedical applications owing to passive immune clearance and damage reticuloendothelial systems. Recently, a cell membrane‐coating technology has been proposed as an ideal approach modify its facile functionalized process good biocompatibility improving performances synthetic nanomaterials. Here, recent advances membrane‐coated are reviewed based on the main biological functions membrane in living cells. An overview introduced understand potential applications. Then, summarized, including physical barrier with selective permeability cellular communication via information transmission reception processes. Finally, perspectives challenges about discussed.

Язык: Английский

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Recent Advances in Engineered Materials for Immunotherapy‐Involved Combination Cancer Therapy

Advanced Materials, Год журнала: 2021, Номер 33(31)

Опубликована: Май 28, 2021

Abstract Immunotherapy that can activate immunity or enhance the immunogenicity of tumors has emerged as one most effective methods for cancer therapy. Nevertheless, single‐mode immunotherapy is still confronted with several critical challenges, such low immune response, tumor infiltration, and complex immunosuppression microenvironment. Recently, combination other therapeutic modalities a powerful strategy to augment outcome in fighting against cancer. In this review, recent research advances chemotherapy, phototherapy, radiotherapy, sonodynamic therapy, metabolic microwave thermotherapy are summarized. Critical challenges future direction immunotherapy‐based also discussed.

Язык: Английский

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