Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Signal Transduction and Targeted Therapy, Год журнала: 2021, Номер 6(1)

Опубликована: Дек. 16, 2021

Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) influence cell signaling cascades fate. In the past few decades, plethora pioneering studies have been implemented explore cell-hydrogel matrix interactions figure out underlying mechanisms, paving way lab-to-clinic translation hydrogel-based therapies. this review, we first introduced hydrogels their fabrication approaches concisely. Subsequently, comprehensive description deep discussion were elucidated, wherein influences different behaviors cellular events highlighted. These or included integrin clustering, focal adhesion (FA) complex accumulation activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling activation Yes-associated (YAP), catenin, etc.), compartment reorganization, gene expression, further biology modulation spreading, migration, proliferation, lineage commitment, etc.). Based them, current in vitro vivo hydrogel mainly covered diseases models, delivery protocols for tissue regeneration disease therapy, smart drug carrier, bioimaging, biosensor, conductive wearable/implantable biodevices, etc. summarized discussed. More significantly, clinical potential trials presented, accompanied which remaining challenges future perspectives field emphasized. Collectively, insights review will shed light principles new understand processes, are available providing significant indications serving broad range applications.

Язык: Английский

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Conquering the Hypoxia Limitation for Photodynamic Therapy

Advanced Materials, Год журнала: 2021, Номер 33(48)

Опубликована: Сен. 27, 2021

Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due the hypoxic nature characteristic of many solid tumors, PDT is frequently limited therapeutic effect. Moreover, consumption O2 during may further aggravate tumor condition, which promotes proliferation, metastasis, invasion resulting poor prognosis treatment. Therefore, numerous efforts have been made increase content with goal enhancing efficacy. Herein, these strategies developed past decade are comprehensively reviewed alleviate hypoxia, including 1) delivering exogenous directly, 2) generating situ, 3) reducing cellular by inhibiting respiration, 4) regulating TME, (e.g., normalizing vasculature or disrupting extracellular matrix), 5) hypoxia-inducible factor 1 (HIF-1) signaling pathway relieve hypoxia. Additionally, -independent Type-I also discussed as an alternative strategy. By reviewing progress, it hoped that this review will provide innovative perspectives new nanomaterials designed combat hypoxia avoid associated limitation PDT.

Язык: Английский

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A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu₂MoS₄ for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

Advanced Materials, Год журнала: 2019, Номер 31(51)

Опубликована: Ноя. 4, 2019

The unique tumor microenvironment (TME) facilitates cancer proliferation and metastasis, it is hard to cure completely via monotherapy. Herein, a multifunctional cascade bioreactor based on hollow mesoporous Cu2 MoS4 (CMS) loaded with glucose oxidase (GOx) constructed for synergetic therapy by chemo-dynamic (CDT)/starvation therapy/phototherapy/immunotherapy. CMS harboring multivalent elements (Cu1+/2+ , Mo4+/6+ ) exhibit Fenton-like, glutathione (GSH) peroxidase-like catalase-like activity. Once internalized into the tumor, could generate ·OH CDT Fenton-like reaction deplete overexpressed GSH in TME alleviate antioxidant capability of tumors. Moreover, under hypoxia TME, react endogenous H2 O2 activating catalyzed oxidation GOx starvation accompanied regeneration . regenerated can devote realizing GOx-catalysis-enhanced CDT. Meanwhile, 1064 nm laser irradiation shows remarkable tumor-killing ability phototherapy due its excellent photothermal conversion efficiency (η = 63.3%) cytotoxic superoxide anion (·O2- generation performance. More importantly, PEGylated CMS@GOx-based synergistic combined checkpoint blockade elicit robust immune responses both effectively ablating primary tumors inhibiting metastasis.

Язык: Английский

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Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies

Chemical Society Reviews, Год журнала: 2021, Номер 50(16), С. 9152 - 9201

Опубликована: Янв. 1, 2021

Photodynamic therapy (PDT) has been extensively investigated for decades tumor treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and immune activation ability.

Язык: Английский

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Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

Theranostics, Год журнала: 2021, Номер 12(1), С. 434 - 458

Опубликована: Дек. 15, 2021

Cancer immunotherapy has made tremendous clinical progress in advanced-stage malignancies. However, patients with various tumors exhibit a low response rate to because of powerful immunosuppressive tumor microenvironment (TME) and insufficient immunogenicity tumors. Photodynamic therapy (PDT) can not only directly kill cells, but also elicit immunogenic cell death (ICD), providing antitumor immunity. Unfortunately, limitations from the inherent nature complex TME significantly reduce efficiency PDT. Recently, smart nanomedicine-based strategies could subtly modulate pharmacokinetics therapeutic compounds optimize both PDT immunotherapy, resulting an improved effect. Here, emerging nanomedicines for PDT-driven cancer are reviewed, including hypoxia-reversed nanomedicines, nanosized metal-organic frameworks, subcellular targeted nanoparticles (NPs). Moreover, we highlight synergistic nanotherapeutics used amplify immune responses combined against Lastly, challenges future expectations field discussed.

