Journal of the American Chemical Society,
Год журнала:
2019,
Номер
141(42), С. 16517 - 16538
Опубликована: Сен. 27, 2019
The
past
20
years
have
witnessed
tremendous
advances
in
the
field
of
porous
materials,
including
development
novel
metal–organic
frameworks
(MOFs)
that
show
great
potential
for
practical
applications
aimed
at
addressing
global
environmental
and
industrial
challenges.
A
critical
tool
enabling
this
progress
has
been
reticular
chemistry,
through
which
researchers
can
design
materials
exhibit
highly
regular
(i.e.,
edge-transitive)
topologies,
based
on
assembly
geometrically
matched
building
blocks
into
specific
nets.
However,
innovation
sometimes
demands
steer
away
from
default
topologies
to
instead
pursue
unusual
geometries.
In
Perspective,
we
cover
aspect
introduce
concept
geometry
mismatch,
seemingly
incompatible
are
combined
generate
non-default
structures.
We
describe
diverse
MOF
assemblies
built
mismatch
generated
by
use
ligand
bend
angles,
twisted
functional
groups,
zigzag
ligands
other
elements,
focusing
carboxylate-based
MOFs
with
common
inorganic
clusters.
aim
provide
a
fresh
perspective
rational
help
readers
understand
countless
options
now
available
achieve
greater
structural
complexity
MOFs.
Chemical Reviews,
Год журнала:
2021,
Номер
121(8), С. 4999 - 5041
Опубликована: Март 31, 2021
Manipulation
and
navigation
of
micro
nanoswimmers
in
different
fluid
environments
can
be
achieved
by
chemicals,
external
fields,
or
even
motile
cells.
Many
researchers
have
selected
magnetic
fields
as
the
active
actuation
source
based
on
advantageous
features
this
strategy
such
remote
spatiotemporal
control,
fuel-free,
high
degree
reconfigurability,
programmability,
recyclability,
versatility.
This
review
introduces
fundamental
concepts
advantages
micro/nanorobots
(termed
here
"MagRobots")
well
basic
knowledge
materials,
setups
for
manipulation,
field
configurations,
symmetry-breaking
strategies
effective
movement.
These
are
discussed
to
describe
interactions
between
fields.
Actuation
mechanisms
flagella-inspired
MagRobots
(i.e.,
corkscrew-like
motion
traveling-wave
locomotion/ciliary
stroke
motion)
surface
walkers
surface-assisted
motion),
applications
other
propulsion
approaches,
stimulation
beyond
provided
followed
fabrication
techniques
(quasi-)spherical,
helical,
flexible,
wire-like,
biohybrid
MagRobots.
Applications
targeted
drug/gene
delivery,
cell
minimally
invasive
surgery,
biopsy,
biofilm
disruption/eradication,
imaging-guided
delivery/therapy/surgery,
pollution
removal
environmental
remediation,
(bio)sensing
also
reviewed.
Finally,
current
challenges
future
perspectives
development
magnetically
powered
miniaturized
motors
discussed.
Acta Pharmaceutica Sinica B,
Год журнала:
2021,
Номер
11(8), С. 2362 - 2395
Опубликована: Март 14, 2021
Metal-organic
frameworks
(MOFs),
comprised
of
organic
ligands
and
metal
ions/metal
clusters
via
coordinative
bonds
are
highly
porous,
crystalline
materials.
Their
tunable
porosity,
chemical
composition,
size
shape,
easy
surface
functionalization
make
this
large
family
more
popular
for
drug
delivery.
There
is
a
growing
interest
over
the
last
decades
in
design
engineered
MOFs
with
controlled
sizes
variety
biomedical
applications.
This
article
presents
an
overall
review
perspectives
MOFs-based
delivery
systems
(DDSs),
starting
classification
adapted
DDSs
based
on
types
constituting
metals
ligands.
Then,
synthesis
characterization
developed,
followed
by
loading
strategies,
applications,
biopharmaceutics
quality
control.
Importantly,
representative
applications
detailed
from
point
view
pharmaceutics,
diseases
therapy
advanced
DDSs.
