Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(33)

Опубликована: Март 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Язык: Английский

---

Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms

Chemical Reviews, Год журнала: 2023, Номер 123(16), С. 10135 - 10155

Опубликована: Авг. 3, 2023

Over the last few decades, various forms of regulated cell death (RCD) have been discovered and were found to improve cancer treatment. Although there are several reviews on RCD induced by photodynamic therapy (PDT), a comprehensive summary covering metal-based photosensitizers (PSs) as inducers has not yet presented. In this review, we systematically summarize works PSs that induce different types RCD, including ferroptosis, immunogenic (ICD), pyroptosis. The characteristics mechanisms each explained. At end section, reported commonalities between inducing same is emphasized, future perspectives novel discussed at review. Considering essential roles in therapy, hope review will provide stage for advances inducers.

Язык: Английский

---

State of the art advancements in sonodynamic therapy (SDT): Metal-Organic frameworks for SDT

Chemical Engineering Journal, Год журнала: 2022, Номер 449, С. 137889 - 137889

Опубликована: Июль 4, 2022

Язык: Английский

---

Carrier-Free Immunotherapeutic Nano-Booster with Dual Synergistic Effects Based on Glutaminase Inhibition Combined with Photodynamic Therapy

ACS Nano, Год журнала: 2023, Номер 17(2), С. 1583 - 1596

Опубликована: Янв. 3, 2023

The immunotherapeutic effect elicited by photodynamic therapy (PDT) is attenuated tumor defense mechanisms associated with glutamine metabolism, including the metabolic regulation of redox homeostasis and limitation immunosuppressive microenvironment (ITM). Herein, a carrier-free nanobooster C9SN dual synergistic effects was constructed self-assembly glutaminase (GLS) inhibitor compound 968 (C968) photosensitizer Chlorin e6. C968-mediated GSH deprivation through inhibiting metabolism prevented PDT-generated reactive oxygen species from being annihilated GSH, amplifying intracellular oxidative stress, which caused severe cell death also enhanced immunogenic (ICD) effect. In addition, genome-wide analysis carried out using RNA-sequencing to evaluate changes in transcriptome induced stress. Thereafter, neoantigens generated ICD promoted maturation dendritic cells, thereby recruiting activating cytotoxic T lymphocytes (CTLs). Meanwhile, remodeled ITM blocking polarize M2-type tumor-associated macrophages (TAMs) into M1-type TAMs, further recruited activated CTLs. Ultimately, this suppressed primary distant tumors. This "kill two birds one stone" strategy would shed light on enhancing immunogenicity alleviating immunosuppression improve PDT.

Язык: Английский

---

Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell

Advanced Science, Год журнала: 2023, Номер 10(22)

Опубликована: Май 31, 2023

Abstract Cancer immunotherapies have improved human health, and one among the important technologies for cancer immunotherapy is vaccine. Antigens are most components in vaccines. Generally, antigens vaccines can be divided into two categories: pre‐defined unidentified antigens. Although, loaded with predefined commonly used, vaccine mixed antigens, especially whole cells or cell lysates, a very promising approach, such obviate some limitations Their advantages include, but not limited to, inclusion of pan‐spectra (all kinds of) inducing pan‐clones specific T cells, overcoming heterogeneity cells. In this review, recent advances based on whole‐tumor either summarized. terms focus applying water‐soluble lysates as Recently, utilizing has become feasible. Considering that pre‐determined antigen‐based (mainly peptide‐based mRNA‐based) various limitations, developing alternative.

Язык: Английский

---

A mitochondria-localized iridium(iii) photosensitizer for two-photon photodynamic immunotherapy against melanoma

Chemical Science, Год журнала: 2023, Номер 14(6), С. 1461 - 1471

Опубликована: Янв. 1, 2023

Conventional photodynamic therapy mainly causes a therapeutic effect on the primary tumor through localized generation of reactive oxygen species, while metastatic tumors remain poorly affected. Complementary immunotherapy is effective in eliminating small, non-localized distributed across multiple organs. Here, we report Ir(iii) complex Ir-pbt-Bpa as highly potent immunogenic cell death inducing photosensitizer for two-photon against melanoma. can produce singlet and superoxide anion radicals upon light irradiation, causing by combination ferroptosis death. In mouse model with two physically separated melanoma tumors, although only one was irradiated, strong reduction both observed. Upon not induced immune response CD8