Язык: Английский

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Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

Frontiers in Chemistry, Год журнала: 2021, Номер 9

Опубликована: Авг. 2, 2021

Photodynamic therapy (PDT) has been used as an anti-tumor treatment method for a long time and photosensitizers (PS) can be in various types of tumors. Originally, light is effective tool that the diseases ages. The effects combination specific dyes with illumination was demonstrated at beginning 20th century novel PDT approaches have developed ever since. Main strategies current studies are to reduce off-target improve pharmacokinetic properties. Given high interest vast literature about topic, approval first drug/device by FDA should come no surprise. consists two stages treatment, combining energy PS order destruct tumor cells after activation light. In general, fewer side toxicity than chemotherapy and/or radiotherapy. addition purpose several PSs diagnostic purposes Such called photodynamic diagnosis (PDD). this Review, we provide general overview clinical applications cancer, including therapeutic approaches. Assessment efficacy clinic will discussed, since identifying predictors determine response crucial. addition, examples tumors discussed. Furthermore, other modalities such chemotherapy, radiotherapy, surgery immunotherapy emphasized, seem promising terms enhancing effectiveness against tumor. treatments may yield better results single treatments. Moreover, utilization lower doses setting cause less therapy. A understanding well optimization complex multimodal expand PDT.

Язык: Английский

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Tailoring Materials for Modulation of Macrophage Fate

Advanced Materials, Год журнала: 2021, Номер 33(12)

Опубликована: Фев. 9, 2021

Human immune system acts as a pivotal role in the tissue homeostasis and disease progression. Immunomodulatory biomaterials that can manipulate innate immunity adaptive hold great promise for broad range of prophylactic therapeutic purposes. This review is focused on design strategies principles immunomodulatory from standpoint materials science to regulate macrophage fate, such activation, polarization, adhesion, migration, proliferation, secretion. It offers comprehensive survey discussion tunability material designs regarding physical, chemical, biological, dynamic cues modulating response. The tailorable encompasses surface properties, topography, mechanics, composition, dynamics. representative immunoengineering applications selected herein demonstrate how macrophage-immunomodulating are being exploited cancer immunotherapy, infection regeneration, inflammation resolution, vaccination. A perspective future research directions immunoregulatory also provided.

Язык: Английский

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Molecular and nanoengineering approaches towards activatable cancer immunotherapy

Chemical Society Reviews, Год журнала: 2020, Номер 49(13), С. 4234 - 4253

Опубликована: Янв. 1, 2020

This review summarizes the development of activatable immunotherapeutic nanoagents that activate antitumor immunity only in response to internal or external stimuli, which potentially enhance patient rates while reducing immune-related adverse events during cancer immunotherapy.

Язык: Английский

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Smart Nanovesicle-Mediated Immunogenic Cell Death through Tumor Microenvironment Modulation for Effective Photodynamic Immunotherapy

ACS Nano, Год журнала: 2019, Номер 14(1), С. 620 - 631

Опубликована: Дек. 26, 2019

Combination therapy that could better balance immune activation and suppressive signals holds great potential in cancer immunotherapy. Herein, we serendipitously found the pH-responsive nanovesicles (pRNVs) self-assembled from block copolymer polyethylene glycol-b-cationic polypeptide can not only serve as a nanocarrier but also cause immunogenic cell death (ICD) through preapoptotic exposure of calreticulin. After coencapsulation photosensitizer, 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) an indoleamine 2,3-dioxygenase inhibitor, indoximod (IND), pRNVs/HPPH/IND at single low dose elicited significant antitumor efficacy abscopal effect following laser irradiation B16F10 melanoma tumor model. Treatment attributes to three key factors: (i) singlet oxygen generation by HPPH-mediated photodynamic (PDT); (ii) increased dendritic (DC) recruitment response provocation after ICD induced pRNVs PDT; (iii) microenvironment modulation IND via enhancing P-S6K phosphorylation for CD8+ T development. This study exploited induce host's immunity activation. The "all-in-one" smart allow design multifunctional materials strengthen immunotherapy efficacy.

Язык: Английский

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Microfluidic Sonication To Assemble Exosome Membrane-Coated Nanoparticles for Immune Evasion-Mediated Targeting

Nano Letters, Год журнала: 2019, Номер 19(11), С. 7836 - 7844

Опубликована: Окт. 10, 2019

Using natural membranes to coat nanoparticles (NPs) provides an efficient means reduce the immune clearance of NPs and improve their tumor-specific targeting. However, fabrication these drug-loaded biomimetic NPs, such as exosome membrane (EM)- or cancer cell (CCM)-coated poly(lactic-co-glycolic acid) (PLGA) remains a challenging task owing heterogeneous nature biomembranes labor-intensive procedures. Herein, we report microfluidic sonication approach produce EM-, CCM-, lipid-coated PLGA encapsulated with imaging agents in one-step straightforward manner. Tumor cell-derived EM-coated consisting both endosomal plasma proteins show superior homotypic targeting compared CCM-PLGA similar sizes core-shell structures vitro vivo models. The underlying mechanism is associated significantly reduced uptake EM-PLGA by macrophages peripheral blood monocytes, revealing evasion-mediated homologous tumors. Overall, this work illustrates promise using fabricate for better biocompatibility efficacy.

Язык: Английский

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