In
particular,
control
summarized
critical
issues
to
be
addressed.
Finally,
challenges
development
discussed,
such
as
biostability,
biosafety,
nomenclature.
Advances
in
medical
robots
promise
to
improve
modern
medicine
and
the
quality
of
life.
Miniaturization
these
robotic
platforms
has
led
numerous
applications
that
leverages
precision
medicine.
In
this
review,
current
trends
micro
nanorobotics
for
therapy,
surgery,
diagnosis,
imaging
are
discussed.
The
use
nanorobots
still
faces
technical,
regulatory,
market
challenges
their
widespread
clinical
settings.
Nevertheless,
recent
translations
from
proof
concept
vivo
studies
demonstrate
potential
toward
Chemical Reviews,
Год журнала:
2021,
Номер
122(5), С. 5365 - 5403
Опубликована: Фев. 1, 2021
Over
the
past
15
years,
field
of
microrobotics
has
exploded
with
many
research
groups
from
around
globe
contributing
to
numerous
innovations
that
have
led
exciting
new
capabilities
and
important
applications,
ranging
in
vivo
drug
delivery,
intracellular
biosensing,
environmental
remediation,
nanoscale
fabrication.
Smart
responsive
materials
had
a
profound
impact
on
imparted
small-scale
robots
functionalities
distinct
capabilities.
We
identified
four
large
categories
where
majority
future
efforts
must
be
allocated
push
frontiers
microrobots
smart
can
major
such
advances.
These
areas
are
propulsion
biocompatibility
microrobots,
cooperation
between
individual
units
human
operators,
finally,
intelligence
microrobots.
In
this
Review,
we
look
critically
at
latest
developments
these
discuss
how
contribute
progress
will
set
stage
for
next
generation
intelligent
programmable
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(7), С. 4541 - 4563
Опубликована: Янв. 1, 2021
Different
chemical,
physical,
and
biomarker
triggers
to
unlock
the
metal–organic
framework
nanoparticles
release
drugs
loaded
in
particles
will
be
addressed.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Янв. 4, 2021
Four-dimensional
(4D)
printing
of
shape
memory
polymer
(SMP)
imparts
time
responsive
properties
to
3D
structures.
Here,
we
explore
4D
a
SMP
in
the
submicron
length
scale,
extending
its
applications
nanophononics.
We
report
new
photoresist
based
on
Vero
Clear
achieving
print
features
at
resolution
~300
nm
half
pitch
using
two-photon
polymerization
lithography
(TPL).
Prints
consisting
grids
with
size-tunable
multi-colours
enabled
study
effects
achieve
large
visual
shifts
through
nanoscale
structure
deformation.
As
nanostructures
are
flattened,
colours
and
printed
information
become
invisible.
Remarkably,
effect
recovers
original
surface
morphology
along
structural
colour
within
seconds
heating
above
glass
transition
temperature.
The
high-resolution
excellent
reversibility
both
microtopography
optical
promises
platform
for
temperature-sensitive
labels,
hiding
anti-counterfeiting,
tunable
photonic
devices.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Сен. 10, 2020
Abstract
Natural
musculoskeletal
systems
have
been
widely
recognized
as
an
advanced
robotic
model
for
designing
robust
yet
flexible
microbots.
However,
the
development
of
artificial
at
micro-nanoscale
currently
remains
a
big
challenge,
since
it
requires
precise
assembly
two
or
more
materials
distinct
properties
into
complex
3D
micro/nanostructures.
In
this
study,
we
report
femtosecond
laser
programmed
prototyping
microbots,
using
relatively
stiff
SU-8
skeleton
and
pH-responsive
protein
(bovine
serum
albumin,
BSA)
smart
muscle.
To
realize
programmable
integration
configuration,
successive
on-chip
two-photon
polymerization
(TPP)
strategy
that
enables
structuring
photosensitive
sequentially
within
predesigned
configuration
was
proposed.
As
proof-of-concept,
demonstrate
spider
microbot
micro-gripper
controllable
grabbing
releasing.
Our
provides
universal
protocol
directly
printing
microbots
composed
multiple
materials.
