Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Small, Год журнала: 2021, Номер 17(12)

Опубликована: Фев. 12, 2021

Abstract Nanotechnology has provided great opportunities for managing neoplastic conditions at various levels, from preventive and diagnostic to therapeutic fields. However, when it comes clinical application, nanoparticles (NPs) have some limitations in terms of biological stability, poor targeting, rapid clearance the body. Therefore, biomimetic approaches, utilizing immune cell membranes, are proposed solve these issues. For example, macrophage or neutrophil membrane coated NPs developed with ability interact tumor tissue suppress cancer progression metastasis. The functionality particles largely depends on surface proteins cells their preserved function during extraction coating process NPs. Proteins outer can render a wide range activities NPs, including prolonged blood circulation, remarkable competency recognizing antigens enhanced better cellular interactions, gradual drug release, reduced toxicity vivo. In this review, nano‐based systems cells‐derived membranous layers, detailed production process, applicability treatment discussed. addition, future perspectives challenges translation also presented.

Язык: Английский

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Engineered Extracellular Vesicles for Cancer Therapy

Advanced Materials, Год журнала: 2021, Номер 33(14)

Опубликована: Фев. 28, 2021

Abstract Extracellular vesicles (EVs) have emerged as a novel cell‐free strategy for the treatment of many diseases including cancer. As result their natural properties to mediate cell‐to‐cell communication and high physiochemical stability biocompatibility, EVs are considered excellent delivery vehicles variety therapeutic agents such nucleic acids proteins, drugs, nanomaterials. Increasing studies shown that can be modified, engineered, or designed improve efficiency, specificity, safety cancer therapy. Herein, comprehensive overview recent advances in strategies methodologies engineering scalable production improved cargo‐loading tumor‐targeting is provided. Additionally, potential applications engineered therapy discussed by presenting prominent examples, opportunities challenges translating into clinical practice evaluated.

Язык: Английский

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Extracellular vesicles: A bright star of nanomedicine

Biomaterials, Год журнала: 2020, Номер 269, С. 120467 - 120467

Опубликована: Ноя. 6, 2020

Язык: Английский

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Bioinspired exosome-like therapeutics and delivery nanoplatforms

Biomaterials, Год журнала: 2020, Номер 242, С. 119925 - 119925

Опубликована: Март 2, 2020

Язык: Английский

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Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis

Molecular Cancer, Год журнала: 2021, Номер 20(1)

Опубликована: Янв. 27, 2021

Abstract Lung cancer is often diagnosed at an advanced stage and has a poor prognosis. Conventional treatments are not effective for metastatic lung therapy. Although some of molecular targets have been identified with favorable response, those cannot be exploited due to the lack suitable drug carriers. cell-derived exosomes (LCCDEs) receive recent interest in its role carcinogenesis, diagnosis, therapy, prognosis biological functions natural ability carry donor cell biomolecules. LCCDEs can promote proliferation metastasis, affect angiogenesis, modulate antitumor immune responses during regulate resistance now considered important component liquid biopsy assessments detecting cancer. Therapeutic deliverable emerging as promising delivery agents specifically tumor high precision medicine because their intercellular communication role, excellent biocompatibility, low immunogenicity, toxicity, long blood circulation ability, biodegradable characteristics, cross various barriers. Several studies currently underway develop novel diagnostic prognostic modalities using LCCDEs, methods exploiting use efficient vehicles. Current status extensive applicability illustrated this review. The data technologies indicate that approach on implies potential application clinical management patients.

Язык: Английский

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Towards microfluidic-based exosome isolation and detection for tumor therapy

Nano Today, Год журнала: 2021, Номер 37, С. 101066 - 101066

Опубликована: Янв. 14, 2021

Язык: Английский

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Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)

Опубликована: Апрель 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Язык: Английский

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Microfluidic Methods for Fabrication and Engineering of Nanoparticle Drug Delivery Systems

ACS Applied Bio Materials, Год журнала: 2019, Номер 3(1), С. 107 - 120

Опубликована: Ноя. 25, 2019

Microfluidic technologies with precise fluid control and rapid microscale mixing have attracted widespread interest in the fabrication engineering of nanomaterials for drug delivery. The drug-loaded prepared by microfluidic methods can exhibit better monodispersity, higher encapsulation efficiency, prolonged blood circulation time as compared to those conventional bench methods. In this review, we summarize recent advances a variety nanomaterials, including organic, inorganic, hybrid nanoparticles, delivery systems. We discuss physicochemical properties these such size, shape, structure, rigidity, surface modification, which affect their therapeutic efficacy some extent. Furthermore, perspective targeted is presented.

Язык: Английский

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Cell primitive-based biomimetic functional materials for enhanced cancer therapy

Chemical Society Reviews, Год журнала: 2020, Номер 50(2), С. 945 - 985

Опубликована: Ноя. 23, 2020

Cell primitive-based functional materials that combine the advantages of natural substances and nanotechnology have emerged as attractive therapeutic agents for cancer therapy. primitives are characterized by distinctive biological functions, such long-term circulation, tumor specific targeting, immune modulation etc. Moreover, synthetic nanomaterials featuring unique physical/chemical properties been widely used effective drug delivery vehicles or anticancer to treat cancer. The combination these two kinds will catalyze generation innovative biomaterials with multiple high biocompatibility negligible immunogenicity precise In this review, we summarize most recent advances in development cell Different primitives, including bacteria, phages, cells, membranes, other bioactive introduced their strategies combining materials, especially nanoparticulate systems, construction function-enhanced also summarized. Furthermore, foreseeable challenges future perspectives included research direction field.

Язык: Английский

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Exosome-based biomimetic nanoparticles targeted to inflamed joints for enhanced treatment of rheumatoid arthritis

Journal of Nanobiotechnology, Год журнала: 2020, Номер 18(1)

Опубликована: Авг. 20, 2020

Glucocorticoids (GCs) show powerful treatment effect on rheumatoid arthritis (RA). However, the clinical application is limited by their nonspecific distribution after systemic administration, serious adverse reactions during long-term administration. To achieve better treatment, reduce side effect, we here established a biomimetic exosome (Exo) encapsulating dexamethasone sodium phosphate (Dex) nanoparticle (Exo/Dex), whose surface was modified with folic acid (FA)-polyethylene glycol (PEG)-cholesterol (Chol) compound to attain FPC-Exo/Dex active targeting drug delivery system.The size of 128.43 ± 16.27 nm, polydispersity index (PDI) 0.36 0.05, and Zeta potential - 22.73 0.91 mV. The encapsulation efficiency (EE) preparation 10.26 0.73%, loading (DLE) 18.81 2.05%. In vitro study showed this system displayed enhanced endocytosis excellent anti-inflammation against RAW264.7 cells suppressing pro-inflammatory cytokines increasing anti-inflammatory cytokine. Further biodistribution fluorescence intensity stronger than other Dex formulations in joints, suggesting its accumulation inflammation sites. vivo experiment could preserve bone cartilage CIA mice significantly inflamed joints. Next safety evaluation demonstrated had no obvious hepatotoxicity exhibited desirable biocompatibility.The present provides promising strategy for using as nanocarrier enhance therapeutic GCs RA.

Язык: Английский

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