Язык: Английский

---

Biomaterials Facilitating Dendritic Cell‐Mediated Cancer Immunotherapy

Advanced Science, Год журнала: 2023, Номер 10(18)

Опубликована: Апрель 23, 2023

Dendritic cell (DC)-based cancer immunotherapy has exhibited remarkable clinical prospects because DCs play a central role in initiating and regulating adaptive immune responses. However, the application of traditional DC-mediated is limited due to insufficient antigen delivery, inadequate presentation, high levels immunosuppression. To address these challenges, engineered biomaterials have been exploited enhance immunotherapeutic effects. In this review, vital principal components that can effects are first introduced. The parameters considered rational design biomaterials, including targeting modifications, size, shape, surface, mechanical properties, which affect biomaterial optimization DC functions, further summarized. Moreover, recent applications various field reviewed, those serve as component delivery platforms, remodel tumor microenvironment, synergistically other antitumor therapies. Overall, present review comprehensively systematically summarizes related promotion functions; specifically focuses on advances designs for activation eradicate tumors. challenges opportunities treatment strategies designed amplify via discussed with aim inspiring translation future immunotherapies.

Язык: Английский

---

Titanium‐Based Nanoarchitectures for Sonodynamic Therapy‐Involved Multimodal Treatments

Small, Год журнала: 2023, Номер 19(12)

Опубликована: Янв. 15, 2023

Sonodynamic therapy (SDT) has considerably revolutionized the healthcare sector as a viable noninvasive therapeutic procedure. It employs combination of low-intensity ultrasound and chemical entities, known sonosensitizer, to produce cytotoxic reactive oxygen species (ROS) for cancer antimicrobial therapies. With nanotechnology, several unique nanoplatforms are introduced sonosensitizers, including, titanium-based nanomaterials, thanks their high biocompatibility, catalytic efficiency, customizable physicochemical features. Additionally, developing sonosensitizers facilitates integration SDT with other treatment modalities (for example, chemotherapy, chemodynamic therapy, photodynamic photothermal immunotherapy), hence increasing overall results. This review summarizes most recent developments in tissue engineering using titanium mediated SDT. The synthesis strategies biosafety aspects Titanium-based also discussed. Finally, various challenges prospects its further development potential clinical translation highlighted.

Язык: Английский

---

Mitochondria‐Targeted Photodynamic and Mild‐Temperature Photothermal Therapy for Realizing Enhanced Immunogenic Cancer Cell Death via Mitochondrial Stress

Advanced Functional Materials, Год журнала: 2023, Номер 33(42)

Опубликована: Июнь 24, 2023

Abstract Induction of immunogenic cell death (ICD) represents a robust therapeutic strategy for cancer treatment. However, only few ICD inducers are currently available and many them take effect based on traditional endoplasmic reticulum (ER) stress rather than mitochondrial stress. Besides, mitochondrion is closely related to ER drug delivery via targeting usually shows higher efficiency cytotoxicity that targeting, which inspires explore the cells through Herein, mito‐missile can realize not mitochondria‐targeted photodynamic therapy (PDT)/mild‐temperature photothermal (MTPTT) but also ICD‐induced immunotherapy constructed. The (termed DIH) prepared by coating dc‐IR825 (a mitochondrion‐targeting cyanine dye)‐loaded polyamidoamine dendrimer with hyaluronic acid. precisely target mitochondria produce reactive oxygen species (ROS) mild heat upon near‐infrared (NIR) light irradiation, inducing damage stress‐caused enhanced ICD. By combining PDT, MTPTT, immunotherapy, DIH efficiently inhibit tumor growth even eradicate tumors. This study develops dendrimer‐based nanoplatform realizing mitochondrion‐acting PDT/MTPTT as well stress‐induced potentiated ICD, may provide guideline designing effective in future.

Язык: Английский

---

Emerging nitric oxide gas‐assisted cancer photothermal treatment

Exploration, Год журнала: 2024, Номер 4(6)

Опубликована: Март 24, 2024

Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.

Язык: Английский

---